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| 1 | Influence of hepatitis viruses on clinico-pathological profiles and long-term outcome in patients undergoing surgery for hepatocellular carcinoma显示文摘BACKGROUND: The global risk of hepatocellular carcinoma(HCC) is largely due to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In recent years, however, an increased prevalence of non-viral HCC has been noted. The clinical impact of the presence/absence of viral infections in HCC remains controversial. The present study aimed to assess the effect of hepatitis viruses on demographics, clinical and pathological features and long-term outcome in a large cohort of Romanian patients who underwent surgery for HCC. METHODS: The study included 404 patients with HCC who had undergone resection, transplantation or radiofrequency ablation at a single institution between 2001 and 2010. The patients were divided into four groups: 85 patients with hepatitis B virus infection (HBV group), 164 patients with hepatitis C virus infection (HCV group), 39 patients with hepatitis B and C virus co-infection (HBCV group), and 116 patients without viral infection (non-BC group). RESULTS: The patients of both HBV (56.0±11.3 years) and HBCV groups (56.0±9.9 years) were significantly younger than those of the HCV (61.0±8.5 years, P=0.001) and non-BC groups(61.0±13.0 years, P=0.002). Interestingly, the prevalence of liver cirrhosis was significantly lower in the non-BC group (47%)than in any other subsets (72%-90%, P<0.002). Furthermore, the non-BC patients were more advanced according to the Barcelona Clinic Liver Cancer stages than the patients of the HCV or HBCV groups (P<0.020); accordingly, they were more frequently assessed beyond the Milan criteria than any other groups (P=0.001). No significant differences in the disease-free or overall survival rates were observed among these groups. CONCLUSIONS: Patients with non-viral HCC are diagnosed at advanced ages and stages, a situation plausibly due to the poor effectiveness of cancer surveillance in community practice. The presence of viral infections does not appear to impair the longterm prognosis after surgical treatment in patients with HCC; however, there is a trend for worse disease-free survival rates in HBCV patients, though statistical significance was not reached. | Anna-Maria Tanase Traian Dumitrascu Simona Dima Razvan Grigorie Agnes Marchio Pascal Pineau Irinel Popescu | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 7 |
| 2 | Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics显示文摘Pancreatic cancer is one of the most aggressive and lethal malignancies. Despite remarkable progress in understanding pancreatic carcinogenesis at the molecular level, as well as progress in new therapeutic approaches, pancreatic cancer remains a disease with a dismal prognosis. Among the mechanisms responsible for drug resistance, the most relevant are changes in individual genes or signaling pathways and the presence of highly resistant cancer stem cells(CSCs). In pancreatic cancer, CSCs represent 0.2%-0.8% of pancreatic cancer cells and are considered to be responsible for tumor growth, invasion, metastasis and recurrence. CSCs have been extensively studied as of late to identify specific surface markers to ensure reliable sorting and for signaling pathways identified to play a pivotal role in CSC self-renewal. Involvement of CSCs in pancreatic cancer pathogenesis has also highlighted these cells as the preferential targets for therapy. The present review is an update of the results in two main fields of research in pancreatic cancer, pathogenesis and therapy, focused on the narrow perspective of CSCs. | Cristiana Pistol Tanase Ana Iulia Neagu Laura Georgiana Necula Cristina Mambet Ana-Maria Enciu Bogdan Calenic Maria Linda Cruceru Radu Albulescu | 2014 | World Journal of Gastroenterology2014，20，31： | 4 |
