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| 1 | Electro-acupuncture to prevent prolonged postoperative ileus:A randomized clinical trial显示文摘AIM:To examine whether acupuncture can prevent prolonged postoperative ileus(PPOI)after intraperitoneal surgery for colon cancer. METHODS:Ninety patients were recruited from the Fudan University Cancer Hospital,Shanghai,China. After surgery,patients were randomized to receive acupuncture(once daily,starting on postoperative day 1, for up to six consecutive days)or usual care.PPOI was defined as an inability to pass flatus or have a bowel movement by 96 h after surgery.The main outcomes were time to first flatus,time to first bowel movement, and electrogastroenterography.Secondary outcomes were quality of life(QOL)measures,including pain, nausea,insomnia,abdominal distension/fullness,and sense of well-being. RESULTS:No significant differences in PPOI on day 4 (P=0.71)or QOL measures were found between the groups.There were also no group differences when the data were analyzed by examining those whose PPOI had resolved by day 5(P=0.69)or day 6(P= 0.88).No adverse events related to acupuncture were reported. CONCLUSION:Acupuncture did not prevent PPOI andwas not useful for treating PPOI once it had developed in this population. | M Kay Garcia Joseph S Chiang Bob Thornton J Lynn Palmer Jennifer McQuade Lorenzo Cohen | 2010 | World Journal of Gastroenterology2010，16，1： | 27 |
| 2 | Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors显示文摘AIM: To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett's, use of PPIs, and length of Barrett's segment and duration of PPI use. RESULTS: Barrett's patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett's patients who ceased PPI use for 7 d.Although initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett's patients showed no correlation to the amount of Barrett's tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett's mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett's patients reflects their PPI use and not their Barrett's tissue per se . | Christopher Farrell Melissa Morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano James J Thornton Mary Carmen Valenzano James M Mullin | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 3 | Using a neural network and spatial clustering to predict the location of active sites in enzymes显示文摘 | Gutteridge A Bartlett G J Thornton J M | 2003 | Journal of Molecular Biology2003，330，4： | 1 |
| 4 | Rosuvastatin calcium显示文摘 | Quirk J Thornton M Kirkpatrick P | 2003 | Nature Reviews Drug Discovery2003，2，10： | 1 |
| 5 | AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure显示文摘 | Thornton C Bright N J Sastre M | 2011 | Biochem J2011，434，3： | 1 |
| 6 | The distribution of estrogen receptor beta is distinct to that of estrogen receptor alpha and the androgen receptor in human skin and the pilosebaceous unit显示文摘 | THORNTON M J TAYLOR A H MULLIGAN K | 2003 | J Investig Dermatol Symp Proc2003，8，1： | 1 |
| 7 | A Bayesian approach to deformed pattern matching of iris image显示文摘 | Thornton J Sawidos M | 2007 | IEEE Pattern Analysis Machine Intelligence2007，29，4： | 1 |
| 8 | Techniques of coilingcerebral aneurysms显示文摘 | Aletich V A Thornton J etal | 2000 | Surg Neurol2000，53，： | 1 |
| 9 | From genome to function显示文摘 | Thornton J M | 2001 | Science2001，292，5524： | 1 |
| 10 | Continuous and discontinuous protein antigenic determinants显示文摘 | BARLOW D J EDWARDS M S THORNTON J M | 1986 | Nature1986，322，6081： | 1 |
| 11 | Guglielmi detachable coiling for intracranial aneurysms显示文摘 | Misra M Thornton J etal | 2001 | Arch Neurol2001，58，： | 1 |
| 12 | The rapid generation of mutation data matrices from protein sequences显示文摘 | JONES D T TAYLOR W R THORNTON J M | 1992 | Comput Appl Biosci1992，18，： | 1 |
| 13 | Prediction of the location and type of 显示文摘 | Shepherd A J Gorse D Thornton J M | 1999 | Protein Science1999，8，5： | 1 |
| 14 | Analysis of in vitro activities of herpes simplex virus type 1 UL42 mutant proteins : correlation with in vivo function 显示文摘 | THORNTON K E CHAUDHURI M MONAHAN S J | 2000 | Virology2000，275，2： | 1 |
| 15 | Optimizing an Array of Antennas for Cellular Coverage from High Altitude Platform显示文摘 | Thornton J Grace D Capstick M H | 2003 | IEEE Transactions on Wireless Communications2003，2，3： | 1 |
| 16 | Speech-discrimination scores modeled as a binomial variable 显示文摘 | Thornton A R Raffin M J | 1978 | J Speech Hear Res1978，21，3： | 1 |
| 17 | A local search approach to modeling and solving interval algebra problems显示文摘 | THORNTON J BEAUMONT M SATTAR A | 2004 | Journal of Logic and Computation2004，14，1： | 1 |
| 18 | Numerical simulations of agglomerate impact breakage显示文摘 | Thornton C Ciomocos M T Adams M J | 1999 | Powder Technology1999，105，13： | 1 |
| 19 | AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure显示文摘 | Thornton C Bright N J Sastre M | 2011 | Biochem J2011，434，3： | 1 |
| 20 | Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity显示文摘 | Oliva R Calamita G Thornton J M | 2010 | Proc Natl Acad Sci U S A2010，107，9： | 1 |
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