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| 1 | Old game, new players: Linking classical theories to new trends in transplant immunology显示文摘The evolutionary emergence of an efficient immune system has a fundamental role in our survival against pathogenic attacks. Nevertheless, this same protective mechanism may also establish a negative consequence in the setting of disorders such as autoimmunity and transplant rejection. In light of the latter, although research has long uncovered main concepts of allogeneic recognition, immune rejection is still the main obstacle to long-term graft survival. Therefore, in order to define effective therapies that prolong graft viability, it is essential that we understand the underlying mediators and mechanisms that participate in transplant rejection. This multifaceted process is characterized by diverse cellular and humoral participants with innate and adaptive functions that can determine the type of rejection or promote graft acceptance. Although a number of mediators of graft recognition have been described in traditional immunology, recent studies indicate that defining rigid roles for certain immune cells and factors may be more complicated than originally conceived. Current research has also targeted specific cells and drugs that regulate immune activation and induce tolerance. This review will give a broad view of the most recent understanding of the allogeneic inflammatory/tolerogenic response and current insights into cellular and drug therapies that modulate immune activation that may prove to be useful in the induction of tolerance in the clinical setting. | Marina Burgos da Silva Flavia Franco da Cunha Fernanda Fernandes Terra Niels Olsen Saraiva Camara | 2017 | World Journal of Transplantation2017，7，1： | 1 |
| 2 | Electrical properties of individual cells isolated from adult rat ventricular myocardium显示文摘 | Powell T Terra DA Twist VW | 1980 | J Physiol1980，320，： | 1 |
| 3 | Electrical properties of individual cells isolated from adult rat ventricular myocardium显示文摘 | Powell T Terra DA Twist VW | 1980 | J Physiol1980，320，17： | 1 |
| 4 | Electrical properties of individual cells isolated from adult rat ventricular myocardium显示文摘 | Powell T Terra DA Twist VW | 1980 | J Physiol1980，320，： | 1 |
| 5 | Effect of the ingestion of the palm oil and glutamine in serum levels of GLP-1, PYY and glycemia in diabetes mellitus type 2 patients submitted to metabolic surgery 显示文摘 | Takeuti TD Terra GA da Silva AA | 2014 | Arq Bras Cir Dig2014，27，1： | 1 |
| 6 | Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study显示文摘Objective::Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth characteristics.Methods::Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth characteristics.Results::Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before 2015.Conclusion::This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future. | Juliana Herrero da Silva Ana Claudia Pereira Tercas-Trettel Juliano Andre Boquett Giovanny Vinicius Araujo Franca Augusto Cesar Cardoso-dos-Santos Marina Atanaka Marcelo Zagonel Oliveira Anna Pires Terra Viviane Karoline Vivi Lucia Andreia Nunes de Oliveira Lucia Schaedler Ronaldo Fernandes Santos Alves Lavinia Schuler-Faccini | 2022 | Reproductive and Developmental Medicine2022，6，2： | 0 |
| 7 | Cecum Dieulafoy's Lesion Presenting with Recurrent Lower Gastrointestinal Bleeding: Case Report显示文摘 | Ludmila Resende Guedes Silas Castro de Carvalho Vitor Nunes Arantes Arthur Manoel Braga de Albuquerque Gomes Daniel Antonio de Albuquerque Terra Nathalia da Silva Braga Nicoly Eudes da Silva Dias | 2018 | Journal of Pharmacy and Pharmacology2018，6，3： | 0 |
| 8 | LAND-USE INTENSIFICATION TRENDS IN THE RIO DE LA PLATA REGION OF SOUTH AMERICA:TOWARD SPECIALIZATION OR RECOUPLING CROP AND LIVESTOCK PRODUCTION显示文摘The Rio de la Plata region comprises central Argentina,Uruguay,and southern Brazil.Modern agriculture developed around 1900 with recent decades being characterized by the advance of cropping areas over native grasslands.Highly specialized agriculture has decoupled crop and livestock production but has succeeded in intensifying yields.However,significant losses of ecosystem services have been reported.Thus,questions have been raised on the sustainability of this pathway.A glance at world regions that have experienced similar trends suggests that an urgent course correction is needed.A major concern has been the lack of diversity in regions with highly specialized agriculture,promoting renewed interest in integrated crop-livestock systems(ICLS),not only because ICLS are more diverse than specialized systems,but also because they are rare examples of reconciliation between agroecosystem intensification and environmental quality.Consequently,this paper discusses alternatives to redesign multifunctional landscapes based on ICLS.Recent data provide evidence that recoupling crop and animal production increases the resilience of nutrient cycling functions and economic indicators to external stressors,enabling these systems to face climate-market uncertainty and reconcile food production with the provision of diverse ecosystem services.Finally,these concepts are exemplified in case studies where this perspective has been successfully applied. | Paulo César DE FACCIO CARVALHO Jean Víctor SAVIAN Tomas DELLA CHIESA William DE SOUZA FILHO JoséAlfredo TERRA Priscila PINTO Amanda POSSELT MARTINS Sebastian VILLARINO Júlio Kuhn DA TRINDADE Pedro Arthur DE ALBUQUERQUE NUNES Gervasio PIÑEIRO | 2021 | Frontiers of Agricultural Science and Engineering2021，8，1： | 0 |
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