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| 1 | Expression of lipopolysaccharide binding protein and its receptor CD14 in experimental alcoholic liver disease显示文摘AIM: To evaluate the relationship between the expression of lipopolyaaccharides (LPS) binding protein (LBP) and CD14mRNA and the severity of liver injury in alcohol-fed rats.METHODS: Twenty Wietar rats were divided into two groups: ethanol-fed group (group E) and control group (group C). Group E was fed with ethanol( 5-12g. Kg- 1. D-1)and group C received dextrose instead of ethanol. Rats of the two groups were sacrificed at 4 weeks and 8 weeks.Levels of endotoxin and alanine transeminase (ALT) inblood were measured, and liver pathology was observed under light and electronic microscopy. Expressions of LBP and CD14 mRNA in liver tissues were determined by RT-PCR analysis.RESULTS: Plasma endotoxin levels were increased more significantly in group E( 129 ± 21) ng. L- 1 and ( 187 ± 35) ng.L- 1 at 4 and 8 wk than in control rats(48 ± 9) ng. L- 1 and (53±11) ng.L-1, respectively (P< 0.05). Mean values of plasma ALT levels were (1867 ± 250) nkat. L-1 and (2450 ±367) nkat. L- 1 in Group E. The values were increased more dramatically in ethanol-fed rats than in Group C after 4 and 8weeks. In liver section from ethanol-fed rats, there were marked pathological changes (steatosis, cell infiltration and necrosis). In ethanol-fed rats, ethanol administration led to a significant increase in LBP and CD14 mRNA levels compared with the control group ( P< 0.05).CONCLUSION: Ethanol administration led to a significant increase in endotoxin levels in serum and LBP and CD14mRNA expressions in liver tissues. The increase of LBP and CD14 mRNA expression might wake the liver more sensitive to endotoxin and liver injury. | Guo-Qing Zuo~1 Jian-Ping Gong~2 Chang-An Liu~2 Shen-Wei Li~2 Xin-Chuan Wu~2 Kang Yang~2 Yue Li~2 1 Department of Digestive Disease2 Department of General Surgery,Second College of Clinical Medicine &the Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China | 2001 | World Journal of Gastroenterology2001，7，6： | 14 |
| 2 | 肝硬化合并感染诊治进展显示文摘肝硬化是多种慢性肝病的晚期阶段,感染是肝硬化患者最重要的并发症之一,可诱发或加重肝病进展导致肝功能失代偿的发生,是引起肝硬化患者死亡的重要原因之一。本文旨在通过分析肝硬化尤其是失代偿期肝硬化的病理生理变化,深入了解肝硬化合并感染的发生机制,总结诊治经验,从而指导临床正确认识、合理预防、规范诊治。 | 马路园 李星宇 赵彩彦 | 2018 | 临床荟萃2018，33，11： | 1 |
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