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| 1 | Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a major pest native to the Americas that has recently invaded the Old World.Point mutations in the target-site proteins acetylcholinesterase-1(ace-1),voltage-gated sodium channel(VGSC)and ryanodine receptor(RyR)have been identified in S.frugiperda as major resistance mechanisms to organophosphate,pyrethroid and diamide insecticides respectively.Mutations in the adenosine triphosphate-binding cassette transporter C2 gene(ABCC2)have also been identified to confer resistance to Cry IF protein.In this study,we applied a whole-genome sequencing(WGS)approach to identify point mutations in the target-site genes in 150 FAW individuals collected from China,Malawi,Uganda and Brazil.This approach revealed three amino acid substitutions(A201S,G227A and F290V)of S.frugiperda ace-1,which are known to be associated with organophosphate resistance.The Brazilian population had all three ace-1 point mutations and the 227A allele(mean frequency=0.54)was the most common.Populations from China,Malawi and Uganda harbored two of the three ace-1 point mutations(A201S and F290V)with the 290V allele(0.47-0.58)as the dominant allele.Point mutations in VGSC(T929I,L932F and L1014F)and RyR(I4790M and G4946E)were not detected in any of the 150 individuals.A novel 12-bp insertion mutation in exon 15 of the ABCC2 gene was identified in some of the Brazilian individuals but absent in the invasive populations.Our results not only demonstrate robustness of the WGS-based genomic approach for detection of resistance mutations,but also provide insights for improvement of resistance management tactics in S.frugiperda. | Fang Guan Jianpeng Zhang Huiwen Shen Xingliang Wang Amanda Padovan Tom K.Walsh Wee Tek Tay Karl H.J.Gordon William James Cecilia Czepak Michael Hilary Otim Donald Kachigamba Yidong Wu | 2021 | Insect Science2021，28，3： | 6 |
| 2 | Prevalence of obesity and diabetes in patients with schizophrenia显示文摘AIM To compare the prevalence of diabetes in patients with schizophrenia treated at a community mental health center with controls in the same metropolitan area and to examine the effect of antipsychotic exposure on diabetes prevalence in schizophrenia patients. METHODS The study was a comprehensive chart review of psychiatric notes of patients with schizophrenia and schizoaffective disorder treated at a psychosis program in a community mental health center. Data collected included psychiatric diagnoses, diabetes mellitus diagnosis, medications, allergies, primary care status, height, weight, body mass index(BMI), substance use and mental status exam. Local population data was downloaded from the Centers for Disease Control Behavioral Risk Factor Surveillance System. Statistical methods used were χ~2 test, Student's t test, general linear model procedure and binary logistic regression analysis.RESULTS The study sample included 326 patients with schizophrenia and 1899 subjects in the population control group. Demographic data showed control group was on average 7.6 years older(P = 0.000), more Caucasians(78.7% vs 38.3%, P = 0.000), and lower percentage of males(40.7% vs 58.3%, P = 0.000). Patients with schizophrenia had a higher average BMI than the subjects in the population control(32.11, SD = 7.72 vs 27.62, SD = 5.93, P = 0.000).Patients with schizophrenia had a significantly higher percentage of obesity(58.5% vs 27%, P = 0.000) than the population group. The patients with schizophrenia also had a much higher rate of diabetes compared to population control(23.9% vs 12.2%, P = 0.000). After controlling for age sex, and race, having schizophrenia was still associated with increased risk for both obesity(OR = 3.25, P = 0.000) and diabetes(OR = 2.42, P = 0.000). The increased risk for diabetes remained even after controlling for obesity(OR = 1.82, P = 0.001). There was no difference in the distribution of antipsychotic dosage, second generation antipsychotic use or multiple antipsychotic use within different BMI categories or with diabetes status in the schizophrenia group. CONCLUSION This study demonstrates the high prevalence of obesity and diabetes in schizophrenia patients and indicates that antipsychotics may not be the only contributor to this risk. | Aniyizhai Annamalai Urska Kosir Cenk Tek | 2017 | World Journal of Diabetes2017，8，8： | 6 |
