|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Treatment of intertrochanteric fractures in geriatric patients with a modified external fixator显示文摘 | Tomak Y Kocaoglu M Piskin A | 2005 | Injury2005，36，5： | 1 |
| 3 | Comparison of autograft,coralline graft,and xenograft in promoting posterior spinal fusion 显示文摘 | Karaismailoglu TN Tomak Y Andae A | 2002 | Aeta Orthop Traumatol Tulx:2002，36，2： | 1 |
| 4 | Treatment of intertrochanteric fractures in geriatric patients with a modified external fixator显示文摘 | Tomak Y Kocaoglu M Piskin A | 2005 | Injury2005，36，5： | 1 |
| 5 | Subungual glomus tumours of the hand:diagnosis and treatment of 14 cases显示文摘 | Tomak Y Akcay I Dabak N | 2003 | Scand J Plast Reconstr Surg Hand Surg2003，，： | 1 |
| 6 | The Self-consistent Calculation of A Spherical QuantumDot:A Quantum Genetic Algorithm Study显示文摘 | A Aahin Mehmet Tomak Mehmet | 2005 | Physica E:Low-dimensional Systems2005，28，3： | 1 |
| 7 | Treatment of intertrochaneric fractures in geriatric patients with a modified external fixator显示文摘 | Tomak Y Kocaoglu M Piskin A | 2005 | Injury2005，36，： | 1 |
| 8 | The management of cubitus varus and valgus using the Ilizarov method显示文摘 | Piskin A Tomak Y Sen C | 2007 | J Bone Joint Surg2007，89，： | 1 |
| 9 | Effect of dexmedetomidine iv on the duration of spinal anesthesia with prilocaine: a doubleblind,prospec- tive study in adult surgical patients显示文摘 | Tekin M Kati I Tomak Y | 2007 | Curent Therapeutic Research2007，68，： | 1 |
| 10 | Treatment of humeral shaft non-unions by the Ilizarov method显示文摘 | Koeao~lu M Eralp 1 Tomak Y | 2001 | Int Orthop2001，25，6： | 1 |
| 11 | The management of cubitus varus and valgus using the Ilizarov method显示文摘 | Piskin A Tomak Y Sen C | 2007 | J Bone Joint Surg[Br]2007，12，： | 1 |
| 12 | Treatment of intertrochanteric fractures in geriatric patients with a modified external fixator显示文摘 | Tomak Y Kocaoglu M Piskin A | | 0，，05： | 1 |
| 13 | Evolution of the management of tentorial dural arteriovenous malformations 显示文摘 | Cloft HJ Kaga A | 2003 | Neuro-surgery2003，52，4： | 1 |
| 14 | Evolution of the management of tentorial dural arteriovenous malformations显示文摘 | Tomak PR CloftHJ KagaA | | 0，，4： | 1 |
| 15 | Treatment of intertrochanteric fractures in geriatric patients with a modified external fixator显示文摘 | Tomak Y Kocaoglu M Piskin A | 2005 | Injury2005，36，5： | 1 |
| 16 | The combined effects of boron and oil heat treatment on the properties of beech and Scots pine wood:part 2:water absorption,compression strength,color changes,and decay resistance显示文摘 | TOMAK E D VIITANEN H YILDIZ U C | 2011 | Journal of Materials Science2011，46，3： | 1 |
| 17 | Treatment of in-tertrochanteric fractures in geriatric patients with a modi-fied external fixator显示文摘 | Tomak Y Kacaoglu M Piskin A | 2005 | Injury2005，36，： | 1 |
| 18 | The management of cubitus varus and valgus using the Ilizarov method显示文摘 | Piskin A Tomak Y Sen C et ai | 2007 | J Bone Joint Surg Br2007，89，12： | 1 |
| 19 | Thermal and mechanical properties of Cu-Au intermetallic alloys显示文摘 | Kart H H Tomak M Cagin T | 2005 | Modell Simul Mater Sci Eng2005，13，5： | 1 |
| 20 | Treatment of intertrochaneric fractures in geriatric patients with a modified external fixator显示文摘 | Tomak Y Kocaoglu M Piskin A | 2005 | Injury2005，36，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员