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| 1 | Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation显示文摘Splenomegaly is a well-known phenomenon typically associated with inflammation.However,the underlying cause of this phenotype has not been well characterized.Furthermore,the splenomegaly phenotype seen in lymphotoxin(LT)signaling-deficient mice is characterized by increased numbers of splenocytes and splenic neutrophils.Splenomegaly,as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues,is thought to result from the absence of secondary lymphoid tissues in LT-deficient mice.We now present evidence that mice deficient in LTα1β2 or LTβR develop splenomegaly and increased numbers of lymphocytes in non-lymphoid tissues in a microbiota-dependent manner.Antibiotic administration to LTα1β2-or LTβR-deficient mice reduces splenomegaly.Furthermore,re-derived germ-free Ltbr−/−mice do not exhibit splenomegaly or increased inflammation in non-lymphoid tissues compared to specific pathogen-free Ltbr−/−mice.By using various LTβ-and LTβR-conditional knockout mice,we demonstrate that retinoic acid-related orphan receptorγT-positive type 3 innate lymphoid cells provide the required active LT signaling to prevent the development of splenomegaly.Thus,this study demonstrates the importance of LT-mediated immune responses for the prevention of splenomegaly and systemic inflammation induced by microbiota. | Yuan Zhang Tae-Jin Kim Joanna A Wroblewska Vera Tesic Vaibhav Upadhyay Ralph R Weichselbaum Alexei V Tumanov Hong Tang Xiaohuan Guo Haidong Tang Yang-Xin Fu | 2018 | Cellular & Molecular Immunology2018，15，7： | 3 |
| 2 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | Ultrasonographic differentiation of benign from malignant neck lymphadenopathy in thyroid cancer显示文摘 | Kuna SK Bracic I Tesic V | 2006 | J Ultrasound Med2006，25，12： | 1 |
| 4 | Large-Scale Concept Ontology for Multimedia显示文摘 | Naphade M Smith J R Tesic J | 2006 | Multimedia IEEE2006，13，3： | 1 |
| 5 | Ultrasonographic differentiation of benign from malignant neck lymphadenopathy in thyroid cancer显示文摘 | Kuna SK Bracic I Tesic V | 2006 | J Ultrasound Med2006，25，12： | 1 |
| 6 | Effects of spray adjuvants on grape ( Vitis vinifera) berry microflora, epicuticular wax and susceptibility to infection by Botrytis cinema显示文摘 | Rogiers S Y Whitelaw - Weckert M Radovanonic - Tesic M | 2005 | Australasian Plant Pathology2005，34，： | 1 |
| 7 | Exact collision detection using virtual objects in virtual reality modeling of a manufacturing process显示文摘 | Rade Tesic Pat Banerjee | 1999 | Journal of Manufacturing Systems1999，18，5： | 1 |
| 8 | Large-scale concept ontology for multimedia显示文摘 | Naphade M Smith J R Tesic J | | 0，，03： | 1 |
| 9 | Predictors of diabetic cardiomyo- pathy in asymptomatic patients with type 2 diabetes 显示文摘 | Mitrovic JPS Seferovic PM Tesic BV | 2012 | Int J Cardiol2012，156，2： | 1 |
| 10 | The role of glycemia in acute heart failure patients显示文摘 | Seferovic JP Milinkovic I Tesic M | 2014 | Clin Chem Lab Med2014，52，10： | 1 |
| 11 | Exact collision detection using virtual object in virtual reality modeling of a manufacturing process显示文摘 | Rade Tesic Pa Banerjee | 1999 | Journal of Manufacturing System1999，18，5： | 1 |
| 12 | Full field digital mammography scanner显示文摘 | Tesic MM etal | 1997 | European Journal of Radiology1997，31，： | 1 |
| 13 | Exact collision detection using virtual object in virtual reality modeling of a manufacturing process显示文摘 | Rade Tesic Pa Banerjee | 1999 | Journal of Manufacturing System1999，18，5： | 1 |
| 14 | Ultrasonographic differentiation of benign from malignant neck lymphadenopathy in thyroid cancer 显示文摘 | Kuna SK Bracic I Tesic V | 2006 | J Ultrasound Med2006，25，12： | 1 |
| 15 | Ultrasonographic differentiation of benign from malignant neck lymphadenopathy in thyroid cancer 显示文摘 | Kuna SK Bracic I Tesic V | 2006 | J Ultrasound Med2006，25，12： | 1 |
| 16 | The use of intracoronary sodium nitroprusside to treat no - reflow after primary percutaneous coronary intervention in acute myocardial infarction 显示文摘 | Tesic MB Stankovie G Vukcevic V | 2010 | Herz2010，35，2： | 1 |
| 17 | Ultrasonographic differ- entiation of benign from malignant neck lympbadenopathy in thyroid cancer 显示文摘 | Kuna SK Bracic I Tesic V | 2006 | J Ultrasound Med2006，25，12： | 1 |
| 18 | Ultrasonographic dif- ferentiation of benign from malignant neck lymphade- nopathy in thyroid cancer显示文摘 | Kuna SK Bracic I Tesic V | 2006 | J Ultrasound Med2006，25，12： | 1 |
| 19 | The impact of diabetes mellitus on the course and outcome of pregnancy during a 5- year follow-up显示文摘 | Mitrovic M Stojic S Tesic DS | 2014 | Vojnosanit Pregl2014，71，10： | 1 |
| 20 | Ultrasonographic differentiation of benign from malignant neck lymphadenopathy in thyroid cancer显示文摘 | Kuna SK Bracic I Tesic V | 2006 | J Ultrasound Med2006，25，12： | 1 |
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