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| 1 | Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds显示文摘Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and polysaccharides.Over the last decades,seaweed-derived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological conditions.Therefore,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative disorders.In particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory properties.Though,the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more interest.In this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols. | Melissa Schepers Nikita Martens Assia Tiane Kenneth Vanbrabant Hong-Bing Liu Dieter Lütjohann Monique Mulder Tim Vanmierlo | 2020 | Neural Regeneration Research2020，15，5： | 1 |
| 2 | A perspective on causality assessment in epigenetic research on neurodegenerative disorders显示文摘Epigenetics refers to herita ble and reversible processes regulating gene expression that do not involve a change to the DNA sequence.Epigenetic modifications include DNA modifications(e.g.DNA methylation a nd hydroxymethyl at ion),histone modifications,and non-coding RNAs such as micro RNAs and long-coding RNAs(Holtzman and Gersbach. | Philippos Koulousakis Assia Tiane Niels Hellings Jos Prickaerts Daniel van den Hove Tim Vanmierlo | 2023 | Neural Regeneration Research2023，18，2： | 0 |
| 3 | Novel insights in phosphodiesterase 4 subtype inhibition to target neuroinflammation and stimulate remyelination显示文摘In neurodegenerative and classically demyelinating disorders such as multiple sclerosis(MS),spinal cord injury(SCI),stroke,and Charcot-Marie-Tooth disease,glial functioning is compromised and nervous tissue integrity is lost.Recently,primary neurodegenerative disorders such as Alzheimer’s disease,amyotrophic lateral sclerosis(ALS),and Parkinson’s disease(PD)are increasingly linked to impaired oligodendroglia functioning upon neurodegeneration.Due to the destructive micro-environment created by nervous tissue damage,the progressive cellular loss in these disorders,and the amitotic nature of neurons,spontaneous endogenous repair process are limited in nature.Hence,there is a medical need for efficient therapeutic strategies capable of supporting neuro-reparative processes to occur,likely supported by improved oligodendroglia cell functioning. | Melissa Schepers Tim Vanmierlo | 2024 | Neural Regeneration Research2024，19，3： | 0 |
| 4 | Corrigendum:Edible seaweed-derived constituents:an undisclosed source of neuroprotective compounds显示文摘Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and polysaccharides.Over the last decades,seaweedderived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological conditions.Therefore,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative disorders.In particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory properties.Though,the antiinflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more interest.In this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols. | Melissa Schepers Nikita Martens Assia Tiane Kenneth Vanbrabant Hong-Bing Liu Dieter Lütjohann Monique Mulder Tim Vanmierlo | 2021 | Neural Regeneration Research2021，16，12： | 0 |
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