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您的检索式：作者名="Tangliang LI"
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| 1 | DNA Damage Response in Hematopoietic Stem Cell Ageing显示文摘Maintenance of tissue-specific stem cells is vital for organ homeostasis and organismal longevity.Hematopoietic stem cells(HSCs) are the most primitive cell type in the hematopoietic system.They divide asymmetrically and give rise to daughter cells with HSC identity(selfrenewal) and progenitor progenies(differentiation),which further proliferate and differentiate into full hematopoietic lineages.Mammalian ageing process is accompanied with abnormalities in the HSC self-renewal and differentiation.Transcriptional changes and epigenetic modulations have been implicated as the key regulators in HSC ageing process.The DNA damage response(DDR)in the cells involves an orchestrated signaling pathway,consisting of cell cycle regulation,cell death and senescence,transcriptional regulation,as well as chromatin remodeling.Recent studies employing DNA repair-deficient mouse models indicate that DDR could intrinsically and extrinsically regulate HSC maintenance and play important roles in tissue homeostasis of the hematopoietic system.In this review,we summarize the current understanding of how the DDR determines the HSC fates and finally contributes to organismal ageing. | Tangliang Li Zhong-Wei Zhou Zhenyu Ju Zhao-Qi Wang | 2016 | Genomics, Proteomics & Bioinformatics2016，14，3： | 1 |
| 2 | Sirt6通过表观遗传调控Wnt信号通路控制造血干细胞的稳态显示文摘Wnt信号通路对造血干细胞稳态的维持是至关重要的,但Wnt信号在造血干细胞中的表观遗传调控规律仍然是未知的。 | 汪虎 Daojun Diao Zhencan Shi Xudong Zhu Yawei Gao Shaorong Gao Xiaoyu Liu You Wu K.Lenhard Rudolph Guanghui Liu Tangliang Li 鞠振宇 | 2017 | 科学新闻2017，19，4： | 0 |
| 3 | Spatial expression of the nonsense-mediated mRNA decay factors UPF3A and UPF3B among mouse tissues显示文摘Nonsense-mediated mRNA decay(NMD)is a highly conserved post-transcriptional gene regulatory mechanism in eukaryotes(Lykke-Andersen and Jensen,2015;Kurosaki et al.,2019;Yi et al.,2021;Karousis and Muhlemann,2022;Mailliot et al.,2022). | Xin MA Yan LI Chengyan CHEN Yanmin SHEN Hua WANG Tangliang LI | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，11： | 0 |
| 4 | Current understanding of the mechanisms of stem cell aging显示文摘Remarkable progress has taken place in the research of stem cells during the past 30 years.General perceptions,experimental and clinical evidences pinpoint the fact that functional decline of tissue often coincides with aging-related diseases.Stem cell aging plays a fundamental role in the dysregulation of tissue function,maintenance,and repairing.This review specifically focuses on the current findings and emerging concepts of hematopoietic stem cell aging and its mechanisms. | ZHU XuDong LI TangLiang JU ZhenYu | 2016 | Science Foundation in China2016，24，3： | 0 |
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