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| 1 | 2型糖尿病消瘦患者预后差显示文摘由于常将体质指数(BMI)〈18 kg/m^2患者排除在外,以往研究中关于BMI与糖尿病死亡率之间的关系不一定能全面反映整个人群的情况。为此,来自日本东京大学公共卫生学院的Hirohito Sone教授及其团队进行了一项研究,调查2型糖尿病患者BMI与死亡率之间的关系。该研究结果在线发表于2014年9月9日的The Journal of Clinical Endocrinology&Metabolism杂志。 | Tanaka S Iimuro S | 2014 | 中国全科医学2014，17，32： | 13 |
| 2 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 3 | Presentation,management,and outcome of newly diagnosed glioblastoma in elderly patients显示文摘OBJECT: Optimum management for elderly patients with newly diagnosed glioblastoma(GBM) in the temozolomide(TMZ) era is not well defined.The object of this study was to clarify outcomes in this population.METHODS: The authors retrospectively reviewed 105 consecutive cases involving elderly patients(age ≥ 65 years) with newly diagnosed GBM who were treated at the Mayo Clinic between 2003 and 2008.RESULTS: The patients' median age was 74 years(range 66-87 years),and the median Karnofsky Performance Status(KPS) score was 80(range 40-90).Half of the patients underwent biopsy and half underwent resection.Patients with deep-seated lesions(19 patients [18%]) or multifocal lesions(34 patients [32%]) were more likely to have biopsy than resection(p = 0.0001 and 0.0009,respectively).New persistent neurological deficits developed in 7 patients(6.7%).Postoperative hemorrhage occurred in 6 patients(5.7%),all of whom underwent biopsy.Complete follow-up data regarding adjuvant treatment was available in 84 patients.Forty-one(49%) were treated with chemotherapy(mostly TMZ) and radiation therapy(RT),and 23(27%) with RT alone.Nineteen(23%) received only palliative care after surgery(more common with biopsy,p = 0.03).Chemotherapy complications occurred in 28.6%(Grade 3 or 4 hematological complications in 11.9%).The median values for progression-free survival(PFS) and overall survival(OS) were 3.5 and 5.5 months.In a multivariate analysis,younger age(p = 0.03,risk ratio [RR] 0.34,95% CI 0.13-0.89),single lesion(p = 0.02,RR 0.51,95% CI 0.30-0.89),resection(p = 0.04,RR 0.54,95% CI 0.31-0.94),and adjuvant treatment(p = 0.0001,RR 0.24,95% CI 0.11-0.49) were associated with better OS.Only adjuvant treatment was significantly associated with prolonged PFS(p = 0.0007,RR 0.27,95% CI 0.13-0.57).With combined therapy with resection,RT,and chemotherapy,the median PFS and OS were 8 and 12.5 months,respectively.CONCLUSIONS: The prognosis for GBM worsens with increasing age in elderly patients.With important risks,resection and adjuvant treatment are associated with prolonged survival.Although selection bias cannot be excluded in this retrospective study,advanced age alone should not necessarily preclude optimal resection followed by adjuvant radiochemotherapy. | Tanaka S Meyer FB Buckner JC Uhm JH Yan ES Parney IF | 2013 | 中国神经肿瘤杂志2013，11，1： | 4 |
| 4 | Investigations of the subcellular distribution of Bcl-2 on coprotein:residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membrance显示文摘 | Krajewski S Tanaka S Takayama S | 1993 | Cancer Res1993，53，： | 3 |
| 5 | Increased prevalence of intestinal inflammation in patients with liver cirrhosis显示文摘AIM To investigate the pathophysiology of the digestive tract in patients with liver cirrhosis.METHODS In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for intestinalimmunity.RESULTS The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein loss.CONCLUSION These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions. | Saitoh O Sugi K Lojima K Matsumoto H Nakagawa K Kayazawa M Tanaka S Teranishi T Hirata I Katsu Ki K | 1999 | World Journal of Gastroenterology1999，5，5： | 2 |
| 6 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 7 | Inhibition of telomerase increase the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis 显示文摘 | Konodo Y Kondo S Tanaka Y | 1998 | Oncogene1998，16，： | 2 |
| 8 | Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma显示文摘 | Furudoi A Tanaka S Haruma K | | 0，，： | 2 |
| 9 | Cerebral blood flow and oxygen metabolism in patients with progessive dementia and amyotrophic lateral sclerosis显示文摘 | Tanaka M Ichiba T Konda S | 2003 | Neurol Res2003，25，4： | 2 |
| 10 | 100 nm bandwidth flat-gain Raman amplifiers pumped and gain-equalised by 12-wavelength-channel WDM laser diode unit显示文摘 | Y Emori K Tanaka S Namiki | 1999 | Electron Lett1999，35，16： | 2 |
| 11 | Clinicopathologic features and endoscopic treatment of superficially spreading colorectal neoplasms larger than 20 mm 显示文摘 | Tanaka S Haruma K Oka S | 2001 | Gastrointest Endosc2001，54，7： | 1 |
| 12 | Increased expression of cyclooxygenase-2 correlates with resistance to radiation in human prostate adenocarcinoma cells显示文摘 | Anai S Tanaka M Shiverick KT | 2007 | J Urol2007，177，5： | 1 |
| 13 | Regulation of vascular endothelial growth factor(VEGF) -C and VEGF-D expression by the organ microenvironment in human colon carcinoma 显示文摘 | Onogawa S Kitadai Y Tanaka S | 2004 | Euro J Cancer2004，40，10： | 1 |
| 14 | IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion显示文摘 | Tanaka S S Yamaguchi Y L Tsoi B | 2005 | Dev Cell2005，9，6： | 1 |
| 15 | Gastrointestinal manifestations in henoch-schonlein purpura显示文摘 | Yamaba Y Tanaka S Kobayashi T | 2008 | Nippon Rinsho2008，66，7： | 1 |
| 16 | Expression and antitumor effects of TRAIL in human cholangiocarcinoma显示文摘 | Tanaka S Sugimachi K Shirabe K | 2000 | Hcpatology2000，32，3： | 1 |
| 17 | Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma显示文摘 | Ochiurni T Tanaka S Oka S | 2004 | Int J Oncol2004，24，3： | 1 |
| 18 | A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine显示文摘 | TANAKA T TAKAHARA S HATORIM | 2002 | Cancer2002，181，2： | 1 |
| 19 | Effects of thermochemical pretreatment on the anaerobic digestion of waste activated sludge显示文摘 | Tanaka S Kobayashi T Kamiyama K | 1997 | Wat Sci Tech1997，35，8： | 1 |
| 20 | Hypoadiponectinemia inobesity and type 2 diabetes: close association with insulin resistanceand hyperinsulinemia 显示文摘 | Weyer C Funahashi T Tanaka S | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
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