| 3 | The impact of having an oxygen-rich microporous surface in carbon electrodes for high-power aqueous supercapacitors显示文摘The growth of electrical transportation is crucially important to mitigate rising climate change concerns regarding materials supply.Supercapacitors are high-power devices,particularly suitable for public transportation since they can easily store breaking energy due to their high-rate charging ability.Additionally,they can function with two carbon electrodes,which is an advantage due to the abundance of carbon in biomass and other waste materials(i.e.,plastic waste).Newly developed supercapacitive nanocarbons display extremely narrow micropores(<0.8 nm),as it increases drastically the capacitance in aqueous electrolytes.Here,we present a strategy to produce low-cost flexible microporous electrodes with extremely high power density(>100 kW kg^(-1)),using fourty times less activating agent than traditionnal chemically activated carbons.We also demonstrate that the affinity between the carbon and the electrolyte is of paramount importance to maintain rapid ionic diffusion in narrow micropores.Finally,this facile synthesis method shows that low-cost and bio-based free-standing electrode materials with reliable supercapacitive performances can be used in electrochemistry. | Servann Herou Maria Crespo Ribadeneyr Philipp Schlee Hui Luo Liviu Cristian Tanase Christine Roβberg Magdalena Titirici | 2021 | Journal of Energy Chemistry2021，30，2： | 2 |
| 4 | An exploratory study ofinflammatory cytokines as prognostic biomarkers in patients withductal pancreatic adenocarcinoma 显示文摘 | Dima SO Tanase C Albulescu R | 2012 | Pancreas2012，41，7： | 1 |
| 5 | Test for the electro static crop spraying as a method of treatment with vctra low volume, the modern problems of electrostatics with applications in environment protection显示文摘 | Cramariuc R Nisiparu L Tanase G | 1998 | NATO ASI Seriea1998，118，： | 1 |
| 6 | Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis 显示文摘 | Bekersky I Fitzsimmons W Tanase A | 2001 | J Am Acad Dematol2001，44，1： | 1 |
| 7 | Design of Novel Malonates as Internal Donors for MgC12-Supported TiCI4 Type Polypropylene Catalysts and Their Mechanistic Aspects: Part l显示文摘 | Tanase S Katayama K Yabunouchi N | 2007 | JMolCatalA: Chem2007，273，12： | 1 |
| 8 | PLA/chitosan/keratin corn-posites for biomedical applications显示文摘 | Tanase C E Spiridon I | 2014 | Mat Sci Eng: C -Mater2014，40，： | 1 |
| 9 | Hydrodynamic size-based separation and characterization of protein aggregates from total cell lysates显示文摘 | TANASE M ZOLLA V CLEMENT C C | 2015 | Nat Protoc2015，10，1： | 1 |
| 10 | Caveolin-1 overexpression correlates with tumour progression markers in pancreatic ductal adenocarcinoma显示文摘 | Tanase CP Dima S Mihai M | 2009 | J Mol Histol2009，40，1： | 1 |
| 11 | Con- siderations on detailed analysis and particle growth in high impact polypropylene particles显示文摘 | Katayama Kiyokazu Tanase Shojiro Ishihara Nobuhide | 2011 | Journal of Applied Polymer Science2011，122，1： | 1 |
| 12 | Electrode properties and Lithiation/Delithiation reactions of Ag-Sb-Sn nanocomposite anodes in Li-ion batteries 显示文摘 | YIN J T WADA M TANASE S | 2004 | Journal of the Electrochemical Society2004，151，6： | 1 |
| 13 | A case of early-stage ovarian carcinoid tumor metastasized to the liver显示文摘 | Kanayama S Yamada Y Tanase Y | 2012 | Case Rep Ob- stet Gynecol2012，10，： | 1 |
| 14 | Patented biomark- er panels in early detection of cancer 显示文摘 | Neagu M Constantin C Tanase C | 2011 | Recent Patents on Biomarkers2011，1，1： | 1 |
| 15 | Life expectancy is reduced in differentiated thyroid cancer patients ≥45 years old with extensive local tumor invasion, lateral lymph node, or distant metastases at diagnosis and normal in all other DTC patients 显示文摘 | Verburg FA Mader U Tanase K | 2012 | J Clin Endocrinol Metab2012，98，1： | 1 |
| 16 | Comparison of plasma LH, pragestrone,testosterone and estradiol concentrations in male and female chickens(Gallus domesticus) from 28 to 141 days of age显示文摘 | Tanabe Y Nakamura T Tanase H | 1981 | Endocrinology1981，28，： | 1 |
| 17 | Size effect on crystal structures of BaTiO3 Nanoparticles prepared by a sol-gel method显示文摘 | Kobayashi Y Nishikata A Tanase T | 2004 | J Sol-gel Sci Tech2004，29，1： | 1 |
| 18 | Some properties and cutting performance of polycrystalline cubic boron nitride with no additives显示文摘 | T. Ohashi K. Yamamoto Y. Hamada T. Tanase | 1998 | International Journal of Refractory Metals and Hard Materials1998，，4： | 1 |
| 19 | Plasma Clearance of intravenously injected aspartate aminotransferase isozymes:evidence for preferential uptake by sinusoidal liver cells显示文摘 | Kanimoto Y Horiuchi S Tanase S | 1985 | Hepatology1985，5，3： | 1 |
| 20 | circularly exchange-biased ferromagnetic disks显示文摘 | Tanase M Petford-Long A Magnetization reversal in K Heinonen O | 2009 | Physical Review B2009，79，1： | 1 |
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