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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 3 | Temperature variations inside Chinese solar greenhouses with external climatic conditions and enclosure materials显示文摘Chinese solar greenhouses enable the extension of the crop growing season in the cold climate in Northern China with little or no additional heating.The temporal variations of the air temperatures inside solar greenhouses located at three cities in North,Northeast and Northwest China were predicted by CFD simulations of the greenhouse systems using typical meteorological data.The predicted temperatures based on the meteorological data in Shenyang are quite similar to the measured temperatures.The results also show that the external air temperatures and solar radiation fluxes play more important roles for the inside temperatures as indicated by the highest inner temperature in the morning on Feb.18 and from 10:00 to 14:00 on Feb.19 in Beijing and by the predicted temperatures inside the greenhouse being higher in Lanzhou than those in Shenyang and Beijing during most of the day.The average daily temperature inside the greenhouse in Lanzhou was nearly 3.5℃higher than that in Shenyang.Predicted air temperatures for various wall designs show that for single walls,the daily average interior temperatures in the aerated concrete wall greenhouse were higher than those in the brick wall and reinforced concrete wall greenhouses.However,the air temperature fluctuations were lower in the reinforced concrete wall greenhouse due to greater thermal storage capacity.The results also show that the temperatures in the layered wall greenhouses are quite similar,which coincides with the experimental results。 | Tong Guohong David M Christopher Li Tianlai Wang Tieliang | 2008 | International Journal of Agricultural and Biological Engineering2008，1，2： | 10 |
| 4 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 5 | Nonlinear Bend Stiffener Analysis Using A Simple Formulation and Finite Element Method显示文摘Flexible marine risers are commonly used in deepwater floating systems.Bend stiffeners are designed to protect flexible risers against excessive bending at the connection with the hull.The structure is usually analyzed as a cantilever beam subjected to an inclined point load.As deflections are large and the bend stiffener material exhibits nonlinear stress-strain characteristics,geometric and material nonlinearities are important considerations.A new approach has been developed to solve this nonlinear problem.Its main advantage is its simplicity;in fact the present method can be easily implemented on a spreadsheet.Finite element analysis using ABAQUS is performed to validate the method.Solid elements are used for the bend stiffener and flexible pipe.To simulate the near inextensibility of flexible risers,a simple and original idea of using truss elements is proposed.Through a set of validation studies,the present method is found to be in a good agreement with the finite element analysis.Further,parametric studies are performed by using both methods to identify the key parameters and phenomena that are most critical in design.The most important finding is that the common practice of neglecting the internal steel sleeve in the bend stiffener analysis is non-conservative and therefore needs to be reassessed. | TONG Dong Jin LOW Ying Min SHEEHAN John M | 2011 | China Ocean Engineering2011，25，4： | 6 |
| 6 | Effects of Preheating Temperature, Moisture and Sodium Metabisulfite Content on Property of Maize Flour Dough显示文摘Processing temperature, maze flour particle size, and level of water and sodium metabisulfite were varied during the preparation of maize noodles. Preheated to 90—95 ℃ a mixture of maize flour or meal, water(43%—45% moisture) and salt enabled the preparation of noodles using a pasta extruder. Maize flour with smaller particle size yielded better noodles than did maize meal. The addition of sodium metabisulfite enabled the production of noodles at lower processing temperatures; however, cooking losses increased. Processing maize flour with higher water absorption yielded noodles that