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| 1 | Multimedia data-embedding and watermarking technologies 显示文摘 | Swanson M Kobayashi M Tewfik A | 1998 | Proceedings of the IEEE1998，86，6： | 2 |
| 2 | High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD) is a common cause of liver disease worldwide and is a growing epidemic. A high ratio of omega-6 fatty acids to omega-3 fatty acids in the diet has been implicated in the development of NAFLD. However, the inflicted cellular pathology remains unknown. A high ratio may promote lipogenic pathways and contribute to reactive oxygen species(ROS)-mediated damage, perhaps leading to mitochondrial dysfunction.Therefore, these parameters were investigated to understand their contribution to NAFLD development.AIM To examine the effect of increasing ratios of omega-6:3 fatty acids on mitochondrial function and lipid metabolism mediators.METHODS Hep G2-derived VL-17 A cells were treated with normal(1:1, 4:1) and high(15:1,25:1) ratios of omega-6: omega-3 fatty acids [arachidonic acid(AA):docosahexaenoic acid(DHA)] at various time points. Mitochondrial activity and function were examined via MTT assay and Seahorse XF24 analyzer, respectively.Triglyceride accumulation was determined by using Enzy Chrom? and levels of ROS were measured by fluorescence intensity. Protein expression of the mediators of lipogenic, lipolytic and endocannabinoid pathways was assessed by Western blotting.RESULTS High AA:DHA ratio decreased mitochondrial activity(P < 0.01;up to 80%) and promoted intracellular triglyceride accumulation(P < 0.05;40%-70%).Mechanistically, it altered the mediators of lipid metabolism;increased the expression of stearoyl-Co A desaturase(P < 0.05;22%-35%), decreased the expression of peroxisome proliferator-activated receptor-alpha(P < 0.05;30%-40%) and increased the expression of cannabinoid receptor 1(P < 0.05;31%).Furthermore, the high ratio increased ROS production(P < 0.01;74%-115%) and reduced mitochondrial respiratory functions such as basal and maximal respiration, ATP production, spare respiratory capacity and proton leak(P < 0.01;35%-68%).CONCLUSION High AA:DHA ratio induced triglyceride accumulation, increased oxidative stress and disrupted mitochondrial functions. Stimulation of lipogenic and steroidal transcription factors may partly mediate these effects and contribute to NAFLD development. | Reem Ghazali Kosha J Mehta SW Annie Bligh Ihab Tewfik Dahn Clemens Vinood B Patel | 2020 | World Journal of Hepatology2020，12，3： | 2 |
| 3 | Robust Audio Watermarking Using Perceptual Masking显示文摘 | Swanson M D Zhu Bin Tewfik A H | 1998 | Signal Processing1998，66，3： | 1 |
| 4 | Data embedding in audio using time-scale modification显示文摘 | Mansour M F Tewfik A H | 2005 | IEEE Transactions on Speech and Audio Processing2005，13，3： | 1 |
| 5 | Multimedia data embedding and watermarking techniques 显示文摘 | SWANSON M D KOBAYASHI M TEWFIK A H | 1998 | Proceedings of the IEEE1998，86，6： | 1 |
| 6 | Arithmetic coding with dual symbol sets and its performance analysis显示文摘 | Zhu B Yang E H Tewfik A H | 1999 | Image Processing IEEE Transactions on1999，8，12： | 1 |
| 7 | Multimedia Data Embedding and Watermarking Technologies显示文摘 | Swanson D M Kobayashi M Tewfik A H | 1998 | Proceedings of IEEE (S0018-9219)1998，86，7： | 1 |
| 8 | Signal modeling with filtered discrete fractional noise processes显示文摘 | Deriche M Tewfik A H | 1993 | IEEE Trans Signal Processing1993，41，： | 1 |
| 9 | Multiresolut in Scene- Based Video Watermarking UsingPerceptual Models 显示文摘 | Swanson M Zhu B Tewfik A H | 1998 | IEEE1998，，： | 1 |
| 10 | Multimedia Data-embedding and Watermarking Technologies显示文摘 | Swanson M D Kobayashi M Tewfik A H | 1998 | Proceedings of the IEEE1998，86，6： | 1 |
| 11 | Multimedia data-embedding and watermarking Technologies显示文摘 | SWANSON M D KOBAYASHI M TEWFIK A H | 1998 | Proc IEEE1998，86，： | 1 |
| 12 | When seeing isn't believing显示文摘 | Zhu B B Swanson M D Tewfik A H | 2004 | IEEE Signal Process Mag2004，3，： | 1 |
| 13 | Wavelet transform domain LMSalgorithm 显示文摘 | HOSUR S TEWFIK A H | 1993 | IEEE Transactions on Signal Processing1993，4，3： | 1 |
| 14 | When seeing isn't believing显示文摘 | Zhu B B Swanson M D Tewfik A H | 2004 | IEEE Signal Processing Magazine2004，21，2： | 1 |
| 15 | The links between allergy and otitis media with effusion显示文摘 | Tewfik TL Mazer B | 2006 | Curr Opin Otolaryngol Head Neck Surg2006，14，3： | 1 |
| 16 | Robust audio watermarking using perceptual masking显示文摘 | Swanson M D Ahu B Tewfik A H | 1998 | Signal Processing1998，66，3： | 1 |
| 17 | Correlation structure of the discrete wavelet coefficients of fractional Brown motion显示文摘 | Tewfik A H Kim M | 1992 | IEEE Transactions on Information Theory1992，38，2： | 1 |
| 18 | Robust Audio Watermarking Using Perceptual Masking显示文摘 | Swanson D Zhu B Tewfik H | 1998 | Signal Processing1998，66，6： | 1 |
| 19 | Geometric invariance in image watermarking显示文摘 | Masoud Alghoniemy AHMED H Tewfik | 2004 | IEEE Transactions on Image Processing2004，13，2： | 1 |
| 20 | Design and analysis of post-coded OFDM systems显示文摘 | Shah S F A Tewfik A H | 2008 | IEEE Transactions on Wireless Communications2008，12，7： | 1 |
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