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| 1 | Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells显示文摘AIM: To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning. METHODS: The in vitro effect of H2O2 pretreatment was investigated in rat isolated hepatocytes subjected to anoxia/reoxygenation. Cell viability was assessed with propidium iodide fluorometry. In other experiments, rat livers were excised and subjected to warm ischemia/ reperfusion in an isolated perfused liver system to determine leakage of liver enzymes. Preconditioning was performed by H2O2 perfusion, or by stopping the perfusion for 10 min followed by 10 min of reperfusion. To inhibit Kupffer cell function or reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, gadolinium chloride was injected prior to liver excision, or diphenyleneiodonium, an inhibitor of NADPH oxidase, was added to the perfusate, respectively. Histological detection of oxygen radical formation in Kupffer cells was performed by perfusion with nitro blue tetrazolium. RESULTS: Anoxia/reoxygenation decreased hepatocyte viability compared to the controls. Pretreatment with H2O2 did not improve such hepatocyte injury. In liver perfusion experiments, however, H2O2 preconditioning reduced warm ischemia/reperfusion injury, which wasreversed by inhibition of Kupffer cell function or NADPH oxidase. Histological examination revealed that H2O2 preconditioning induced oxygen radical formation in Kupffer cells. NADPH oxidase inhibition also reversed hepatoprotection by ischemic preconditioning. CONCLUSION: H2O2 preconditioning protects hepato- cytes against warm ischemia/reperfusion injury via NADPH oxidase in Kupffer cells, and not directly. NADPH oxidase also mediates hepatoprotection by ischemic preconditioning. | Kazuaki Tejima Masahiro Arai Hitoshi Ikeda Tomoaki Tomiya Mikio Yanase Yukiko Inoue Takako Nishikawa Naoko Watanabe Natsuko Ohtomo Masao Omata Kenji Fujiwara | 2007 | World Journal of Gastroenterology2007，13，38： | 2 |
| 2 | Tissue plasminogen activa- tor promotes matrix metalloproteinase-9 upregulation af- ter focal cerebral ischemia显示文摘 | Tsuji K Aoki T Tejima E | 2005 | Stroke2005，36，9： | 1 |
| 3 | Tissue Plasminogen Activator Promotes Matrix Metalloproteinase -9 Upregulation After Focal Cerebral Ischemia 显示文摘 | Tsuji K Aoki T Tejima E | 2005 | Stroke2005，36，9： | 1 |
| 4 | Astrocytic induction of matrix metalloproteinase-9and edema in brain hemorrhage显示文摘 | Tejima E Zhao BQ Tsuji K et a1 | 2007 | J Cereb Blood Flow Metab2007，27，3： | 1 |
| 5 | Rehabilitation robotics: a review显示文摘 | Tejima N | 2001 | Advanced Ro- botics2001，14，7： | 1 |
| 6 | Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia 显示文摘 | TSUJI K AOKI T TEJIMA E | 2005 | Stroke2005，36，9： | 1 |
| 7 | Takotsubo cardiomyopathy with a significant pressure gradient in the left ventricle 显示文摘 | Akashi Yj Tejima T Sakurada H | 2000 | Heart Vessels2000，15，2： | 1 |
| 8 | Hemorrhagic transformation after fibrinolysis with tissue plasminogen activator:evaluation of role of hypertension with rat thromboembolic stroke model显示文摘 | Katayama Y Suzuki Y | 2001 | Stroke2001，32，： | 1 |
| 9 | Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and spleno- megaly 显示文摘 | Tejima K Masuzaki R Ikeda H | 2010 | J Gastroenterol2010，45，8： | 1 |
| 10 | Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke显示文摘 | Zhao BQ Tejima E Lo EH | 2007 | Stroke2007，38，2： | 1 |
| 11 | Characteristics of dioxin emissions at startup and shutdown of MSW incinerators显示文摘 | Hajime Tejima Masahide Nishigaki Yasuyuki Fujita Akihiro Matsumoto Nobuo Takeda Masaki Takaoka | 2006 | Chemosphere2006，，6： | 1 |
| 12 | Hemorrhagic transformation after fibrinolytie therapy with tissue plasminogen activator in a rat thromboembolic model of stroke 显示文摘 | Kano T Katayama Y Tejima E | 2000 | Brain Res2000，854，12： | 1 |
| 13 | Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly显示文摘 | Kazuaki Tejima Ryota Masuzaki Hitoshi Ikeda Haruhiko Yoshida Ryosuke Tateishi Yosuke Sugioka Yukio Kume Tomoko Okano Tomomi Iwai Hiroaki Gotoh Sachiko Katoh Atsushi Suzuki Yukako Koike Yutaka Yatomi Masao Omata Kazuhiko Koike | 2010 | Journal of Gastroenterology2010，，8： | 1 |
| 14 | The pricing of risky debt when interest rates are stochastic显示文摘 | Shimko D C Tejima N Deventer D R V | 1993 | Journal of Fixed Income1993，3，2： | 1 |
| 15 | Neurovascular proteases in brain inju- ry, hemorrhage and remodeling after stroke 显示文摘 | Zhao BQ Tejima E Lo EH | 2007 | Stroke2007，38，2： | 1 |
| 16 | Asttrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage显示文摘 | Tejima E Zhao B Q Tsuji K | 2007 | J cereb Blood Flow Metab2007，27，3： | 1 |
| 17 | The Pricing of Risky Debt When Interest Rates Are Stochastic 显示文摘 | SHIMKO D C TEJIMA N VAN DEVENTER D R | 1993 | The Journal of Fixed Income1993，3，2： | 1 |
| 18 | Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1 显示文摘 | Tejima E Guo S Murata Y et 01 | 2009 | J Neurotrauma2009，26，11： | 1 |
| 19 | The pricing of risky debt when interest rates are stochastic 显示文摘 | SHIMKO D TEJIMA N DEVENTER D V | 1993 | Journal of Fixed Income1993，3，2： | 1 |
| 20 | Tissue plasmino- gen activator promotes matrix metalloproteinase-9 up- regulation after focal cerebral ischemia显示文摘 | Tsuji K Aoki T Tejima E | 2005 | Stroke2005，36，9： | 1 |
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