| 3 | Frequency control ancillary service provided by a wind farm:dual-BESS scheme显示文摘Network frequency control function is incorporated into a grid-connected wind farm-dual battery energy storage system(BESS)scheme.The design of the scheme takes advantage of the rapid response characteristics of the BESS and the in-built short-term overloading capability of the associated power conversion devices.A control strategy to regulate the BESS output power is then proposed.It is shown that the frequency control action offered by the BESS complements amicably with that of conventional generators in enhancing the frequency regulation attribute of the grid system. | Dailin YAO San Shing CHOI King Jet TSENG Tek Tjing LIE | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，2： | 4 |
| 4 | Climate change adaptation, greenhouse gas mitigation and economic profitability of conservation agriculture: Some examples from cereal systems of Indo-Gangetic Plains显示文摘Achieving sustainability of the cereal system in the Indo-Gangetic Plains(IGP)of India under progressive climate change and variability necessitates adoption of practices and technologies that increase food production,adaptation and mitigation in a sustainable way.This paper examines conservation agriculture(CA)from the perspective of:(i)increased yield and farm income,(ii)adaptation to heat and water stresses,and(iii)reduction in greenhouse gas(GHGs)emissions.The analyses and conclusions are based on the literature and evidences from a large number of on-station as well as farmers’field trials on CA in the cereal systems of IGP.Our analyses show that CA-based system substantially reduces the production cost(up to 23%)but produces equal or even higher than conventional system;thereby increasing economic profitability of production system.CA-based production systems also moderated the effect of high temperature(reduced canopy temperature by 1–4°C)and increased irrigation water productivity by 66–100%compared to traditional production systems thus well adapting to water and heat stress situations of IGP.Our continuous monitoring of soil flux of CO2,N2O and CH4 revealed that CA-based rice-wheat systems emit 10–15%less GHGs than conventional systems.This is the first time that CA and its components are synthesized and analyzed from food security-climate change nexus.From this holistic analysis,we suggest that wide-scale promotion of suitable CA practices by integrating into national agriculture development strategy is a way forward to address food security,climate change adaptation and mitigation challenges faced by present agriculture. | Tek B Sapkota M L Jat Jeetendra P Aryal R K Jat Arun Khatri-Chhetri | 2015 | Journal of Integrative Agriculture2015，14，8： | 4 |
| 5 | Amount and temperature effects responsible for precipitation isotope variation in the southern slope of Himalayas显示文摘Seasonal variation of stable isotopes in precipitation of Kathmandu Valley on the southern slope of Himalaya was carried out to understand the controlling mechanism of amount and temperature effect on the basis of one year stable isotope data from 2010 to 2011. Highly depleted isotope values in major rainy period are obtained just after the onset of precipitation in summer, which accounts for 'amount effect' due to saturation isotopic compositions in high moisture condition, whereas, the higher values in winter are indicative to regional vapors (temperature effect) recycling of various sources. An abrupt depletion of isotope values in mid-June, indicates the onset date of monsoon precipitation, by the replacement of winter air mass with southern monsoon. Thus, precipitation isotopes are a tool revealing the onset date of summer monsoon and temporal features of variability, in local and regional monsoons precipitations. A comparison of long term monthly values of δ 18 O, temperature, and precipitation with GNIP δ 18 O data shows the temporal variations of stable isotopes are mostly controlled by amount and temperature effects. During summer monsoon, the amount effects are stronger for high values of precipitation (R=0.7) and altitude effect appears for low moisture in late rainy season, thus from December to June (winter to pre-monsoon) the controlling features of isotopes remains under the temperature effect. A temporal rate of temperature effect is derived as 0.04‰ per year which indicates a dry signal of atmospheric condition and a temperature relation δ 18 O=(0.371±0.08)T+(0.156±0.05) is obtained from this analysis. The meteoric water lines of Kathmandu before and after monsoon onset of 2011, are found as δD=(4.36±0.3)δ 18 O+(15.66±1.2) and δD=(6.91±0.2)δ 18 O (7.92±2.26) from lab samples result, and δD=9.2δ 18 O+11.725 and δD=8.53δ 18 O+16.65 from GNIP data, which lacks the consistency both for slopes and intercepts values for the study period. The mean lapse rate values of δ 18 O and δD from GNIP data are obtained as 0.002‰/m and 0.015 ‰/m, which indicate the altitudinal effects in regional precipitation of the southern slope of Himalayas. This study estimates new stable isotopes data in recent precipitation using simple methodology which can be important for regional precipitation monitoring systems, environmental change and paleo-climatic studies. | Tek Bahadur Chhetri TanDong Yao LiDe Tian XinPing Zhang | 2013 | Research in Cold and Arid Regions2013，5，2： | 3 |
