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| 1 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005,4,3: | 3 |
| 2 | Synthesis of Polycaprolactone with Two Carboxyl End Groups显示文摘At 225℃. caprolactone has been polymerized in the presence of succinic acid under dry nitrogen atmosphere. Characterizations of the polymer through IR and molecular weight measurements by 1H-NMR and end group titration have shown that the polycaprolactone obtained is of two carboxyl end groups. The molecular weight of it increases with decreasing of the acid content in the reaction mixture under the same polymerization conditions. With a certain ratio of acid to caprolactone. the maximum of molecular weight of the polymer will be reached at the reaction time of 3h. | Qijin ZHANG Wenying XU and Zhiyong WANG (Dept. of Mater. Sci. & Eng., University of Science and Technology of China, Hefei, 230026, China)(To whom correspondence should be addressed)(Dept. of Modern Chemistry, University of Science and Technology of Ch | 1994 | Journal of Materials Science & Technology1994,10,5: | 2 |
| 3 | Tacrolimus for induction therapy of diffuse proliferative lupus nephritis:an open-labeled pilot study显示文摘 | Mok CC Tong KH To CH | 2005 | Kidney Int2005,68,2: | 1 |
| 4 | Tacrolimus for induction therapy of diffuse proliferative lupus nephritis: an open labeled pilot study显示文摘 | Mok CC Tong KH To CH | 2005 | Kidney Int2005,68,2: | 1 |
| 5 | Neuropsychiatric damage in Southern Chi-nese patients with systemic lupus erythematosus显示文摘 | Mok CC To CH Mak A | 2006 | Medicine(Balti-more)2006,85,4: | 1 |
| 6 | Chloride secretion by bovine ciliary epithelium: a model of aqueous humor formation 显示文摘 | Do CW To CH | 2000 | Invest Ophthalmol Vis Sci2000,41,7: | 1 |
| 7 | Tacrolimus for induction therapy of diffuse proliferative lupus nephritis:An open-labeled pilot study显示文摘 | Mok CC Tong KH To CH | 2005 | Kidney Int2005,68,2: | 1 |
| 8 | Is active glucose transport present in bovine ciliary body epithelium7 显示文摘 | Chuan CY Guggenheim JA To CH | 2007 | Am J Physiol Cell Physio12007,292,3: | 1 |
| 9 | Nitric oxide and hydroxyl radical-induced retinal lipid peroxidation in vitro显示文摘 | Siu AW To CH | 2002 | Clin Exp Optom2002,85,6: | 1 |
| 10 | Tacrolimus for induction therapy of diffuse proliferate Ⅳ lupus nephritis: an openlabeled pilot study显示文摘 | Mok CC Tong KH To CH | 2005 | Kidney Int2005,68,2: | 1 |
| 11 | Treatment of solitary extramedullary plasmacytoma of the stomach with endoscopic submucosal dissection显示文摘 | Park CH Lee SM Kim TO | 2009 | Gut Liver2009,3,4: | 1 |
| 12 | Multimodal therapy including neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin(MVAC) for stage IIB to IV cervical cancer显示文摘 | Dowdy SC Boardman CH Wilson TO et al | 2002 | Am J Obstet Gynecol2002,186,: | 1 |
| 13 | Anisometropia is independently associated with both spherical and cylindrical ametropia显示文摘 | Qin XJ Margrain TH To CH Bromham N Guggenheim JA | 2005 | Invest Ophthalmol Vis Sci2005,46,11: | 1 |
| 14 | Incidence and mortality of systemic lupus erythenmtoms in a Southern Chinese populati~-2006显示文摘 | Mok CC To CH Ho LY e~ a/ | 2008 | J Rhenmato12008,35,10: | 1 |
| 15 | Anti-Müllerian hormone and ovarian reserve in systemic lupus erythematosus显示文摘 | Mok CC Chan PT To CH | 2013 | Arthritis Rheum2013,65,1: | 1 |
| 16 | Tacrolimus for induction therapy of diffuse proliferative lupus nephritis: an open -labeled pilot study显示文摘 | Mok CC Tong KH To CH | 2005 | Kidney Int2005,68,: | 1 |
| 17 | Tacrolimus for induaion therapy of diffuse proliferative lupus nephritis:An open-labeled pilot study显示文摘 | Mok CC Tong KH To CH | 2005 | Kidney International2005,68,: | 1 |
| 18 | Effects of rosuvastatin on vascu- lar biomarkers and carotid atherosclerosis in lupus: a randomized, double-blind, placebo-controlled trial 显示文摘 | Mok CC Wong CK To CH | 2011 | Arthritis Care Res ( Hoboken)2011,63,6: | 1 |
| 19 | Tacrolimus for induction therapy of diffuse proliferative lupus nephritis: an open-labeled pilot study显示文摘 | Mok CC Tong KH To CH | 2005 | Kidney Int2005,68,2: | 1 |
| 20 | Oonversion of extern&l intr&medullary nailing for fr&ctures of the shaft of the femur njured p&tients显示文摘 | ffx&tJon to Nowot&rskf PJ Turen CH Brumb&ck EJ et &l | 2000 | J Bone Joint Surg(AM)2000,82,6: | 1 |