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| 1 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 2 | Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure显示文摘AIM To analyze the expression and function of the notchsignaling target gene Hes1 in a rhesus rotavirusinduced mouse biliary atresia model. METHODS The morphologies of biliary epithelial cells in biliary atresia patients and in a mouse model were examined by immunohistochemical staining. Then, the differential expression of Notch signaling pathway-related molecules was investigated. Further, the effects of the si RNAmediated inhibition of Hes1 expression were examined using a biliary epithelial cell 3 D culture system.RESULTS Both immature(Ep CAM+) and mature(CK19+) biliary epithelial cells were detected in the livers of biliary atresia patients without a ductile structure and in the mouse model with a distorted bile duct structure. The hepatic expression of transcripts for most Notch signaling molecules were significantly reduced on day 7 but recovered to normal levels by day 14, except for the target molecule Hes1, which still exhibited lower m RNA and protein levels. Expression of the Hes1 transcriptional co-regulator, RBP-Jκ was also reduced. A 3 D gel culture system promoted the maturation of immature biliary epithelial cells, with increased expression of CK19+ cells and the formation of a duct-like structure. The administration of Hes1 si RNA blocked this process. As a result, the cells remained in an immature state, and no duct-like structure was observed.CONCLUSION Our data indicated that Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia. | Rui-Zhong Zhang Xin-Hao Zeng Ze-Feng Lin Ming-Fu Yan-Lu Tong Vincent CH Lui Paul KH Tam Jonathan R Lamb Hui-Min Xia Yan Chen | 2018 | World Journal of Gastroenterology2018，24，29： | 5 |
| 3 | A Coupled Variable Coefficient Modified KdV Equation Arising from a Two-Layer Fluid System显示文摘A quite general coupled variable coefficient modified KdV (VCmKdV) equation in a two-layer fluid systemis derived by means of the reductive perturbation method.Making use of the CK's direct method,some similarityreductions of the coupled VCmKdV equation are obtained and their corresponding group explanations are discussed.Some exact solutions of the coupled equations are also presented. | GAO Yuan~1 and TANG Xiao-Yan~(1,2)~1 Department of Physics,Shanghai Jiao Tong University,Shanghai 200240,China~2 Institut Für Theoretische Physik IV,Fakultt für Physik und Astronomie,Ruhr-Universitt Bochum,D-44870 Bochum,Germany | 2007 | Communications in Theoretical Physics2007，，12： | 3 |
| 4 | P53 based blood test for P53 PIN3 and risk for sporadic ovarian cancer显示文摘 | Runnenbaum IB Tong XW Konig R | 1995 | Lancet1995，354，： | 2 |
| 5 | A Linguistic Approach to Decision Making with Fuzzy Sets显示文摘 | Bonissone P P | 1980 | IEEE Transactions on Systems Man and Cybernetics1980，10，： | 1 |
| 6 | Heuristic approaches to vehicle routing with backhauls and time windows显示文摘 | Sam R T Jean Y P Tong S | 1996 | Computers and Operations Research1996，23，11： | 1 |
| 7 | Effect of valsartan and captopril in rabbit carotid injury:possible involvement of bradykinin in the anti-proliferative action of the reninangiotensin blockade显示文摘 | Tong C F Ying W Y Hua R Y | 2001 | JRAAS2001，2，1： | 1 |
| 8 | Beta-- amyloid peptide at sublethal concentrations downregulates brain--derived neurotrophic factor functions in cultured cortical neurons显示文摘 | Tong L Balazs R Thornton PL | 2004 | Neurosci2004，24，30： | 1 |
| 9 | Small rat islets are superior to large islets in in vitro function and in transplantation outcomes 显示文摘 | MacGregor R R Williams S J Tong P Y | 2006 | Am J Physiol Endocrinol Metab2006，290，5： | 1 |
| 10 | Vascular normal- ization by vascular endothelial growth faetor receptor 2 block- ade induces a pressure gradient aeross the vasculature and im- proves drug penetration in tumors显示文摘 | Tong R T Boucher Y Kozin S V | 2004 | Cancer Res2004，64，11： | 1 |
| 11 | Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase显示文摘 | Tong L Prieto GA Kramár EA | | 0，，49： | 1 |
| 12 | Critics of Admirer Sees Dumb Racist显示文摘 | Tong Benjamin R | 1977 | The San Francisco Journal1977，，11： | 1 |
| 13 | Ecosystem service values and restoration in the urban Sanyang wetland of Wenzhou,China显示文摘 | TONG Chunfu FEAGIN R A LU J ianjian | 2007 | Ecological Engineering2007，29，6： | 1 |
| 14 | An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast 显示文摘 | Bauman R A Ling G Tong L | 2009 | J Neurotraurna2009，26，6： | 1 |
| 15 | Free Abrasive Wear Behavior of UHMWPE Composites Filled with Wollastonite Fibers显示文摘 | Tong Jin Ma Yunhai Amell R D | 2006 | Composites Part A: Applied Science and Manufaturing2006，37，1： | 1 |
| 16 | Solution structure of a TBP-TAFII230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP显示文摘 | Liu D Ishima R Tong KI | 1998 | Cell1998，94，5： | 1 |
| 17 | Genotyping of B and non-B subtypes of human immunodeficiency virus type 1显示文摘 | Tong CY Mullen J Kulasegaram R | 2005 | J Clin Microbiol2005，43，9： | 1 |
| 18 | Large vestibular aqueduct syndrome:a genetic disease?显示文摘 | TONG K A HARNSBERGER H R DAHLEN R T | 1997 | AJR Am J Roentgenol1997，168，4： | 1 |
| 19 | Bioengineering and management for efficient phosphorus utilization in crops and pastures显示文摘 | Tian J Wang X R Tong Y P et ol | 2012 | Current Opinion in Biotechnology2012，23，6： | 1 |
| 20 | A framework far learning predictive struc- tures from multiple tasks and unlabeled data 显示文摘 | Ando R K Zhang Tong | 2005 | Journal of Ma- chine Learning Research2005，6，6： | 1 |
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