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| 1 | Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein显示文摘AIM To compare the therapeutic effect andsignificances of multimodality treatment forhepatocellular carcinoma (HCC) with tumorthrombi in portal vein (PVTT).METHODS HCC patients (n = 147) with tumortrombi in the main portal vein or the first branchof portal vein were divided into four groups bythe several therapeutic methods. There wereconservative treatment group in 18 out ofpatients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAl)group in 18 patients (group B), in whompostoberative chemoembolization was doneperiodically; group of removal of HCC with PVTTin 79 (group C) and group of transcatheterhepatic arterial chemoembolization (TACE) orHAl and/or portal vein infusion (PVI) afteroperation in 32 (group D).RESULTS The median survival period was 12months in our series and the 1-, 3-, and 5-yearsurvival rates were 44.3%, 24.5% and 15.2%,respectively. The median survival times were 2,5, 12 and 16 months in group A, B, C and D,respectively. The 1-, 3- and 5-year survival rateswere 5.6%, 0% and 0% in group A; 22.2%,5.6% and 0% in group B; 53.9%, 26.9% and16.6% in group C; 79.3%, 38.9% and 26.8% ingroup D, respectively. Significant differenceappeared in the survival rates among the groups(P<0.05).CONCLUSION Hepatic resection with removalof tumor thrombi and HCC should increase thecurative effects and be encouraged for theprolongation of life span and quality of life forHCC patients with PVTT, whereas the besttherapeutic method for HCC with PVTT is withregional hepatic chemotherapy orchemoemblization after hepatic resection withremoval of tumor thrombi. | Jia Fan Zhi Quan Wu Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 80 |
| 2 | Optimization design and analysis of Si-^(63)Ni betavoltaic battery显示文摘Among the various micro-powers being investigated, betavoltaic batteries are very attractive for numerous applications because of their advantages of high energy density, long life, strong anti-interference, and so on. Based on the basic principle of the betavoltaic effect, the current paper adopted the Monte Carlo N-Particle code to simulate the transport processes of β particles in semiconductor materials and to establish the calculation formulas for nuclear radiation-generated current, open circuit voltage, and so on. By discussing the effect of minority carrier diffusion length, doping concentration, and junction depth on the property of batteries, the present work concluded that the best parameters for batteries are the use of silicon and the radioisotope Ni-63, i.e., Ni-63 with a mass thickness of 1 mg/cm2, Na=1×1019 cm-3, Nd=3.16×1016 cm-3, junction area of 1 cm2, junction depth of 0.3 μm, and so on. Under these parameters the short-circuit current, open circuit voltage, output power, and conversion efficiency are 573.3 nA, 0.253 V, 99.85 nW, and 4.94%, respectively. Such parameters are valuable for micro-power fields, such as micro-electromechanical systems and pacemakers, among others. | TANG XiaoBin DING Ding LIU YunPeng CHEN Da | 2012 | Science China(Technological Sciences)2012，55，4： | 11 |
| 3 | Human organoids in basic research and clinical applications显示文摘Organoids are three-dimensional(3D)miniature structures cultured in vitro produced from either human pluripotent stem cells(hPSCs)or adult stem cells(AdSCs)derived from healthy individuals or patients that recapitulate the cellular heterogeneity,structure,and functions of human organs.The advent of human 3D organoid systems is now possible to allow remarkably detailed observation of stem cell morphogens,maintenance and differentiation resemble primary tissues,enhancing the potential to study both human physiology and developmental stage.As they are similar to their original organs and carry human genetic information,organoids derived from patient hold great promise for biomedical research and preclinical drug testing and is currently used for