required longer cooking time but with decreased losses. The functionalities of starch and protein in raw ingredients and in products were determined. Starch gelatinized and retorgraded during processing maize noodles, as indicated by changes in pasting viscosity curves. Maize proteins contributed to the increased viscosity of dough above 40 ℃. The increased integrity of cooked maize noodles, however, corresponded to the increased amounts of gelatinized and retrograded starch. | TONG Yi 1, Waniska Ralph D. 2 and LI Wei 1** (1. College of Life Science, Jilin University, Changchun, 130023 2. Cereal Quality Laboratory, Department of Soil & Crop Sciences, Texas A & M University, College Station, Texas, 77843 24474) | 2000 | Chemical Research in Chinese Universities2000，16，3： | 2 |
| 7 | Solution structure of the epithelial cadherin domain responsible for selective cell adhesion显示文摘 | Overduin M Harvey TS Bagby S Tong KI Yau P Takeichi M Ikura M | | 0，，： | 2 |
| 8 | Surface plasmon enhanced infrared photodetection显示文摘Infrared photodetectors have been used extensively in biomedicine, surveillance, communication and astronomy. However, state of the art technology based on III-V and II-VI compounds still lacks excellent performance for high-temperature operation. Surface plasmon polaritons (SPPs) have demonstrated their capability in improving the light detection from visible to infrared wave range due to their light confinement in subwavelength scale. Advanced fabrication techniques such as electron-beam lithography (EBL) and focused ion-beam (FIB), and commercially available numerical design tool like Finite-Difference Time-Domain (FDTD) have enabled rapid development of surface plasmon (SP) enhanced photodetectors. In this review article, the basic mechanisms behind the SP-enhanced photodetection, the different type of plasmonic nanostructures utilized for enhancement, and the reported SP-enhanced infrared photodetectors will be discussed. | Jinchao Tong Fei Suo Junhuizhi Ma Landobasa Y. M Tobing Li Qian Dao Hua Zhang | 2019 | Opto-Electronic Advances2019，2，1： | 2 |
| 9 | A Linguistic Approach to Decision Making with Fuzzy Sets显示文摘 | Bonissone P P | 1980 | IEEE Transactions on Systems Man and Cybernetics1980，10，： | 1 |
| 10 | Metal-organic molecular architectures with 2,2′-bipyridyl-like and carboxylate ligands显示文摘 | Ye B H Tong M L Chen X M | 2005 | Coord Chem Rev2005，249，： | 1 |
| 11 | Cognitive medium access: constraining interference based on experimental models 显示文摘 | GEIRHOFER S TONG L SADLAR B M | 2008 | IEEE Journal on Selected Areas in Communications2008，26，1： | 1 |
| 12 | Use of allopurinol in showing the propression of renal diseased through its ability to lower serum uric acid level显示文摘 | Sin Y Leung K Tong M | 2006 | Am J Kinduey Dis2006，47，1： | 1 |
| 13 | Huanglian, A Chinese herbal extract, inhibits cell growth by suppressing the expression of cyclin B1 and inhibiting CDC2 kinase activity in human cancer cells显示文摘 | Li XK Motwani M Tong W | 2000 | Mol Pharmacol2000，58，6： | 1 |
| 14 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 15 | Attenuation correction of myocardial SPECT studies using low resolution computed tomography images显示文摘 | Tonge CM Manoharan M Lawson RS | 2005 | Nucl Med Commun2005，26，： | 1 |
| 16 | Preparation of Monodispersed Solid Lipid Microspheres Using a Microchannel Emulsification Technique 显示文摘 | Sugiura S Nakajima M Tong J | 2000 | J Colloid Interface Sci2000，227，7： | 1 |
| 17 | Vascμlar endothelial growth factor is an autocrine growth factor for VEGF receptor-positive human tumors显示文摘 | Rizwan M Jie C Tong Z | 2001 | Blood2001，98，6： | 1 |
| 18 | The Influence of retained austenite in high chromium cast iron on impact-abrasive wear显示文摘 | TONG J M ZHOU Y Z SHEN T Y and DENG H J | 1990 | Wear1990，135，2： | 1 |
| 19 | Outdoor activity and myo- pia in Singapore teenage children 显示文摘 | DIRANI M TONG L GAZZARD G | 2009 | Br J Ophthalmol2009，93，8： | 1 |
| 20 | Characterization of a Nano- crystalline NiTiHf High Temperature Shape Memory Alloy Thin Film显示文摘 | Tong Y X Liu Y Miao J M | 2005 | Scripta Materialia2005，52，： | 1 |
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