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| 1 | Effects of ghrelin on interdigestive contractions of the rat gastrointestinal tract显示文摘Ghrelin causes interdigestive contractions of the stom- ach in rats. However, it remains unknown whether ghrelin causes interdigestive contractions in the small intestine. Four strain gauge transducers were implanted on the antrum, duodenum, proximal and distal jejunum. After an overnight fast, gastrointestinal (GI) contrac- tions were recorded in freely moving conscious rats. Spontaneous phase Ⅲ-like contractions were observed at every 13-16 min in rat GI tract. The fasted motor patterns were replaced by the fed motor pattern immediately after food intake. Two minutes after f inishing the spontaneous phase Ⅲ-like contractions in the antrum, acyl ghrelin (0.8, 2.4 and 8.0 μg/kg per min) was con- tinuously infused for 30 min. Three-f ive minutes after the starting ghrelin infusion, augmented phase Ⅲ-like contractions were observed at the antrum, duodenum, and jejunum. Ghrelin infusion (0.8, 2.4 and 8.0 μg/kg per min) signif icantly increased motility index of phase Ⅲ-like contractions at the antrum and jejunum in a dose dependent manner, compared to that of saline in- jection. Thus, it is likely that exogenously administered ghrelin causes phase Ⅲ-like contraction at the antrum, which migrates to the duodenum and jejunum. The possible role of 5-HT, in addition to ghrelin, in mediating intestinal migrating motor complex (MMC), is discussed. | Hiroshi Taniguchi Hajime Ariga Kirk Ludwig Toku Takahashi | 2008 | World Journal of Gastroenterology2008，14，41： | 10 |
| 2 | Anti-Stress Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Colonic Motility in Rats显示文摘 | Sazu Yoshimoto Reji Babygirija Anthony Dobner Kirk Ludwig Toku Takahashi | 2012 | Digestive Diseases and Sciences2012，，5： | 2 |
| 3 | Dailyintake of high dietary fiber slows accelerated colonic transit induced by restrain stress inrats显示文摘 | Toku T Yukiomi N Hiroyuki F et a1 | 2008 | Dig Dis Sci2008，53，5： | 1 |
| 4 | Severe acute interstitial pneumonia and gefitinib 显示文摘 | Inoue A Saijo Y Maemondo M Gomi K Tokue Y Kimura Y | 2003 | Lancet2003，361，9352： | 1 |
| 5 | Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors 显示文摘 | Suzuki K Tokue A Kamiakito T | 2001 | Virchows Arch2001，439，5： | 1 |
| 6 | Astrocytes prevent neu- ronal death induced by reactive oxygen and nitrogen species 显示文摘 | TANAKA J TOKU K ZHANG B | 1999 | Glia1999，28，2： | 1 |
| 7 | Effect of citrate and pyrophosphate on the stability of calcium oxalate dihydrate显示文摘 | Yuzawa M Tozuka K Tokue A | 1998 | Urol Res1998，26，： | 1 |
| 8 | Neurons induce the activation of microglial cells in vitro 显示文摘 | Tanaka J Toku K | 1998 | Exp Neurol1998，154，： | 1 |
| 9 | Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA显示文摘 | Morita T Matsuzaki A Tokue A | 2001 | Int J Cancer2001，92，： | 1 |
| 10 | Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes显示文摘 | Shigeomi Shimizu Toku Kanaseki Noboru Mizushima | 2004 | Nature cell biology2004，6，： | 1 |
| 11 | High-level fluoroquinolone-resistant clinical isolates of Escherichiacoli overproduce multidrug efflux protein AcrA显示文摘 | Mazzariol A Tokue Y Kanegawa TM | 2000 | Antimicob Agents Chemother2000，44，12： | 1 |
| 12 | Comparative in vitro activity of carbapenem antibiotics against respiratory pathogens isolated between 1999 and 2000显示文摘 | Watannabe A Tokue Y Takahashi H | 2001 | J Infect Chemother2001，7，4： | 1 |
| 13 | Anchoring system-as- sisted coil tract embolization: a new technique for manage- ment of arterial bleeding associated with percutaneous nephr- ostomy 显示文摘 | Tokue H Takeuchi Y Arai Y | 2011 | J Vase Interv Radiol2011，22，： | 1 |
| 14 | Successful interventional management for subclavian artery injury secondary to internal jugular catheterization:a report of two cases 显示文摘 | Tokue H Tsushima Y Morita H | 2009 | Cardiovasc Intervent Radiol2009，32，6： | 1 |
| 15 | Comparative in vitro activity of carbapenem antibiotics against respiratory pathogens isolated between 1999 and 2000显示文摘 | WATANABE A TOKUE Y TAKAHASHI H | 2001 | Infect Chemother2001，7，： | 1 |
| 16 | Compara tive in-vitro activity of carbapenem antibiotics against re spiratory pathogens isolated between 1999 and 2000显示文摘 | Watanabe A Tokue Y Takahashi H | 2001 | J Infect Chemother2001，7，4： | 1 |
| 17 | Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species显示文摘 | TANAKA J TOKU K ZHANG B | 1999 | Gila1999，28，2： | 1 |
| 18 | Comparison of a PCR assay and a conventional microbiologic method for detection of MRSA 显示文摘 | Tokue Y Shoji S Satoh K | 1992 | Antimicrob Agens Chemother1992，36，1： | 1 |
| 19 | High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA显示文摘 | Mazzariol A Tokue Y Kanegawa TM | | 0，，： | 1 |
| 20 | Biomass nutrient profiles of three microalgae: Spirulina platensis, Chlorella vulgaris, and Isochrisis galbana 显示文摘 | Toku?oglu ? üunal M K | 2003 | Journal of Food Science2003，68，4： | 1 |
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