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| 1 | Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC) is the fourth cause of cancer death with an overall survival of 5% at five years. The development of PDAC is characteristically associated to the accumulation of distinctive genetic mutations and is preceded by the exposure to several risk factors. Epidemiology has demonstrated that PDAC risk factors may be non-modifiable risks(sex, age, presence of genetic mutations, ethnicity) and modifiable and co-morbidity factors related to the specific habits and lifestyle. Recently it has become evident that obesity and diabetes are two important modifiable risk factors for PDAC. Obesity and diabetes are complex systemic and intertwined diseases and, over the years, experimental evidence indicate that insulin-resistance, alteration of adipokines, especially leptin and adiponectin, oxidative stress and inflammation may play a role in PDAC. Peroxisome proliferator activated receptor-γ(PPARγ) is a nuclear receptor transcription factor that is implicated in the regulation of metabolism, differentiation and inflammation. PPARγ is a key regulator of adipocytes differentiation, regulates insulin and adipokines production and secretion, may modulate inflammation, and it is implicated in PDAC. PPARγ agonists are used in the treatment of diabetes and oxidative stressassociated diseases and have been evaluated for the treatment of PDAC. PPARγ is at the cross-road of diabetes, obesity, and PDAC and it is an interesting target to pharmacologically prevent PDAC in obese and diabetic patients. | Simone Polvani Mirko Tarocchi Sara Tempesti Lapo Bencini Andrea Galli | 2016 | World Journal of Gastroenterology2016，22，8： | 17 |
| 2 | Nuclear receptors and pathogenesis of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is a devastating disease with a median overall survival time of5 mo and the five years survival less than 5%,a rate essentially unchanged over the course of the years.A well defined progression model of accumulation of genetic alterations ranging from single point mutations to gross chromosomal abnormalities has been introduced to describe the origin of this disease.However,due to the its subtle nature and concurring events PDAC cure remains elusive.Nuclear receptors(NR)are members of a large superfamily of evolutionarily conserved ligand-regulated DNA-binding transcription factors functionally involved in important cellular functions ranging from regulation of metabolism,to growth and development.Given the nature of their ligands,NR are very tempting drug targets and their pharmacological modulation has been widely exploited for the treatment of metabolic and inflammatory diseases.There are now clear evidences that both classical ligand-activated and orphan NR are involved in the pathogenesis of PDAC from its very early stages;nonetheless many aspects of their role are not fully understood.The purpose of this review is to highlight the striking connections that link peroxisome proliferator activated receptors,retinoic acid receptors,retinoid X receptor,androgen receptor,estrogen receptors and the orphan NR Nur,chicken ovalbumin upstream promoter transcription factorⅡand the liver receptor homologue-1 receptor to PDAC development,connections that could lead to the identification of novel therapies for this disease. | Simone Polvani Mirko Tarocchi Sara Tempesti Andrea Galli | 2014 | World Journal of Gastroenterology2014，20，34： | 12 |
| 3 | Comparative study ofβ-nickel molybdate phase obtained by conventional precipitation andthe sol-gel method显示文摘 | Kaddouri A Tempesti E Mazzocchia C | 2004 | Materials Research Bulletin2004，39，2： | 1 |
| 4 | 显示文摘 | Garzella C Comini E Tempesti E | 2000 | Sens Actuators B2000，68，： | 1 |
| 5 | 显示文摘 | Tempesti E Giuffre L Renzo F D | 1988 | J Mol Catal1988，45，： | 1 |
| 6 | TiO2 Thin Films by a Novel Sol-gel Processing for Gas Sensor Applications显示文摘 | Garzella C Comini E Tempesti E | 2000 | Sensors and Actuators (B)2000，68，： | 1 |
| 7 | Comparative Study of Nickle Molybdate Phase Obtained by Conventional Precipitation and the Sol-gel Method显示文摘 | Kaddouri A Tempesti E Mazzocchia C | 2004 | Materials Research Bulletin2004，39，45： | 1 |
| 8 | TiOz thin films by a novel sol-gel processing for gas sensor applications 显示文摘 | Carzella C Comini E Tempesti E | 2000 | Sensors and Actuators B2000，68，： | 1 |
| 9 | 显示文摘 | Garzella C Comini E Tempesti E | 2000 | Sens Actuators B2000，68，： | 1 |
| 10 | TiO2 thin films by a novel sol-gel processing for gas sensor applications显示文摘 | Garzella C Comini E Tempesti E | 2000 | Sensors and Actuators B2000，68，： | 1 |
| 11 | On the nodular morphology and mechanical behavior of synthetic foam cured in thermal and microwave fields 显示文摘 | PALUMBO M TEMPESTI E | 1998 | Acta Polymerica1998，49，9： | 1 |
| 12 | POEtic:An electronic tissue for bio-inspired cellular applications 显示文摘 | THOMA Y TEMPESTI G SANCHEZ E | 2004 | Biosystem2004，，76： | 1 |
| 13 | Continuous fast pyrolysis of biomass at high temperature in a fluidized bed reactor显示文摘 | Rapagna S Tempesti E Foscolo P U | 1992 | Journal of Thermal Analysis1992，38，12： | 1 |
| 14 | Propane and isobutane oxidative dehydrogenation with K, Ca and P-doped α-, and β-nickel molybdate catalysts显示文摘 | Kaddouri A Mazzocchia C Tempesti E | 1998 | Appl Catal A1998，169，： | 1 |
| 15 | The effect of particle-matrix interfacial conditions on the compressive elasticity of epoxy resins filled with untreated hollow glass microspheres显示文摘 | Palumbo M Tempesti E | 1997 | Polymers & Polymer Composites1997，5，3： | 1 |
| 16 | Pyrolysis of biomass in a conventional reactor 显示文摘 | Rapagna S Tempesti E Foscolo P U | 1992 | J Thermal Analysis1992，58，： | 1 |
| 17 | Ethanol from hydrogen and carbon monoxide via methanol homologation显示文摘 | Tempesti E Guiffr~ L Zanderighi L | 1987 | International Journal of Hydrogen Energy1987，12，5： | 1 |
| 18 | 显示文摘 | Mazzocchia C Tempesti E | 1999 | Appl Catal Gen A1999，180，： | 1 |
| 19 | Metal Dispersion Dependent Selectivities for SyngasConversion to Ethanol on V2 03 Supported Rhodium显示文摘 | GRONCHI P TEMPESTI E MAZZOCCHIA C | 1994 | Appl Catal A: General1994，120，： | 1 |
| 20 | POEtic: an electronic tissue for bio-inspired cellular applications 显示文摘 | THOMA Y TEMPESTI Y SANCHEZ E | 2004 | Biosystem2004，76，13： | 1 |
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