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| 1 | Self-reported risk of stroke and factors associated with underestimation of stroke risk among older adults with atrial fibrillation: the SAGE-AF study显示文摘Background Though engaging patients with atrial fibrillation(AF) in understanding their stroke risk is encouraged by guidelines, little is known regarding AF patients' perceived stroke risk or its relationship with oral anticoagulation(OAC) use. We aim to identify factors associated with underestimation of stroke risk among older patients with AF and relate this to OAC use. Methods Data are from the ongoing SAGE(Systematic Assessment of Geriatric Elements)-AF study, which included older patients(> 65 years) with non-valvular AF and a CHA2 DS2-VASc score of ≥ 2. Participants reported their perceived risk of having a stroke without OAC. We compared the perceived risk to CHA2 DS2-VASc predicted stroke risk and classified participants as 'over' or 'under' estimators, and identified factors associated with underestimation of risk using multiple logistic regression. Results The average CHA2 DS2-VASc score of 915 participants(average age: 75 years, 47% female, 86% white) was 4.3 ± 1.6, 43% of participants had discordant predicted and self-reported stroke risks. Among the 376 participants at highest risk(CHA2 DS2-VASc score ≥ 5), 46% of participants underestimated their risk. Older participants(≥ 85 years) were more likely and OAC treated patients less likely to underestimate their risk of developing a future stroke than respective comparison groups. Conclusions A significant proportion of study participants misperceived their stroke risk, mostly by overestimating. Almost half of participants at high risk of stroke underestimated their risk, with older patients more likely to do so. Patients on OAC were less likely to underestimate their risk, suggesting that successful efforts to educate patients about their stroke risk may influence treatment choices. | Jordy Mehawej Jane Saczynski Jerry H.Gurwitz Hawa O.Abu Benita A.Bamgbade Wei-Jia WANG Tenes Paul Katherine Trymbulak Connor Saleeba Zi-Yue WANG Catarina I.Kiefe Robert J.Goldberg David D.Mc Manus | 2020 | Journal of Geriatric Cardiology2020，17，8： | 2 |
| 2 | Incident frailty and cognitive impairment by heart failure status in older patients with atrial fibrillation: the SAGE-AF study显示文摘Background Atrial fibrillation(AF) and heart failure(HF) frequently co-occur in older individuals. Among patients with AF, HF increases risks for stroke and death, but the associations between HF and incident cognition and physical impairment remain unknown. We aimed to examine the cross-sectional and prospective associations between HF, cognition, and frailty among older patients with AF. Methods The SAGE-AF(Systematic Assessment of Geriatric Elements in AF) study enrolled 1244 patients with AF(mean age 76 years, 48% women) from five practices in Massachusetts and Georgia. HF at baseline was identified from electronic health records using ICD-9/10 codes. At baseline and 1-year, frailty was assessed by Cardiovascular Health Survey score and cognition was assessed by the Montreal Cognitive Assessment. Results Patients with prevalent HF(n = 463, 37.2%) were older, less likely to be non-Hispanic white, had less education, and had greater cardiovascular comorbidity burden and higher CHA2 DS2 VASC and HAS-BLED scores than patients without HF(all P's < 0.01). In multivariable adjusted regression models, HF(present vs. absent) was associated with both prevalent frailty(adjusted odds ratio [a OR]: 2.38, 95% confidence interval [CI]: 1.64-3.46) and incident frailty at 1 year(a OR: 2.48, 95% CI: 1.37-4.51). HF was also independently associated with baseline cognitive impairment(a OR: 1.60, 95% CI: 1.22-2.11), but not with developing cognitive impairment at 1 year(a OR 1.04, 95%CI: 0.64-1.70). Conclusions Among ambulatory older patients with AF, the co-existence of HF identifies individuals with physical and cognitive impairments who are at higher short-term risk for becoming frail. Preventive strategies to this vulnerable subgroup merit consideration. | Wei-Jia WANG Darleen Lessard Jane Saczynski Robert J Goldberg Alan S.Go Tenes Paul Ely Gracia David D McManus | 2020 | Journal of Geriatric Cardiology2020，17，11： | 2 |