personalized,regenerative medicine,gene repair and transplantation therapy.In recent decades,researchers have succeeded in generating various types of organoids mimicking in vivo organs.Herein,we provide an update on current in vitro differentiation technologies of brain,retinal,kidney,liver,lung,gastrointestinal,cardiac,vascularized and multi-lineage organoids,discuss the differences between PSC-and AdSC-derived organoids,summarize the potential applications of stem cell-derived organoids systems in the laboratory and clinic,and outline the current challenges for the application of organoids,which would deepen the understanding of mechanisms of human development and enhance further utility of organoids in basic research and clinical studies. | Xiao-Yan Tang Shanshan Wu Da Wang Chu Chu Yuan Hong Mengdan Tao Hao Hu Min Xu Xing Guo Yan Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 10 |
| 4 | Optimization design of GaN betavoltaic microbattery显示文摘Betavoltaic radioisotope microbatteries have gradually become the research direction of micro-power sources because of their several advantages,including small scale,stable output performance,long service life,high energy density,strong anti-jamming capability,and so on.Based on the theory of semiconductor physics,the current paper presented a design scheme of isotope microbattery with wide-gap semiconductor material GaN and isotope 147Pm.In consideration of the isotope's self-absorption effect,the current paper studied and analyzed the optimization thickness of semiconductor and isotope source,junction depth,depletion region thickness,doping concentration,and the generation and collection of electron hole pairs with simulation of transport process of beta particles in semiconductor material using Monte Carlo simulation program MCNP.In the proposed design scheme,for a single decay,an average energy of 28.2 keV was deposited in the GaN,and the short circuit current density,open circuit voltage,and efficiency of a single device were 1.636 μA/cm2,3.16 V,and 13.4%,respectively. | TANG XiaoBin LIU YunPeng DING Ding CHEN Da | 2012 | Science China(Technological Sciences)2012，55，3： | 5 |
| 5 | An Outbreak of Multidrug-Resistant Tuberculosis in a Secondary School --Hubei Province, 2019显示文摘What is already known about this topic?Multidrug-resistant tuberculosis(MDR-TB)is a type of tuberculosis with resistance to common treatments such as isoniazid and rifampicin.MDR-TB is a major global health challenge and needs to be controlled tightly through prevention measures,early diagnosis,and full treatment and management.What is added by this report?This outbreak was the first MDR-TB related public health emergency in Hubei Province.In total,five MDR-TB cases and nine clinically diagnosed cases were identified within one class in a secondary school.Students and teachers from other classes were monitored,but no other cases were found.What are the implications for public health practice?The implementation of TB prevention and control measures in schools is important to increase knowledge on TB and to raise awareness on protecting personal wellbeing.The Automatic Early Warning Information System alerted the local health department and allowed for a timely response to prevent further disease spread. | Mengxian Zhang Tang Wang Shuangyi Hou Jianjun Ye Liping Zhou Zhong Zhang Zhiqiang Deng Qin Da Guoming Li Shiyue Li | 2019 | China CDC weekly2019，1，5： | 5 |