| 6 | Complications of Fibrin Glue in Pterygium Surgery with Amniotic Membrane Transplant显示文摘Purpose:To compare the complications and the recurrence rate between fibrin glue (TISSEEL) and Vicryl 8-0 sutures in amniotic membrane transplant during pterygium surgery.Methods:Patients who underwent pterygium surgery with amniotic membrane transplant (AMT) in the Wang Eye Clinic (Doraville,USA).were randomly categorized into two groups:one group received TISSEEL and the other group received Vicryl 8-0 sutures.All procedures for both groups were performed by one ophthalmologist.Twenty-four patients (24 eyes) participated in the TISSEEL group (22 eyes with primary surgery and 2 eyes with surgery for recurrence) and 19 patients (19 eyes) took part in the suture group (18 primary eyes and 1 recurrence).The patients with recurrent pterygium in both groups had not received AMT previously.Post-operatively,patients were followed up for one week and then one year to check for any signs of complications and recurrence.Results:Conjunctival inflammation occurred in 3 eyes (12.5%) in the TISSEEL group,and 6 eyes (31.6%) in the suture group.(P<0.05,Chi-square test).In the TISSEEL group,1 eye (4.2%) showed recurrence,while there were no recurrences in the sutures group.There were 3 dry eyes (15.8%) in the suture group and 2 dry eyes (8.3%) in the TISSEEL group (P>0.05).No dislocated conjunctival grafts,Dellen,inflammation,infection,bleeding,pyogenic granuloma,or scleromalacia was observed in either group.Conclusion:Pterygium surgery with AMT had less conjunctival inflammation and dry eye in patients receiving fibrin glue than those with Vicryl 8-0 sutures. | Lan P.Nguyen Zhengxiang Wang Jesley Molina Andrea Tellez Tek Chemoriya | 2012 | Eye Science2012，27，1： | 2 |
| 7 | NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients显示文摘AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations. | Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，41： | 2 |
| 8 | Developing a culturally relevant bioethics for Asian people 显示文摘 | MICHAEL CHENG -TEK TAI CHUNG SENG LIN | 2001 | Journal of Medical Ethics2001，27，1： | 1 |
| 9 | Do children with autism spectrum disorders show a shape bias in word learning? 显示文摘 | Tek S Jaffery G Fein D | 2008 | Autism Res2008，1，4： | 1 |
| 10 | Effect of surfactants and polymers on stability and antibacterial activity of silver nanoparticles (NPs)显示文摘 | Kvítek L Paná(c)ek A Soukupová J | 2008 | Journal of Chemical Physics C2008，112，： | 1 |
| 11 | A computationally effective formulation of the thermodynamic properties of Li Br-H2O solution from 273 to 500 K over full composition range显示文摘 | PáTEK J KLOMFAR J | 2006 | International Journal of Refrigeration2006，29，4： | 1 |
| 12 | Solid-liquid phase equilibrium in the systems of LiBr-H2O and LiCl-H2O显示文摘 | Pátek J Klomfar J | | 0，，1： | 1 |
| 13 | Biodegradation potential of the genus Rhodococcus 显示文摘 | MART~NKOV~ L UHNAKOVJ~ B PJ~tek M | 2009 | Environment International2009，35，1： | 1 |
| 14 | Comparison of two Chlorhexidine rinse protocols on the incidence of alveolar osteitis following the surgical removal of impacted third molars显示文摘 | Metin M Tek M Sener I | 2006 | J Contemp Dent Pract2006，7，2： | 1 |
| 15 | Optimal HDS for lower-sulfur gasoline depends on several factors显示文摘 | Tek Sutikno | 1999 | Oil & Gas Journal1999，97，23： | 1 |
| 16 | The Effectiveness of Price Limits in an Emerging Market: Evidence from the Korean Stock Exchange显示文摘 | Henk Berkman John Byong Tek Lee | 2002 | Pacific-Basin Finance Journal2002，，10： | 1 |
| 17 | Cervical Approach to Substernal Goiter:Do we Need Sternotomy?Cerrahpa?a Experience显示文摘 | Teks?z S Bükey Y Ulusan K | 2013 | Tjem2013，17，4： | 1 |
| 18 | Temperature Offset Drift of GMI Sensors显示文摘 | Malátek M Ripka P Kraus L | 2008 | Sens Actuators A2008，147，： | 1 |
| 19 | Intractable bimaxillary osteomyelitis in osteopetrosis:review of the literature and current therapy显示文摘 | O(g)ütcen-Toller M Tek M Sener I | | 0，，： | 1 |
| 20 | Multiphase flow of water,oil and nature gas through vertical flow strings显示文摘 | Tek M R | 1961 | JPT1961，13，10： | 1 |
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