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| 1 | Digitally reinforced hematoxylin-eosin polarization technique in diagnosis of rectal amyloidosis显示文摘AIM:To investigate the efficacy of the digitally reinforced hematoxylin-eosin polarization(DRHEP)technique for detection of amyloidosis in rectal biopsies.METHODS:One hundred hematoxylin-eosin(HE)stained rectal biopsies with Congo-red(CR)-positive amyloid depositions and 50 control cases with CRnegative amyloid-mimicking areas were scanned blinded to the CR results for amyloid depositions under both bright and polarized light,and digitally photographed using the DRHEP technique,to accentuate the faint birefringence observed in HE slides under polarization.The results of DRHEP and HE evaluation were statistically correlated with CR polarization results with respect to presence and localization of amyloid deposits as well as amyloid types.RESULTS:Amyloid deposits showed yellowish-green birefringence by DRHEP,which allowed identification of amyloidosis in 41 HE-unsuspected cases(P=0.016),31 of which only had vascular deposits.True positivity was higher,and false negativity and positivity were lower by DRHEP,compared to evaluation by HE(69%,31%,and 0.8%vs 33%,67%,and 33%,respectively;P<0.0001).The sensitivity,specificity,accuracy,and positive and negative predictive values for DRHEP were69%,98%,78.6%,98.5%,and 61.25%,respectively.Reasons for DRHEP false negativity were presence of extensive background birefringence in 12 cases,absence of CR birefringent vessel in 3 cases,and missing of the tiny deposits in 9 cases,which could be improved by experience,especially in the latter case.No correlation was found between age,gender,sites of deposits,or amyloid types.CONCLUSION:The DRHEP technique improves diagnostic accuracy when used as an adjunct or a prior step to CR staining,especially for cases with limited tissues for further analysis. | Basak Doganavsargil Gulruh Emiroglu Buberal Huseyin Toz Banu Sarsik Burcin Pehlivanoglu Murat Sezak Sait Sen | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 2 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 3 | Mortality and cardiovascular events in online haemodiafiltration (OL-HDF) compared with high-flux dialysis:results from the Turkish OL-HDF Study显示文摘 | Ok E Asci G Toz H | 2013 | Nephrol Dial Transplant2013，28，1： | 1 |
| 4 | Photogrammetry and geographic information systems for quick assessment, documentation and analysis of earthquakes 显示文摘 | Altan O Toz G Kulur S | 2001 | Journal of Photogrammetry & Remote Sensing2001，55，56： | 1 |
| 5 | Tuberculosis in renal transplant recipients on various immunosuppressive regimens显示文摘 | ATASEVER A BACAKOGLU F TOZ H | 2005 | Nephrol Dial Transplant2005，20，4： | 1 |
| 6 | Comparison of tacrolimus and cyclosporin in renal transplantation by the protocol biopsies显示文摘 | Toz H Sen S Sezis M Duman S Ozkahya M Ozbek S | 2004 | Transplant Proc2004，36，1： | 1 |
| 7 | Tacrolimus-vs cyclosporinmicroemulsion-based treatment in renal transplantation:comparison with third month protocol biopsies显示文摘 | Toz H Duman S Sen S | 2001 | J Am SocNephrol2001，12，5： | 1 |
| 8 | Photogrammetry and geographic information systems for quick assessment, documentation and analysis of earthquakes显示文摘 | Altan O Toz G Kulur S | 2001 | ISPRS Journal of Photogrammetry & Remote Sensing2001，5，5： | 1 |
| 9 | Effect of fluid management guided by bioimpedance spectroscopy on cardiovascular parameters in hemodialysis patients:a randomized controlled trial显示文摘 | Hur E Usta M Toz H | 2013 | Am J Kidney Dis2013，61，6： | 1 |
| 10 | Risk factors and consequences of post- transplant diabetes mellitus 显示文摘 | Demirci MS Toz H Yilmaz F | 2010 | Clin Transplant2010，24，5： | 1 |
| 11 | Mortality and cardiovascular events in online haemodiafiltration(OL- HDF) compared with high- flux dialysis:results from the Turkish OL-HDF Study显示文摘 | Ercan Ok Gulay Asci Huseyin Toz | 2013 | Nephrol Dial Transplant2013，28，： | 1 |
| 12 | Mortality and cardiovascular e-vents in online hemodiafiltration (OL-HDF) compared withhigh-flux dialysis: results from the Turkish OL-HDF Study显示文摘 | Ok E Asci G Toz H | 2013 | Nephrol Dial Transplant?2013，28，1： | 1 |
| 13 | Dynamics simulation toolbox for industrial robot manipulators显示文摘 | Toz M Kucuk S | 2010 | Computer Applications in Engineering Education2010，18，2： | 1 |
| 14 | Dexterous workspace optimization of an asymmetric six degree of freedom Stewaart-Gough platform type manipulator显示文摘 | Toz M Kucuk S | 2013 | Robotics and Autonomous Systems2013，61，12： | 1 |
| 15 | Impact of volume control on left ventricular hypertrophy in dialysis patients显示文摘 | OZKAHYA M TOZ H QZERKAN F | 2002 | J Nephrol2002，15，： | 1 |
| 16 | Comparison of tacrolimus and cyclosporin in renal transplantation by the protocol biopsies显示文摘 | Toz H Sen S Sezis M | 2004 | Transplant Proc2004，36，1： | 1 |
| 17 | Clinicopathological features of hepetitis C virus infection in dialysis and renal transplantation显示文摘 | Toz H Ok E Yilmaz F | 2002 | J Nephrol2002，15，3： | 1 |
| 18 | Mortality and cardiovascular events in online haemodiafiltration(OL-HDF)compared with high-flux dialysis:results from the Turkish OL-HDF Study显示文摘 | Ok E Asci G Toz H | | 0，，： | 1 |
| 19 | Mortality and cardiovascu-lar events in online haemod i af i11rat ion (0L-HDF) com-pared with high-flux dialysis: results from the Turk-ish OL-HDF Study显示文摘 | 0k E Asci G Toz H | 2013 | Nephrol Dial Transplant2013，28，1： | 1 |
| 20 | Biochemical parameters, renal function, and outcome of pregnancy in kidn-ey transplant recipient显示文摘 | Celik G Toz H Ertilav M | 2011 | Transplant Proc2011，43，7： | 1 |
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