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| 1 | Profiles of autoimmune hepatitis in Brunei Darussalam显示文摘BACKGROUND:Autoimmune hepatitis(AIH)is a chronic inflammatory disease of the liver.Data on the disease remain scarce in the Southeast Asia region.This study was undertaken to assess the profiles of AIH in Brunei Darussalam.METHODS:Nineteen patients with AIH treated at the hepatology clinic,RIPAS Hospital(up until December 2008)were reviewed.Demographic,laboratory,histologic,clinical,and therapeutic data of the patients were collected.RESULTS:The median age of the 19 patients at diagnosis was 52 years(range 33-70)with a male to female ratio of 1:3.75.All patients were diagnosed with typeⅠAIH.The prevalence rate of the disease was 5.61/100 000 and was higher in the Chinese than in Malays and Indigenous people.Commonly seen presentations were abnormal liver function(52.6%),icteric hepatitis(36.8%),and decompensated liver disease(10.5%).Histologically advanced fibrosis was found in 47.4%and cirrhosis in 21.1%of the patients.Immune-mediated diseases were present in 36.8%.In a follow-up for 31 months(range 0.25-102),three patients died,2 had progressive liver failure and 1 had lymphoma.Complete biochemical response was seen in 75%of the patients,partial response in 12.5%,and no response in 12.5%.HLA DRB1*03(DR3) was detected in 18.2%of the patients and DRB1*04(DR4) in 45.5%.There were significant associations between HLA Cw7(P=0.038)and DQB1*04(P=0.007).CONCLUSIONS:The data of the 19 patients were comparable to those reported in the literature.Most of the patients were found to have abnormal biochemistry.There were significant associations between HLA Cw7 and DQB104,but not between DRB103(DR3)and DRB104(DR4). | Anand Jalihal Pemasari Upali Telisinghe Vui Heng Chong | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 3 |
| 2 | Primary biliary cirrhosis in Brunei Darussalam显示文摘BACKGROUND:Primary biliary cirrhosis(PBC)is an uncommon autoimmune cholestatic disease that predominantly affects women.Certain human leukocyte antigens(HLAs) have been reported to be associated with susceptibility for PBC.We describe the profiles of PBC in Brunei Darussalam. METHODS:All patients with PBC(n=10)were identified from our prospective databases.The HLA profiles(n=9,PBC)were compared to controls(n=65)and patients with autoimmune hepatitis(n=13,AIH). RESULTS:All patients were women with a median age of 51 years(27-83)at diagnosis.The prevalence rate of the disease was 25.6/million-population and the estimated incidence rate varied from 0 to 10.3/million-population per year.Chinese (41.15/million)and the indigenous(42.74/million)groups had higher prevalence rates compared to Malays(22.62/ million).The prevalence among female population was 54.6/ million-population.All patients were referred for abnormal liver profiles.Five patients had symptoms at presentations: jaundice(20%),fatigue(20%),arthralgia(30%)and pruritus (20%).Serum anti-mitochondrial antibody was positive in 80%of the patients.Overlap with AIH was seen in 30%.Liver biopsies(n=8)showed stage I(n=2),II(n=4)and III(n=2) fibrosis.There were no significant differences in the HLA profiles between PBC and AIH.Compared to the controls,PBC patients had significantly more HLA class I alleles specifically B7(P=0.003),Cw7(P=0.002)and Cw12(P=0.007)but not the class II alleles.At a median follow-up of 23.5 months(2 to 108), all patients were alive without evidence of disease progression. CONCLUSIONS:PBC is also a predominant female disorder in our local setting and most had mild disease.The HLA profiles of our patients were different to what have been reported. | Vui Heng Chong Pemasiri Upali Telisinghe Anand Jalihal | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，6： | 2 |
