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| 1 | Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype:Results of a 25-year follow-up study显示文摘IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study.METHODS: Eight hundred and seventy-three IBD patients were enrolled (ulcerative colitis/UC/: 619, m/f: 317/302,mean age at presentation: 38.3 years, average disease duration: 11.2 years; Crohn's disease/CD/: 254, m/f: 125/129,mean age at presentation: 32.5 years, average disease duration: 9.2 years). Intestinal, extraintestinal signs and laboratory tests were monitored regularly. Any alteration suggesting an EIMs was investigated by a specialist.RESULTS: A total of 21.3% of patients with IBD had EIM (UC: 15.0%, CD: 36.6%). Age at presentation did not affect the likelihood of EIM. Prevalence of EIMs was higher in women and in CD, ocular complications and primary sclerosing cholangitis (PSC) were more frequent in UC. In UC there was an increased tendency of EIM in patients with a more extensive disease.Joint complications were more frequent in CD (22.4% VS UC 10.2%, P<0.01). In UC positive family history increased the risk of joint complications (OR:3.63). In CD the frequency of type-1 peripheral arthritis was increased in patients with penetrating disease (P=0.028). PSC was present in 1.6% in UC and 0.8% in CD. Dermatological complications were present in 3.8% in UC and 10.2% in CD, the rate of ocular complications was around 3% in both diseases. Rare complications were glomerulonephritis, autoimmune hemolytic anaemia and celiac disease.CONCLUSION: Prevalence of EIM in Hungarian IBD patients is in concordance with data from Western countries. The high number of EIM supports a role for complex follow-up in these patients.ACKNOWLEDGEMENTDr. Zsuzsanna Erdelyi, Dr. Agnes Horvath, Dr Gabor Mester (Veszprem), Dr. Sandor Meszaros (Ajka), Dr. Csaba Molnar help in data collection and to Gabriella Demenyi for technical assistance. | Laszlo Lakatos Tunde Pandur Gyula David Zsuzsanna Balogh Pal Kuronya Arpad Tollas Peter Laszlo Lakatos | 2003 | World Journal of Gastroenterology2003，9，10： | 25 |
| 2 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hqq00vubxvc6q6bpx.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 3 | Dermatomyositis as an early manifestation and a significant clinical precursor of lung cancer:report of a rare case and review of the current literature显示文摘 | Tsoukalas N Tolla M Kostakls D | 2013 | Int J Clin Exp Med2013，6，2： | 1 |
| 4 | Acute intermittent porphyria显示文摘 | Tollanes G Nielsen EW Brekke OL | 2002 | Tidsskr Nor Laegeforen2002，122，： | 1 |
| 5 | Softening of nanocrystalline metals at very small grain sizes 显示文摘 | Mechanical Prog Mater small-sized size effect Schiotz J Di Tolla F D Jacobsen K W | 1998 | Nature1998，391，： | 1 |
| 6 | Atomic-scale simulations of the mechanical deformation of nanocrystalline metals显示文摘 | SCHIOTZ J VEGGE T TOLLA F D D | | 0，，17： | 1 |
| 7 | Excess risk of adverse pregnancy outcomes in women with porphyria:a population-based cohort study显示文摘 | Tollanes MC Aarsand AK Sandberg S | 2011 | J Inherit Metab Dis2011，34，： | 1 |
| 8 | A hybrid search combing interior point methods and metaheuristics for 0 - 1 programming 显示文摘 | PLATEEAU A TACHAT D TOLLA P | 2002 | International Transactions on Operational Research2002，，9： | 1 |
| 9 | A hybrid searchcomb- ing interior point methods and metaheuristics for 0-1 programming显示文摘 | Plateau A Tachat D Tolla P | 2002 | International Transactions on Operational Research2002，，9： | 1 |
| 10 | Softening of nanocrystalline metals at very small grain size显示文摘 | Di Tolla F D Jacobsen K W | 1998 | Nature1998，391，： | 1 |
| 11 | Softening of nanocrystalline metals at very small grain size显示文摘 | Schiotz J Tolla F D D Jacobsen W | 1998 | Nature1998，391，： | 1 |
| 12 | Softening of nanocrystalline metals at very small grain sizes 显示文摘 | Schiotz J Francesco D Di Tolla Jacobsen Karsten W | 1995 | Nature1995，391，： | 1 |
| 13 | Thoracic paravertebral anesthesia for percutaneous radiofrequency ablation of hepatic tumors显示文摘 | Federico Piccioni Luca Fumagalli Francesco Garbagnati Giuseppe Di Tolla Mazzaferro Vincenzo Martin Langer | 2013 | Journal of Clinical Anesthesia2013，，： | 1 |
| 14 | Atomic-scale simulations of the mechanical deformation of nanocrystalline metals显示文摘 | SCHIOTZ J VEGGE T DI TOLLA F D JACOBSEN K W | 1999 | Phys Rev B1999，60，11： | 1 |
| 15 | Softening of nanocrystalline metals at very small grain size 显示文摘 | SCHφTZ J TOLLA F D D JACOBSEN K W | 1998 | Nature1998，391，6667： | 1 |
| 16 | Atomic-scale simulations of the mechanical deformation of nanocrystalline metals 显示文摘 | Schitz J Vegge T Tolla F D D | 1999 | Phys Rev B1999，60，11： | 1 |
| 17 | Softening of nanocrystalline metals at very small grain sizes显示文摘 | Schiotz J Di Tolla F D Jacobsen K W | 1998 | Nature1998，39，： | 1 |
| 18 | Atomic-scale simulations of the mechanical deformation of nanocrystalline metals显示文摘 | Schitz J Vegge T Tolla F D | 1990 | Physical Review B1990，60，11： | 1 |
| 19 | Softening of nanocrystalline metals at very small grain sizes 显示文摘 | Di Tolla F D Jacobsen K W | 1998 | Nature1998，391，： | 1 |
| 20 | Softening of nanocrystalline metals at very small grain sizes显示文摘 | Schiotz J Francesco D Di Tolla Jacobsen Karsten W | 1998 | Nature1998，391，： | 1 |
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