| 6 | An AGAMOUS-like factor is associated with the origin of two domesticated varieties in Cymbidium sinense (Orchidaceae)显示文摘Cymbidium has been artificially domesticated for centuries in Asia,which produced numerous cultivated varieties.Flowers with stamenoid tepals or those with multiple tepals have been found in different species of Cymbidium;however,the molecular basis controlling the formation of these phenotypes is still largely unknown.Previous work demonstrated that AGAMOUS/AG lineage MADS genes function in floral meristem determinacy as well as in reproductive organs development in both dicots and monocots,indicating a possible relationship with the origin of two flower varieties in Cymbidium.Here,we characterized and analyzed two AG lineage paralogues,CsAG1 and CsAG2,from Cymbidium sinense,both of which were highly expressed in the gynostemium column of a standard C.sinense.Interestingly,we detected ectopic expression of CsAG1 rather than CsAG2 in all floral organs of a stamenoid-tepal variety and significant down-regulation of CsAG1 in a variety with multiple tepals.Over-expression of CsAG1 in wild type Arabidopsis resulted in petal-to-stamen homeotic conversion,suggesting a conserved C-function of CsAG1 in the development of Cymbidium flower.Altogether,our results supported a hypothesis that disruption of a single AG-like factor would be associated with the formation of two domesticated varieties in C.sinense. | Shihao Su Xiaoyu Shao Changfa Zhu Jiayin Xu Yuhuan Tang Da Luo Xia Huang | 2018 | Horticulture Research2018，5，1： | 4 |
| 7 | Development of Chinese hybrid radiation adult phantoms and their application to external dosimetry显示文摘This paper presents the construction of Chinese hybrid radiation adult phantoms,which are compatible with anatomical parameters for the Chinese reference population.The phantoms were designed using polygonal mesh surface,which makes the phantom more flexible and realistic than previous generations.Voxelization of hybrid phantoms was performed to adopt Monte Carlo methods.External dose coefficients were calculated by Geant4 and compared to the ICRP reference phantom.The results show that the organ dose is different from ICRP116 with the low energy photons,which can be ascribed to the anatomy and topology difference of each organ.The effective dose of CHRAP is 19%higher than ICRP 116 in the energy range from10 to 100 keV and is almost the same in the energy range from 100 keV to 10 MeV.These phantoms can be used as the basic phantom to adjust the posture or organ volume to estimate dosimetry in medical and space explorations. | GENG ChangRan TANG XiaoBin HOU XiaoXiao SHU DiYun CHEN Da | 2014 | Science China(Technological Sciences)2014，57，4： | 4 |
| 8 | CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study显示文摘Objective To understand the relationships between CDH13(T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight(HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels(per T: Coef =-0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels(per A: Coef =-0.221, P = 0.001) and HMW adiponectin levels(per A: Coef =-0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke(GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction(α = 0.025). There was an interaction between rs7193788 and diabetes(P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke(OR = 2.64, 95% CI: 1.58-4.40, P < 0.001). Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke. | CHEN Li SUN Ke Xin JUAN Juan FANG Kai LIU Kuo WANG Xue Yin WANG Ling YANG Chao LIU Xiao Qiang LI Jing TANG Xun WU Yi Qun QIN Xue Ying WU Tao CHEN Da Fang HU Yong Hua | 2017 | Biomedical and Environmental Sciences2017，30，1： | 4 |
| 9 | Inhibiting wear particles-induced osteolysis with doxycycline显示文摘瞄准:在 osteoclastogenesis,成熟骨破折命运和功能上学习 doxycycline (纪录影片) 的效果,并且为对待在联合关节造形术以后的无菌的松开和骨质溶解提供一些基础,穿导致粒子的 osteoeolysis。方法:骨破折与 NF-kappaB ligand 和刺激因素的巨噬细胞殖民地的受体使活跃之物从老鼠骨髓单核白血球被产生。在 5, 10, 15,和 20 mug/mL 的集中的纪录影片分别地被加到媒介。七天以后,骨破折通过染色的酒石酸盐抵抗的酸性磷酸酯酶(陷井) 被决定。成熟骨破折从新生的兔子被孤立并且为在 24 井盘子中或在骨头片上的 3 d 有教养。在 5, 10, 15,和 20 mug/mL 的集中的纪录影片分别地被加到媒介。在陷井染色以后,骨破折被数,骨头片上的再吞被确定,并且区域在 toluidine 并且 Mayer-hematoxylin 染色以后是计算的。Polymethyl methacrylate (PMMA ) 或超离频分子量聚乙烯(UHMWPE ) 粒子在 C57BL/J6 老鼠的 calvariae 上被植入。在 2 和 10 mg/kg/d 的剂量,纪录影片分别地为 7 d intraperitoneally 被给。七天以后, calvariae 为病理学的分析被移开并且处理。结果:纪录影片处理有效地禁止了在试管内 osteoclastogenesis,影响了成熟骨破折的命运,并且禁止了成熟骨破折,引起骨吸收。在活体内数据显示那部纪录影片强烈禁止了 PMMA 或导致 UHMWPE 的骨质溶解和 osteoclastogenesis。结论:纪录影片能有效地禁止 osteoclastogenesis 并且影响成熟骨破折命运并且压制骨质溶解和 osteoclastogenesis 导致的 wear 粒子。纪录影片可能在处理或预防是有用的穿导致粒子的骨质溶解并且在骨破折产生和成熟骨破折命运和功能上的为它的效果的无菌的松开。 | Chao ZHANG Ting-ting TANG Wei-ping REN Xiao-ling ZHANG Ke-rong DA | 2007 | Acta Pharmacologica Sinica2007，28，10： | 3 |