| 3 | Granulomatous mastitis: presentation, treatment and outcome in 43 patients 显示文摘 | Kok KY Telisinghe PU | 2010 | Surgeon2010，8，4： | 1 |
| 4 | Overexpression of EGFR protein in Bruneian lung cancer patients显示文摘 | Han Y H Abdul Hamid M R Telisinghe P U | 2015 | Asian Pac J Cancer Prev2015，16，1： | 1 |
| 5 | Granulomatous mastitis : presentation, treatment and outcome in 43 patients显示文摘 | Kok KY Telisinghe PU | 2010 | Surgeon2010，8，4： | 1 |
| 6 | Granulomatous mastitis: Presentation, treatment and outcome in 43 patients显示文摘 | K.Y.Y. Kok P.U. Telisinghe | 2010 | The Surgeon2010，，4： | 1 |
| 7 | Possible significance of differences in proportions of cytotoxic T cells and B-lineage cells in the tumour-infiltrating lymphocytes of typical and atypical medullary carcinomas of the breast显示文摘 | Lim KH Telisinghe PU Abdullah MS | 2010 | Cancer Immun2010，10，： | 1 |
| 8 | C-ranulomatous mastitis: presentation, treatment and outcome in 43 patients 显示文摘 | Kok K~ Telisinghe PU | 2010 | Surgeon2010，8，4： | 1 |
| 9 | Granulomatous mastitis: presentation, treatment and outcome in 43 patients显示文摘 | Kok KY Telisinghe PU | 2010 | Surgeon2010，8，4： | 1 |
| 10 | Lipoblastoma: clinical features,treatment, and outcome 显示文摘 | Kok KY Telisinghe PU | 2010 | World J Surg2010，34，7： | 1 |
| 11 | Oesophageal ulcers see- ondary to doxycycline and herpes simplex infection in an im- munocompetent patient 显示文摘 | Saravanan T Telisinghe PU Chong VH | 2012 | Singapore Med J2012，53，4： | 1 |
| 12 | Possi ble significance of differences in proportions of cytotoxic T cells and B lineage cells in the tumour infiltrating lymphocytes of typi- cal and atypical medullary carcinomas of the breast 显示文摘 | Kok Haw Jonathan Lim Premasiri Upali Telisinghe | 2010 | Cancer Immunity2010，10，： | 1 |
| 13 | Granulomatous mastitis: presentation,treatment and outcome in43 patients显示文摘 | Kok KY Telisinghe PU | 2010 | Surgeon2010，8，4： | 1 |
| 14 | Lipoblastoma:Clinical features,treatment,andoutcome显示文摘 | Kok KY Telisinghe PU | 2010 | World J Surg2010，34，7： | 1 |
| 15 | Profiles of epstein-barr virus associated gastric carcinomas in brunei darussalam显示文摘 | Yen RL Telisinghe PU Cunningham A | 2015 | Asian Pac J Cancer Prev2015，15，10： | 1 |
| 16 | Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis 显示文摘 | Chong V H Joseph T P Telisinghe P U | 2007 | J Microbiol lmmunol Infect2007，40，4： | 1 |
| 17 | Lipoblastoma: clinical features, treatment, and outcome显示文摘 | Kok K Y Telisinghe P U | 2010 | World J Surg2010，34，7： | 1 |
| 18 | Lipoblastoma:clinical features,treatment,and outcome显示文摘 | Kok K Y Telisinghe P U | 2010 | World J Surg2010，34，7： | 1 |
| 19 | CD8+ lymphocytes and apoptosis in typical and atypical medullary carcinomas of the breast显示文摘 | Nurlaila I Telisinghe P U Ramasamy R | 2013 | Immunol Lett2013，156，12： | 1 |
| 20 | Limbal leproma in lepromatous leprosy显示文摘Dear Sir, W e are writing to you to present an unusual case of leproma growing at the limbus of a lepromatous leprosy patient. This the first report of ocular leprosy in Brunei, where leprosy is extremely rare. Leprosy, otherwise known as Hansen’s disease, is a chronic granulomatous communicable infection caused by Mycobacterium leprae and its genetic variant (Mycobacterium lepromatosis) [1]. A leproma is a superficial, | Irimpan Lazar Francis Nadir Ali Mohamed Ali Pemasiri Upali Telisinghe Nayan Joshi | 2011 | International Journal of Ophthalmology(English edition)2011，4，6： | 0 |
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