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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure显示文摘BACKGROUND Acute cardiorenal syndrome type 1(CRS-1)is defined by a rapid cardiac dysfunction leading to acute kidney injury(AKI).Neutrophil gelatinaseassociated lipocalin(NGAL)is expressed on the surface of human neutrophils and epithelial cells,such as renal tubule cells,and its serum(sNGAL)and urinary have been used to predict AKI in different clinical settings.AIM To characterize CRS-1 in a cohort of patients with acute heart diseases,evaluating the potentiality of sNGAL as an early marker of CRS-1.METHODS We performed a retrospective cohort,multi-centre study.From January 2010 to December 2011,we recruited 202 adult patients admitted to the coronary intensive care unit(CICU)with a diagnosis of acute heart failure or acute coronary syndrome.We monitored the renal function to evaluate CRS-1 development and measured sNGAL levels within 24 h and after 72 h of CICU admission.RESULTS Overall,enrolled patients were hemodynamically stable with a mean arterial pressure of 92(82-107)mmHg,55/202(27.2%)of the patients developed CRS-1,but none of them required dialysis.Neither the NGAL delta value(AUC 0.40,95%CI:0.25-0.55)nor the NGAL peak(AUC 0.45,95%CI:0.36-0.54)or NGAL cutoff(≥140 ng/mL)values were statistically significant between the two groups(CRS-1 vs no-CRS1 patients).The area under the ROC curve for the prediction of CRS-1 was 0.40(95%CI:0.25-0.55)for the delta NGAL value and 0.45(95%CI:0.36-0.54)for the NGAL peak value.Finally,in multivariate analysis,the risk of developing CRS-1 was correlated with age>60 years,urea nitrogen at admission and 24 h-urine output(AUC 0.83,SE=60.5%SP=93%),while sNGAL was not significantly correlated.CONCLUSION In our population,sNGAL does not predict CRS-1,probably as a consequence of the mild renal injury and the low severity of heart disease.So,these data might suggest that patient selection should be taken into account when considering the utility of NGAL measurement as a biomarker of kidney damage. | Fiorenza Ferrari Elisa Scalzotto Pasquale Esposito Sara Samoni Flavio Mistrorigo Lilia Maria Rizo Topete Massimo De Cal Grazia Maria Virzì Valentina Corradi Rossella Torregrossa Roberto Valle Stefania Bianzina Nadia Aspromonte Matteo Floris Alessandro Fontanelli Alessandra Brendolan Claudio Ronco | 2020 | World Journal of Clinical Cases2020，8，9： | 3 |
| 3 | Galectin-3 ishighly expressed in nonencapsulatedpapillary thyroidcarcinoma but weakly expressed in encapsulated type; com-parison with Hector Battifora mesothelial cell 1 immunoreac-tivity显示文摘 | Torregrossa L Faviana P Camacci T | 2007 | Hum Pathol2007，38，： | 1 |
| 4 | Visceral Adiposity Index ( VAI )Is Predictive of an Altered Adipokine Profile in Patients with Type 2 Diabetes显示文摘 | Amato MC Pizzolanti G Torregrossa V Misiano G Milano S | 2014 | PLoS ONE2014，9，91： | 1 |
| 5 | CXCR4 expression correlates with the degree of tumor infiltration and BRAF status in papillary thyroid carcinomas显示文摘 | Torregrossa L Giann{ni R Borrelli N | 2012 | Mod Patho2012，25，1： | 1 |
| 6 | Turnover of oxygen and hydrogen isotopes in the body water,CO2,hair,and enamel of a small mammal显示文摘 | Podlesak D W Torregrossa A Ehleringer J R | | 0，，01： | 1 |
| 7 | Performances of a granular sequencing batch reactor (GSBR) 显示文摘 | Torregrossa M DiBella G Viviani G | 2007 | Water Science and Technology2007，55，89： | 1 |
| 8 | ABO-incompatible heart transplantation: crossing the immunological barrier 显示文摘 | Gambino A Torregrossa G Cozzi E | 2008 | J Car diovascMed2008，9，8： | 1 |
| 9 | Correlation betweenthe BRAF V600E mutation and tumor invasiveness in papillarythyroid carcinomas smaller than 20 millimeters:analysis of 1060cases显示文摘 | Basolo F Torregrossa L Giannini R | 2010 | J Clin Endocrinol Metab2010，95，9： | 1 |
| 10 | Genes involved in TGF betal-driven epithelial- mesenchymal transition of renal epithelial cells are topologicaUy related in the human interactome map显示文摘 | Campanaro S Picelli S Torregrossa R | 2007 | BMC Genomics2007，383，8： | 1 |
| 11 | TGFbetal induces epithelial-mesenchymal transition,but not myofibroblast transdifferentiation of human kidney tubular epithelial cells in primary culture显示文摘 | Forino M Torregrossa R Ceol M | 2006 | Int J Exp Pathol2006，87，3： | 1 |
| 12 | Bidirectional modulation of in- fraiimbic dopamine D1 and D2 receptor activity regulates flexible re- ward seeking显示文摘 | Barker JM Torregrossa MM Taylor JR | 2013 | Front Neurosci2013，7，2： | 1 |
| 13 | Identification of GDNF gene sequence variations in patients with medullary sponge kidney disease显示文摘 | Torregrossa R Anglani F Fabris A | 2010 | Clin J Am Soc Nephrol2010，5，12： | 1 |
| 14 | Preference for sucralose predicts behavioral responses to sweet and bittersweet tastants 显示文摘 | Loney G C Torregrossa A M Carballo C | 2012 | Chemical Senses2012，5，37： | 1 |
| 15 | CXC Chemokine re- ceptor 4 immunodetection in the follicular variant of papillary thy- roid carcinoma: comparison to galectin-3 and hector battifora mes- othelial celH 显示文摘 | Torregrossa L Faviana P Filice ME | 2010 | Thyroid2010，20，5： | 1 |
| 16 | Galectin-3 is highly expressed in noencapsulated papillary thyroid carcinoma but weakly expressed in encapsulated type;comparison with Hector Battifora mesothelial cell 1 immunoroactivity显示文摘 | Torregrossa L Faviana P Camacci T | 2007 | Hum Pathol2007，38，10： | 1 |
| 17 | Cardiorenal SyndromeType 1 May Be Immunologically Mediated: A Pilot Evaluation ofMonocyte Apoptosis显示文摘 | Virzì GM Torregrossa R Cruz DN | 2012 | Cardiorenal Med2012，2，1： | 1 |
| 18 | A case of metastatic haemangiopericytoma to the thyroid gland: case report and literature review显示文摘 | Proietti A Sartori C Torregrossa L | 2012 | Oncol Lett2012，3，6： | 1 |
| 19 | Performance of a granular sequencing batcfi reactor (GSBR)显示文摘 | Torregrossa M Dibella G Viviani G | 2007 | Water Science and Technology2007，55，89： | 1 |
| 20 | Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats显示文摘 | Torregrossa MM Jutkiewicz EM Mosberg HI | | 0，，01： | 1 |
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