| 10 | FAILURE ANALYSIS OF PEELING PROCESS FOR TITANIUM ANODES COATINGS显示文摘FAILUREANALYSISOFPEELINGPROCESSFORTITANIUMANODESCOATINGSTangDian;ChenShiren(InstituteforMaterialsResearch,FuzhouUniversity,Fu... | Tang, DA Chen, SR Lin, XA Cui, X Yan, Q | 1995 | 中国有色金属学会会刊:英文版1995，5，4： | 3 |
| 11 | Evaluation of hyperbaric oxygen treatment of neuropsychiatric disorders following traumatic brain injury显示文摘Background Improvement of clinical symptoms following hyperbaric oxygen (HBO) treatment of neuropsychiatric disorders arising from traumatic brain injury was proved by our previous study. This study was aim to obtain the evidence of other changes. Methods Three hundred and ten patients with neuropsychiatric disorders arising from traumatic brain injury were treated twice with hyperbaric oxygen. Cerebral single photon emissions computed tomography (SPECT) images and computed tomography scans (CT) before and after hyperbaric oxygen treatment, were compared. Results Before treatment, the proportion of abnormal cerebral changes detected by SPECT was 81.3% but only 15.2% by CT. After HBO treatment, 70.3% of SPECT scans showed no abnormalities and these patients were clinically improved. Treatment improved regional cerebral blood flow. Conclusion SPECT was much more sensitive than CT in the diagnosis of neuropsychiatric disorders following hyperbaric oxygen treatment of neuropsychiatric disorders arising from traumatic brain injury. | SHI Xiao-yan TANG Zhong-quan SUN Da HE Xiao-jun | 2006 | Chinese Medical Journal2006，，23： | 3 |
| 12 | A Non-Stop Double Buffering Mechanism for Dataflow Architecture显示文摘两倍缓冲是有效机制隐藏在在薄片上和离开薄片记忆之间的数据转移的潜伏。在 dataflow 建筑学,因为 dataflow 加速器的重复充满并且排干,然而,交换二在许多瓦减少的执行期间缓冲性能。在这个工作,我们为 dataflow 建筑学建议连续双的缓冲机制。没有停止通过在 dataflow 建筑学优化控制逻辑处理元素的执行,建议不停的机制把瓦分到处理元素数组。而且,我们建议一个工作流节目与连续双的缓冲机制合作。在控制逻辑上并且在工作流节目上的优化以后,充满并且排干数组需要越过属于一样的 dataflow 图的所有瓦的执行被做仅仅一次。试验性的结果证明没有优化,为 dataflow 建筑学的建议双缓冲机制在那上完成 16.2% 平均效率改进。 | Xu Tan Xiao-Wei Shen Xiao-Chun Ye Da Wang Dong-Rui Fan Lunkai Zhang Wen-Ming Li Zhi-Min Zhang Zhi-Min Tang | 2018 | Journal of Computer Science & Technology2018，33，1： | 3 |
| 13 | Observation of biophoton emission from plants in the process of defense response显示文摘Biophoton emission from germinating soybean under adverse circumstance has been observed by high sensitive imaging system based on ICCD detector. It is found that the intensity of biophoton emission from the injured position of the cotyledon is enhanced obviously compared with the intact position. In addition, a strong biophoton emission has been detected at the tip | Da Xing Shici Tan Yonghong Tang Yonghong He Dehong Li | 1999 | Chinese Science Bulletin1999，44，23： | 3 |
| 14 | High-throughput screening and machine learning for the efficient growth of high-quality single-wall carbon nanotubes显示文摘It has been a great challenge to optimize the growth conditions toward structure-controlled growth of single-wall carbon nanotubes(SWCNTs).Here,a high-throughput method combined with machine learning is reported that efficiently screens the growth conditions for the synthesis of high-quality SWCNTs.Patterned cobalt(Co)nanoparticles were deposited on a numerically marked silicon wafer as catalysts,and parameters of temperature,reduction time and carbon precursor were optimized.The crystallinity of the SWCNTs was characterized by Raman spectroscopy where the featured G/D peak intensity(IG/ID)was extracted automatically and mapped to the growth parameters to build a database.1,280 data were collected to train machine learning models.Random forest regression(RFR)showed high precision in predicting the growth conditions for high-quality SWCNTs,as validated by further chemical vapor deposition(CVD)growth.This method shows great potential in structure-controlled growth of SWCNTs. | Zhong-Hai Ji Lili Zhang Dai-Ming Tang Chien-Ming Chen Torbjörn EMNordling Zheng-De Zhang Cui-Lan Ren Bo Da Xin Li Shu-Yu Guo Chang Liu Hui-Ming Cheng | 2021 | Nano Research2021，14，12： | 3 |
