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| 1 | Enrichment factors and sweep spot evaluation of Jurassic tight oil in central Sichuan Basin,SW China显示文摘The secondary migration mechanism,enrichment factors of Jurassic tight oil in central Sichuan Basin were well investigated through physical simulation experiment of reservoir formation,casting and fluorescent thin sections,field emission scanning electron microscope(FESEM)and environment scanning electron microscope(ESEM).The results show that migration of Jurassic tight oil in central Sichuan Basin is a low-velocity non-Darcy flow through low-efficient migration path under the huge migration driving force,and has three migration and seepage stages,i.e.viscous flow stage,nonlinear seepage stage,and quasi-liner seepage stage.Microscopically,the migration pathway of tight oil is the porefracture composite conduction;macroscopically,the migration mode of tight oil is the large-scale shortedistance migration.Distribution of favorable zones of tight oil is controlled by distribution of high-quality source rocks.The hydrocarbon-generation strength of 0.4106 t/km2 can be as a threshold to determine favorable zone of tight oil in the study area.The reservoirs with high permeability and high porosity can form tight oil sweet spots,and the development degree of fractures is closely related to well with high yield of tight oil well. | Zhenglian Pang Shizhen Tao Qin Zhang Tianshu Zhang Jiajing Yang Jianwei Fan Miao Yuan | 2019 | Petroleum Research2019，4，4： | 3 |
| 2 | Evaluation Methods of Profitable Tight Oil Reservoir of Lacustrine Coquina: A Case Study of Da'anzhai Member of Jurassic in the Sichuan Basin显示文摘Based on core observation,cast and fluorescent thin sections,FESEM and ESEM,coquina in Da'anzhai Member of Jurassic in Sichuan Basin were examined systematically.Together with production data and logging evaluation,a method for lacustrine coquina evaluation based on geological theory was established up.In the article,two aspects of the study were elaborated,characteristics of favorable reservoirs,and a'five-step'evaluation method for favorable coquina reservoir.According to the correlation between porosity and production data,porosity is not effective in finding high quality coquina reservoir of this area.Whereas micro research of reservoir samples from a high productivity well revealed that sparry coquina is the best lithofacies,with the most developed micro storage space of various kinds.After the favorable reservoir was sorted out,a five-step method evaluating the coquina reservoir was worked out.Correlation ofGR value and rock types suggests that GR<30 API is an effective evaluation parameter in identifying profitable reservoir lithofacies.Meanwhile,the combination of profitable reservoir rock thickness and production data revealed that the reservoirs with the highest potentiality are those with thickness of 3-18 m.Fractures are more developed in faults,folds and structural noses in the study area.Organic acid is discharged massively before the peak of hydrocarbon generation,leading to the formation of dissolution pores in the reservoir.The evaluation of organic acid was made by using the source rock indexes.After evaluating the four factors,and compiling their distribution maps,the maps were overlapped to predict favorable reservoir zones,and 7 first class and 9 second class favorable zones of coquina were picked out. | PANG Zhenglian TAO Shizhen ZHANG Qin ZHANG Bin ZHANG Tianshu YANG Xiaoping WU Yinye FAN Jianwei YUAN Miao | 2020 | Acta Geologica Sinica(English Edition)2020，94，2： | 2 |
| 3 | DNA methylation drives a new path in gastric cancer early detection:Current impact and prospects显示文摘Gastric cancer(GC)is one of the most common and deadly cancers worldwide.Early detection offers the best chance for curative treatment and reducing its mortality.However,the optimal population-based early screening for GC remains unmet.Aberrant DNA methylation occurs in the early stage of GC,exhibiting cancer-specific genetic and epigenetic changes,and can be detected in the media such as blood,gastric juice,and feces,constituting a valuable biomarker for cancer early detection.Furthermore,DNA methylation is a stable epigenetic alteration,and many innovative methods have been developed to quantify it rapidly and accurately.Nonetheless,large-scale clinical validation of DNA methylation serving as tumor biomarkers is still lacking,precluding their implementation in clinical practice.In conclusion,after a critical analysis of the recent existing literature,we summarized the evolving roles of DNA methylation during GC occurrence,expounded the newly discovered noninvasive DNA methylation biomarkers for early detection of GC,and discussed its challenges and prospects in clinical applications. | Xinhui Wang Yaqi Dong Hong Zhang Yinghui Zhao Tianshu Miao Ghazal Mohseni Lutao Du Chuanxin Wang | 2024 | Genes & Diseases2024，11，2： | 0 |
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