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| 1 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 2 | locking vursus nonlocking Tpiates for dorsally and volar fixation of dorsally comminuted distal radius fracture s: a biomechanical study显示文摘 | TREASE C MCLFF T TOBY E B | 2005 | J hand surg Am2005，30，4： | 1 |
| 3 | Locking versus nonlocking T-plates for dorsal and volar fixation of dorsally comminu- ted distal radius fractures: a biomechanical study 显示文摘 | Treasc C McIff T Toby E B | 2005 | J Hand Surg Am2005，30，4： | 1 |
| 4 | Assessment of intermediate severity coronary lesions in the catheterization laboratory显示文摘 | Tobis J Azarbal B Slavin L | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 5 | EXPGUI, a graphical user interface for GSAS显示文摘 | TOBY B H | 2001 | Journal of Applied Crystallogra- phy2001，34，2： | 1 |
| 6 | Locking versus nonlocking T-plates for dorsal and volar fixation of dorsally comminuted distal radius fractures: a biomechanical study显示文摘 | TREASE C MCIFF T TOBY E B | 2005 | J Hand Surg Am2005，30，4： | 1 |
| 7 | EXPGUI, a graphical user interface for GSAS 显示文摘 | Toby B H | 2001 | Journal of Applied Crystallography2001，34，： | 1 |
| 8 | The NIH Stroke Scale Can Establish Cognitive Function after Stroke显示文摘 | Cumming Toby B Blomstrand Christian Bernhardt Julie Linden Thomas | 2010 | Cerebrovascu lar Diseases2010，30，1： | 1 |
| 9 | Association of interatrial shunts and migraine headaches:impact of transcatheter closure显示文摘 | Azarbal B Tobis J Suh W | 2005 | J Am Coll Cardiol2005，45，4： | 1 |
| 10 | A graphical user interface for GSAS 显示文摘 | TOBY B EXPGUI | 2001 | J Appl Crystallogr2001，34，2： | 1 |
| 11 | Persistent epigenetic differences associated with prenatal exposure to famine in humans显示文摘 | Heijmans B T Tobi E W Stein A D | 2008 | Proc Natl Acad Sci U S A2008，105，17： | 1 |
| 12 | Assessment of intermediate severity coronary lesions in the catheterization lahoratory显示文摘 | Tobis J Azarbal B Slavin L | 2007 | J Am Coll Cardiol2007，49，8： | 1 |
| 13 | Development of a novel wind turbine simulator for wind energy conversion systems using an inverter-controlled induction motor显示文摘 | Hossein M K Chang Liuchen Tobie B | 2004 | IEEE Trans on Energy Conversion2004，19，3： | 1 |
| 14 | Development of a novel wind turbine simulator for wind energy conversion systems using an inverter-controlled induction motor显示文摘 | Hossein M K Chang Liuchen Tobie B | 2004 | IEEE Trans on Energy Conversion2004，19，3： | 1 |
| 15 | Locking versus nonlocking T-pIatesfor dorsal and volar fixation of dorsaily comminuted distal radiusfractures:a biomechanical study显示文摘 | Trease C McIff T Toby E B | 2005 | J Hand Surg Am2005，30，4： | 1 |
| 16 | Assessment of intermediate severity coronary lesions in the catheterization laboratory显示文摘 | Tobis J Azarbal B Slavin L | 2007 | J Am Coll Cardiol2007，49，8： | 1 |
| 17 | Persistent epigenetic differences associated with prenatal exposure to famine in humans 显示文摘 | HEIJMANS B T TOBI E W STEIN A D | 2008 | Proceedings of the Natlional Academy of Sciences of the United States of America2008，105，17： | 1 |
| 18 | Assessment of intermediate severity coronary lesions in the catheterization laboratory 显示文摘 | Tobis J Azarbal B Slavin L | 2007 | J Am Coil Cardio12007，49，8： | 1 |
| 19 | EXPGUI, a graphical user interface for GSAS 显示文摘 | Toby B H | 2001 | Journal of AppliedCryslallography2001，34，2： | 1 |
| 20 | 显示文摘 | Toby B H | 2001 | Journal of Applied Crystallography2001，34，： | 1 |
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