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| 1 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 2 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 3 | Monoclonal immunoglobulin a antibody to the major outer membrane protein of the chlamydia trachomatis mouse pneumonitis biovar protects mice against a chlamydial genital challenge显示文摘 | Pal S Theodor I Peterson EM | 2004 | Vaccine2004，15，5： | 1 |
| 4 | Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection 显示文摘 | Barteneva N Theodor I Peterson EM | 1996 | Infect Immun1996，64，11： | 1 |
| 5 | Encapsulation of nanosized silica by in situ polymerization of tert-butyl acrylate monomer显示文摘 | Sondi I Theodore H Fedynyshyn | 2000 | Langmuir2000，16，23： | 1 |
| 6 | Phase equilibria of mixtures containing chain molecules predicted through a novel simulation scheme显示文摘 | Spyriouni T Economou I G Theodorou D N | 1998 | Physical Review Letters1998，80，20： | 1 |
| 7 | Wind loads on free-standing canopy roofs: part 1 local wind pressures显示文摘 | Yasushi U Theodore S Eri I | 2008 | Journalof WindEngineering and Industrial Aerodynamics2008，96，6： | 1 |
| 8 | Ru l e-B a s e d Cont ex tAssessment in Smart Cities显示文摘 | Beibei Hu Theodore Patkos AbdelghaniCh i b a n i Ya c i ne A m i r a t | 2012 | Web Reasoning andRule Systems Lecture Notes in Computer Science2012，，7497： | 1 |
| 9 | Wind loads on free-standing canopy roofs: part 2 overall wind forces显示文摘 | Yasushi U Theodore S Eri I | 2008 | Journal of WindEngineering and Industrial Aerodynamics2008，96，6： | 1 |
| 10 | Distribution of polyeyelic aromatic hydrocarbons in Datuo karst Tiankeng of South China 显示文摘 | THEODORE O I QI S H KONG X S | 2008 | Environmental Geochemistry and Health2008，30，5： | 1 |
| 11 | CCR5 delta 32 deletion and response to highly active antiretroviral therapy in HIV-l-infected patients显示文摘 | Guerin S Meyer L Theodorou I | 2000 | AIDS2000，14，17： | 1 |
| 12 | Polymorphisms in CCR5 chemokine receptor gene in Japan 显示文摘 | Liu H Nakayama EE Theodorou I | 2007 | Int J Immunogenet2007，34，5： | 1 |
| 13 | Broodstock management and spawning of southern flounder Paralichthys lethostigma显示文摘 | Theodore I J Mcvey D C Jenkins W E | 1999 | Aquaculture1999，，176： | 1 |
| 14 | Jam Chen Soc显示文摘 | RanasingheMahinda I Varnavski Oleg P Pawlas Jan Hauck Sheila I Janis Louie Hartwig John F and Theodore Goodson | 2002 | 124:6520-65212002，124，： | 1 |
| 15 | Fetal death after trauma in pregnancy显示文摘 | Theodorou DA Velmahos GC Souter I | 2000 | Am Surg2000，66，9： | 1 |
| 16 | Monoclonal antibod- y to the major outer membrane protein of the chlamydia trachomatis mouse pneumonitis biovar protects mice a- gainst a chlamydial genital ehallenge显示文摘 | Pal S Theodor I Peterson E M | 2004 | Vaccine2004，15，5： | 1 |
| 17 | Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals显示文摘 | Magierowska M Theodorou I Debre P | 1999 | Blood1999，93，： | 1 |
| 18 | Encapsulation of nanosized silica by in situ polymerization of tert-butyl acrylate monomer显示文摘 | Sondi I Theodore H F Sinta R Matijevic E | 2000 | Langmuir2000，16，23： | 1 |
| 19 | Nucleation of Ti-Catalyzed Self-Assembled Kinked Si Nanowires Grown by Gas Source MBE显示文摘 | Liu X Theodore I | 2003 | JCryst Growth2003，251，1： | 1 |
| 20 | Computer simulation of gas generation and transport in landfills Ⅰ: Quasi-steady-state condition显示文摘 | MEHRDAD H HALIL I K THEODORE T T | 2002 | Chemical Engineering Science2002，57，13： | 1 |
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