| 15 | Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway显示文摘 | Yi Mao Liang Da Hong Tang Jiali Yang Yinrui Lei Pierre Tiollais Tsaiping Li Mujun Zhao | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 2 |
| 16 | Theoretical study on boiling heat transfer in the Xi'an pulsed reactor显示文摘Boiling heat transfer condition has significance for pool-type research reactors cooled by natural circulation.It has important effect on the fuel element safety of reactor.On the basis of heat transfer characteristics of the Xi'an pulsed reactor(XAPR),fuel conduction,single-phase convection and boiling heat transfer,and void fraction models of the core are constructed.To validate the correctness of the physical models presented in the paper,numerical calculation based on a subchannel analysis method of XAPR is carried out,and the temperature fields are measured in some reactor coolant channels.The comparison between the calculated and experimental results verifies the effectiveness of the models.These physical models are used to calculate the thermal-hydraulic parameters of XAPR at the rated power(for XAPR the rated power is 2.0 MW in steady-state operation).The results indicate that subcooled boiling occurs in the XAPR core but it exhibits a subcooling degree which is considerably higher than that of saturation boiling.Subcooled boiling improves the efficiency of heat transfer between the fuel element surface and coolant,as well as effectively protects fuel elements.This research is also a beneficial reference in thermal-hydraulic analysis for other natural circulation reactors. | CHEN LiXin TANG XiaoBin JIANG XinBiao CHEN Da ZHAO ZhuMin | 2013 | Science China(Technological Sciences)2013，56，1： | 2 |
| 17 | Ultrastructural observation of liver tissue ablation induced by high-intensity focused ultrasound显示文摘UltrastructuralobservationoflivertissueablationinducedbyhighintensityfocusedultrasoundCHENGShuQun1,ZHOUXinDa1,TANGZhaoYo... | CHENG Shu Qun 1, ZHOU Xin Da 1, TANG Zhao You 1, YU Yao 1, BAO Su Su 2 and QIAN De Chu 2 | 1997 | World Journal of Gastroenterology1997，3，3： | 2 |
| 18 | Theoretical investigation on Raman induced Kerr effect spectroscopy in nonlinear confocal microscopy显示文摘The imaging theory of Raman induced Kerr effect spectroscopy (RIKES) in nonlinear confocal microscopy is presented in this paper. Three-dimensional point spread function (3D-PSF) of RIKES nonlinear confocal microscopy in isotropic media is derived with Fourier imaging theory and RIKES theory. The impact of nonlinear property of RIKES on the spatial resolution and imaging properties of confocal microscopy have been analyzed in detail. It is proved that RIKES nonlinear confocal microscopy can simultaneously provide more information than two-photon confocal microscopy concerning molecular vibration mode, vibration orientation and optically induced molecular reorientation, etc. It is shown that RIKES nonlinear confocal microscopy significantly enhances the spatial resolution and imaging quality of confocal microscopy and achieves much higher resolution than that of two-photon confocal microscopy. | GUO LiNa TANG ZhiLie XING Da | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，7： | 2 |
| 19 | Stereoselective binding of mexiletine and ketoprofen enantiomers with human serum albumin domains显示文摘瞄准: 与人的浆液白朊(HSA ) 的不同 recombinant 领域调查 mexiletine 或 ketoprofen enantiomers 的 stereoselective 绑定。 | Da SHI Yin-xiu JIN Yi-hong TANG Hai-hong HUi Si-yun XU Lu-shan YU Hui-di JIANG Su ZENG | 2012 | Acta Pharmacologica Sinica2012，33，5： | 2 |
| 20 | Hepatitis B virus X protein sensitizes cells to starvation‐induced autophagy via up‐regulation of beclin 1 expression显示文摘 | Hong Tang Liang Da Yi Mao Ying Li Dong Li Zhenhua Xu Feng Li Yifei Wang Pierre Tiollais Tsaiping Li Mujun Zhao | 2008 | Hepatology2008，，1： | 2 |
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