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| 1 | Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease显示文摘A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood.In the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in hepatocytes.Because of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet fed or murine steatohepatitis,and high-fat or sucrose diet fed models.Although these animal models have provided useful information,none of them accurately reflect genetic,metabolic and biochemical characteristics of the human disease. | Metin Basaranoglu Serra Kayacetin Nevin Yilmaz Ertugrul Kayacetin Orhan Tarcin Abdullah Sonsuz | 2010 | World Journal of Gastroenterology2010，16，18： | 14 |
| 2 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 3 | Serum prolidase and IGF-1 as non-invasive markers of hepatic fibrosis during four different periods after bile-ductligation in rats显示文摘 | Tarcin O Gedik N Karakoyun B | 2008 | Dig Dis Sci2008，53，7： | 1 |
| 4 | Influence of dentin and core porcelain thickness on the color of fully sintered zirconia ceramic restorations显示文摘 | Sinmazisik G Demirbas B Tarcin B | 2014 | Journal of Prosthetic Dentistry2014，111，2： | 1 |
| 5 | Effect of vitamin D defi ciency and replacement on endothelial function in asymptomatic subjects显示文摘 | Tarcin O Yavuz DG Ozben B | 2009 | J Clin Endocrinol Metab2009，94，10： | 1 |
| 6 | The effects of N-acetylcysteine on bile duct ligation-induced liver fibrosis in rats显示文摘 | Tahan G Tarcin O Tahan V | 2007 | Dig Dis Sci2007，52，12： | 1 |
| 7 | Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects显示文摘 | Tarcin OYD Ozben B Telli A | | 0，，10： | 1 |
| 8 | Acustimulation of the neiguan point during gastroscopy: Its effects on nausea and retching显示文摘 | Tarcin O Gurbuz AK Pocan S | 2004 | Turk J Gastroenterol2004，15，4： | 1 |
| 9 | Insulin resistance, adipocyte biology, and thiazolidinediones: a review显示文摘 | Tarcin O Bajaj M Akalin S | 2007 | Metab Syndr Relat Disord2007，5，2： | 1 |
| 10 | Effect of vitamin D deficiency and replacement on endothelial function in asymp- tomatic subjects 显示文摘 | Tarcin O Yavuz DG Ozben B | 2009 | J Clin Endocrinol Metab2009，94，10： | 1 |
| 11 | In vivo inefficiency of pentoxifylline and interferon-alpha on hepatic fibrosis in biliary-ob- structed rats: assessment by tissue collagen content and prolidase activity 显示文摘 | TARCIN O AVSAR K DEMIRTURK L | 2003 | J Gastroenterol Hepatol2003，18，4： | 1 |
| 12 | Effect of vitamin D deficiency and replacement on endothelial function in asymp tomatic subjects editorial comment显示文摘 | TARCIN O YAVUZ D G OZBEN B | 2010 | Obstetrical & Gyneco logical Survey2010，65，3： | 1 |
| 13 | Acustimulation of the Neiguan point during gastroscopy;Its effects on nausea and retching显示文摘 | Tarcin O Gurbuz AK Pocan S | 2004 | Turk J Gastroentrero12004，15，： | 1 |
| 14 | Effects of a long-acting somatosta- tin analogue, lanreotide, on bile duct ligation-induced liver fibrosis in rats显示文摘 | Tahan G Eren F Tarcin O | 2010 | Turk J Gastroentero12010，21，3： | 1 |
| 15 | Time course of collagen peak in bile duct-ligated rats 显示文摘 | Tarcin O Basaranoglu M Tahan V | 2011 | BMC Gastroen- terol2011，11，： | 1 |
| 16 | Association of metabolic syndrome parameters with TT3 and FT3/FT4 ratio in obese Turkish population显示文摘 | Tarcin O Abanonu GB Yazici D | 2012 | Metab Syndr Relat Disord2012，10，2： | 1 |
| 17 | Insulin resistance,adipocyte biology,and thiazolidinediones:a review显示文摘 | Tarcin O Bajaj M Akalin S | 2007 | Metabolic Syndrone and Related Disorders2007，5，2： | 1 |
| 18 | Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects显示文摘 | Tarcin O Yavuz DG Ozben B | | 0，，10： | 1 |
| 19 | A custimulation of the Neiguan point during gastroscopy:its effects on nausea and retching显示文摘 | Tarcin O Pocan S Kesin O | 2004 | Turk J Gastroenterol2004，15，4： | 1 |
| 20 | In vivo inefficiency of pentoxifylline and interon-alpha on hepatic fibrosis in biliary-obstruc-ted rats:assessment by tissue collagen content and prolidase activity显示文摘 | Avsar K Demirturk L | 2003 | J Gastroenterol Hepatol2003，18，： | 1 |
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