| 3 | Antimalarial drug interactions of compounds isolated from Kigelia africana (Bignoniaceae) and their synergism with artemether, against the multidrug-resistant W2mef Plasmodium falciparum strain显示文摘 | Denis Zofou Mathieu Tene Pierre Tane Vincent P. K. Titanji | 2012 | Parasitology Research2012，，2： | 1 |
| 4 | Antimalarial drug interactions of compounds isolated from Kigelia africana (Bignoniaceae) and their synergism with artemether, against the multidrug-resistant W2mef Plasmodium falciparum strain显示文摘 | Denis Zofou Mathieu Tene Pierre Tane Vincent P. K. Titanji | 2012 | Parasitology Research2012，，2： | 1 |
| 5 | Big Data for All:Privacy and User Control in the Age of Analytics 显示文摘 | TENE O POLINETSKY J | 2013 | Northwestern Journal of Technology and Intellectual Property2013，，4： | 1 |
| 6 | High birth weight as a risk factor for childhood obesity显示文摘 | TENE CE | 2003 | Gac Med Mex2003，139，： | 1 |
| 7 | On the value distribution of L-functions from the Selberg class显示文摘 | Matsaǐtene R | 2012 | Translation in J Math Sci2012，，5： | 1 |
| 8 | Privacy in the age of big data: A time for big decisions显示文摘 | Tene O Polonetsky J | 2012 | Stanford Law Review Online2012，64，： | 1 |
| 9 | Big data for all: Privacy and user control in the age of analytics显示文摘 | Tene O Polonetsky J | 2013 | 2013，，： | 1 |
| 10 | Potassium status of some selected soils under different land - use systems in the subhumid Zone of Nigeria 显示文摘 | Tening AS Omueti JI | 1995 | Commun Soil Sci Plant Anal1995，26，56： | 1 |
| 11 | Privacy and Data Protection in Turkey : ( Inching ) Towards a European Framework 显示文摘 | Omer Tene & Yucel Saygin | 2011 | Privacy & Security Law Report 14672011，，10： | 1 |
| 12 | Big Data for all:privacy and user control in the age of analytics显示文摘 | TENE O POLONETSKY J | 2013 | Northwestern Journal of Technology and Intellectual Property2013，，11： | 1 |
| 13 | Electrophysiological abnormalities in type 2 diabetic patients with reduced levels of insulin-like growth factor Ⅰ显示文摘 | Godinez-Gomez R Trujillo-Hemandez B Tene C E | 2006 | J Int Med Res2006，34，1： | 1 |
| 14 | Privacy in the age of big data:a time for big decisions显示文摘 | TENE O POLONETSKY J | 2012 | Stanford Law Review2012，，2： | 1 |
| 15 | Family dysfunc- tion and malnutrition in the elderly显示文摘 | CARRAZCO-PENA K B TENE C E Elizalde AM | 2015 | Rev Med Inst Mex Seguro Soc2015，53，1： | 1 |
| 16 | Electrophysiological abnormalities in type 2 diabetic patients with reduced levels of insulin-like growth factor I显示文摘 | GODINEZ-GOMEZ R TRUJILLO-HEMANDEZ B TENE CE | 2006 | J Int Med Res2006，34，1： | 1 |
| 17 | Potassium status of some selected soils under different land use systems in the subhumid zone of Nigeria显示文摘 | Tening A S Omueti J I | 1995 | Commun Soil Sci Plant Anal1995，26，56： | 1 |
| 18 | A meta-analysis of predictors of seizure freedom in the surgical management of focal cortical dysplasia显示文摘 | Nathan R Dario E Tene C | 2012 | J Neurosurg2012，116，： | 1 |
| 19 | Assessment of patch quality by ladybirds: relative response to conspecifie and heterespecific larval tracks a consequence of habitat similarity显示文摘 | Magro A Tene J N Bastin N | 2007 | Chemoecology2007，17，1： | 1 |
| 20 | A meta-analysis of pre-dictors of seizure freedom,in the surgical management of focalcortical dysplasia显示文摘 | Nathan CR Dario JE Tene AC | 2012 | J Neurosurg2012，116，5： | 1 |
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