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| 1 | Androgen receptor: structure, role in prostate cancer and drug discovery显示文摘Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade by drugs that prevent the production of androgens and/or block the action of the AR inhibits prostate cancer growth. However, resistance to these drugs often occurs after 2-3 years as the patients develop castration-resistant prostate cancer (CRPC). In CRPC, a functional AR remains a key regulator. Early studies focused on the functional domains of the AR and its crucial role in the pathology. The elucidation of the structures of the AR DNA binding domain (DBD) and ligand binding domain (LBD) provides a new framework for understanding the functions of this receptor and leads to the development of rational drug design for the treatment of prostate cancer. An overview of androgen receptor structure and activity, its actions in prostate cancer, and how structural information and high-throughput screening have been or can be used for drug discovery are provided herein. | MH Eileen TAN Jun LI H Eric XU Karsten MELCHER Eu-leong YONG | 2015 | Acta Pharmacologica Sinica2015，36，1： | 39 |
| 2 | The Torg-Pavlov ratio in cervical spondylotic myelopathy:a comparative study between patients with cervical spondylotic myelopathy and a nonspondylotic,nonmyelopathic population显示文摘 | Yue WM Tan SB Tan MH | 2001 | Spine2001，26，： | 1 |
| 3 | Treatment of distal internal carotid artery aneurysm with the willis covered stent: a prospective pilot study显示文摘 | Li MH Li YD Tan HQ | 2009 | Radiology2009，253，2： | 1 |
| 4 | Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor- mediated anti-apoptotic effect显示文摘 | Tan WF Zhang X Li MH | 2004 | EurJ Phmacol2004，499，3： | 1 |
| 5 | Gene therapy progress and prospects: the eye显示文摘 | Bainbridge JW Tan MH All RR | 2006 | Gene Ther2006，13，16： | 1 |
| 6 | Percutaneous vertebroplasty for eosinophlic granuloma of the cervical spine in a child显示文摘 | Tan HQ Li MH Wu CG | 2007 | Pediatr Radiol2007，37，10： | 1 |
| 7 | Bisphosphonate-assoeiated atypical fracture of the femur: Spontaneous healing with drug holiday and re- appearance after resumed drug therapy with bilateral simultaneous displaced fraetures-a case report显示文摘 | Puah KL Tan MH | 2011 | Acta Orthop2011，82，： | 1 |
| 8 | Pseudolaric acid B inhibits angiogenesis and reduces hypoxia - inducible factor Ict by promoting proteasome mediated degradation 显示文摘 | Li MH Miao ZH Tan WF | 2004 | Clin Cancer Res2004，10，： | 1 |
| 9 | Effects of thiazolidinediones on the triad of type 2 diabetes mellitus,insulin resistance and cardiovascular disease显示文摘 | Chan JYC Ilag L Tan MH | 2007 | Diabetes Res Clin Pract2007，78，： | 1 |
| 10 | Nutritional status and dietary intake of children with acute leukaemia during induction or consolidation chemotherapy显示文摘 | Tan SY Poh BK Nadrah MH | 2013 | J Hum Nutr Diet2013，26，1： | 1 |
| 11 | Idiopathic intracranial hypertension显示文摘 | Wakerley BR Tan MH Ting EY | 2015 | Cephalalgia2015，35，3： | 1 |
| 12 | Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factormediated anti-apoptotic effect显示文摘 | Zhang XW Li MH | 2004 | Eur J Pharmacol2004，499，： | 1 |
| 13 | The effect of central retinal venous pressure in patients with central retinal vein occlusion and a high mean area of nonperfusion显示文摘 | Mc Allister IL Tan MH Smithies LA | 2014 | Ophthalmology2014，121，11： | 1 |
| 14 | The effects of oral antihyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes显示文摘 | Buse JB Tan MH Prince MJ | 2004 | Diabetes Obes Metab2004，6，2： | 1 |
| 15 | Long - term lipid effects of pioglitazone by baseline anti - hyperglycemia medication therapy and statin use from the PROactive experience (PROactive 14) 显示文摘 | Spanheimer R Betteridge J Tan MH | 2009 | The American Journal of Cardiology2009，104，2： | 1 |
| 16 | Characterization of a new primary human pancreatic tumor line显示文摘 | Tan MH Nowak NJ Loor R | 1986 | Cancer Invest1986，4，1： | 1 |
| 17 | Is soluble CD40 ligand a mediator of angiogenesis in patients with coronary artery disease 显示文摘 | Lim HS Tayebjee MH Tan KT | 2008 | ? Thromb Res2008，122，3： | 1 |
| 18 | Nutritional status and dietary in- take of children with acute leukemia during induction or consolidation chemotherapy显示文摘 | Tan SY Poh BK Nadrah MH | 2013 | J Hum Nutr Diet2013，26，1： | 1 |
| 19 | 经皮冠状动脉介入后阻塞性睡眠呼吸暂停与心血管事件的关系显示文摘目前关于阻塞性睡眠呼吸暂停(obstructive sleepapnea,OSA)对冠状动脉疾病患者的预后意义的大型队列研究数据匮乏。该研究假设OSA可预测行经皮冠状动脉介入治疗(percutaneous coronary intervention.PCI)患者未来主要不良心脏和脑血管事件(major adverse cardiac and cerebrovascularevents,MACCE)。方法:睡眠及支架研究是一项前瞻性、多中心注册研究,纳入2011年12月和2014年4月来自5个国家经PCI治疗成功的患者1748例。 | Lee CH Sethi R Li R Ho HH Hein T Jim MH Loo G Koo CY Gao XF Chandra S Yang XX Furlan SF Ge Z Mundhekar A Zhang WW Ucha CH Kharwar RB Chan PF Chen SL Chan MY Richards A Tan HC Ong TH Roldan G Tai BC Drager LF Zhang JJ 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 1 |
| 20 | Insulin binding in human skeletal muscle显示文摘 | Bonen A Hood DA Tan MH | 1984 | Biochim Biophys Acta1984，，801： | 1 |
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