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| 1 | Prognostic significance of neutrophil to lymphocyte ratio in pancreatic cancer: A meta-analysis显示文摘AIM:To conduct a meta-analysis evaluating theassociation between the peripheral blood neutrophil to lymphocyte ratio(NLR) and the outcome of patients with pancreatic cancer.METHODS:Studies evaluating the relationship between the peripheral blood NLR and outcome of patients with pancreatic cancer published up to May 2014 were searched using electronic databases, including Pub Med, Web of Science, Embase and Ovid.A meta-analysis was performed to pool the hazard ratios(HRs) or odds ratios(ORs) and their 95% confidence intervals(CIs) using either a fixed-effects model or a random-effects model to quantitatively assess the prognostic value of NLR and its association with clinicopathological parameters.RESULTS:Eleven studies containing a total of 1804 patients were eligible according to our selection criteria, and combined hazard ratios indicated that high NLR was a poor prognostic marker for pancreatic cancer patients because it had an unfavorable impact on the overall survival(OS)(HR =2.61, 95%CI:1.68-4.06, P =0.000) and cancer specific survival(HR =1.66, 95%CI:1.08-2.57, P =0.021).Subgroup analysis revealed that high NLR was associated with poor OS in patients with mixed treatment(HR =4.36, 95%CI:2.50-7.61, P =0.000), chemotherapy(HR =2.08, 95%CI:1.49-2.9, P =0.000), or surgical resection(HR =1.2, 95%CI:1.00-1.44, P =0.048).Additionally, high NLR was significantly correlated with tumor metastasis(OR =1.69, 95%CI:1.10-2.59, P =0.016), poor tumor differentiation(OR =2.75, 95%CI:1.19-6.36, P =0.016), poor performance status(OR =2.56, 95%CI:1.63-4.03, P =0.000), high cancer antigen 199(OR =2.62, 95%CI:1.49-4.60, P =0.000), high C-reactive protein(OR =4.32, 95%CI:2.71-6.87, P =0.000), and low albumin(OR =3.56, 95%CI:1.37-9.27, P =0.009).CONCLUSION:High peripheral blood NLR suggested a poor prognosis for patients with pancreatic cancer,and it could be a novel marker of survival evaluation and could help clinicians develop therapeutic strategies for pancreatic cancer patients. | Jian-Jun Yang Zhi-Gao Hu Wu-Xiang Shi Te Deng Song-Qing He Sheng-Guang Yuan | 2015 | World Journal of Gastroenterology2015，21，9： | 15 |
| 2 | Effect of meteorological variables on the incidence of hand, foot, and mouth disease in chil- dren: a time-series analysis in Guangzhou, China 显示文摘 | Huang Yong Deng Te Yu Shicheng | 2013 | BMC Infect Dis2013，13，： | 1 |
| 3 | Muscling through the microR- NA world 显示文摘 | Callis TE Deng Z Chen JF | 2008 | Exp Biol Med ( Maywood)2008，233，2： | 1 |
| 4 | Hmnan Capital Distribution, Growth and Trade 显示文摘 | Cheng - Te Lee and Deng - Shing Huang | 2012 | Bulletin of Economic Research2012，，： | 1 |
| 5 | Muscling through the microRNA world显示文摘 | Callis TE Deng Z Chert JF | 2008 | Exp Biol Med2008，233，2： | 1 |
| 6 | Unconditionedbehavioral effects of the powerful kappa-opioid hallucinogensalvinorin A in nonhuman primates : fast onset and entry intocerebrospinal fluid显示文摘 | Butelman ER Prisinzano TE Deng H | 2009 | J Pharmacol Exp Ther2009，328，2： | 1 |
| 7 | Role of sulfide and ligand strength in controlling nanosilver toxicity显示文摘 | Choi O Cleuenger TE Deng BL | 2009 | Water Research2009，43，7： | 1 |
| 8 | Efficacy of acupuncture as an adjuvant to speech and language therapy for aphasia after ischemic stroke:a protocol of systematic review and meta-analysis显示文摘Background:Aphasia is one of the common complications of stroke.Speech and language therapy is a conventional treatment for aphasia following stroke.However,rehabilitation often remains unsatisfactory after speech and language therapy alone.Acupuncture may be effective for aphasia after stroke.We designed this systematic review to assess the efficacy and safety of acupuncture as an adjunct to speech and language therapy for aphasia following ischemic stroke.Methods:An extensive search will be performed in databases including Cochrane Central Register of Controlled Trials,PubMed,Web of Science,EMBASE,China National Knowledge Infrastructure,Sinomed,Wei Pu Date and Wan Fang Data.No limitation will be set in language,publication date or status of the study.The primary outcomes include scores of Western Aphasia Battery and Aphasia Quotient.The secondary outcomes include Scales of Clinical Rehabilitation Research Center Aphasia Examination,Communicative Abilities in Daily Living,Aphasia Battery of Chinese,Chinese Functional Communication Profile,adverse reactions,etc.Results:All of the data will be processed with Review Manager software.Cochrane‘risk of bias’tool will be used to assess the risk of bias.Conclusion:This study will contribute to the selection of appropriate therapies for aphasia after ischemic stroke and the development of clinical guidelines on this topic. | Bo-Mo Sang Shi-Zhe Deng Ting Hao Kai-Hang Sun Te Ba Jing-Bo Zhai Xiao-Feng Zhao Zhi-Hong Meng | 2021 | Medical Data Mining2021，4，4： | 0 |
| 9 | Proteome-wide epitope mapping identifies a resource of antibodies for SARS-CoV-2 detection and neutralization显示文摘Dear Editor,Since December 2019,the coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has become a worldwide pandemic.1 Significant efforts have been made to generate antibodies to help study COVID-19 pathogenesis,perform diagnostic testing,and develop treatment to neutralize SARS-CoV-2 activity.However,the specific sequence of amino acids recognized and bound by an antibody,the'epitope'is unknown for most antibodies.In this study,we developed a high-throughput epitope mapping platform using a peptide-based SARS-CoV-2 proteome microarray.2 to detect the binding epitopes of 57 commercial antibodies to ORFlab,nudeocapsid(N);spike(S),envelop(E),membrane(M),ORF3a,ORF6,ORF7a,and ORF8 proteins(Supplementary Table S1). | Te Liang Mengli Cheng Fei Teng Hongye Wang Yongqiang Deng Jiahui Zhang Chengfeng Qin Shubin Guo Hui Zhao Xiaobo Yu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 10 | X(3872) and Bound State Problem of D^0*~0(~0 D*~0)显示文摘We have performed a dynamical calculation of the bound state problem of D0D*0 by considering the pion and sigma meson exchange potential. Our preliminary analysis disfavors the molecular interpretation of X(3872) if we use the experimental D*Dπ coupling constant g=0.59 and a reasonable cutoff around 1 GeV,which is the typical hadronic scale. In contrast,there probably exists a loosely bound S-wave BB* molecular state. Such a molecular state would be rather stable since its dominant decay mode is the radiative decay through B*→Bγ. | LIU Yan-rui1,LIU Xiang2,3,DENG Wei-zhen2 (1 Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China 2 Department of Physics,Peking University,Beijing 100871,China 3 Centro de Física Terica,Departamento de Física,Universidade de Coimbra,P-3004-516,Coimbra,Portugal) | 2009 | 原子核物理评论2009，26，S1： | 0 |
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