| 1 | 痤疮丙酸杆菌激活的toll样受体显示文摘Background: The bacterium Propionibacterium acnes is involved in the induction and maintenance of the inflammatory phase of acne. Recent studies have found that keratinocytes express toll-like receptors (TLRs) implicated in immediate immunity. No studies have, to date, been carried out on the action of P. acnes upon TLR activation in keratinocytes. Objectives: Focusing on the inflammatory phase of acne, to clarify the role of P. acnes in immediate immunity by inducing expression of TLR- 2 and TLR- 4 by keratinocytes. We also studied how the secretion and expression of matrix metalloproteinase (MMP)- 9 is induced by P. acnes. Methods: The work was carried out on two levels: in vivo with the study of the expression of TLR- 2 and TLR- 4 proteins in biopsies of acne lesions and in vitro on cultured keratinocyte monolayers to study the modulating effects of P. acnes on the expression of TLR- 2 and TLR- 4 and also on the expression and secretion of MMP- 9. Results: Our findings reveal that in vivo TLR- 2 and TLR- 4 expression is increased in the epidermis of acne lesions. In vitro, an increase in TLR- 2 and TLR- 4 expression by human keratinocytes occurred in the first hours of incubatio with bacterial fractions as well as an increase of the expression and secretion by the keratinocytes of MMP- 9, which plays a role in inflammation. Conclusions: This work demonstrates that P. acnes induces TLR expression and that this mechanism could play an essential role in acnelinked inflammation. These receptors could be involved notably in acute acne. | Jugeau S. Tenaud I. Knol A.C. B. Dreno 刘艳 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，3： | 1 |
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