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130篇 您的检索式:作者名="Tan GH"
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1Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma.Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters 2009World Journal of Gastroenterology2009,15,28:11
2Free flap transplantation corn- bined with skin grafting and vacuum sealing drainage for repair of circumferential or sub-circumferential soft-tissue wounds of the lower leg显示文摘Li RG Ren GH Tan XJ 2013Med Sci Monit2013,19,:1
3Active immunotherapy of tumors with a recombinant xenogeneic endoglin as a model antigen显示文摘Tan GH Wei YQ Tian L 2004Eur J Immunol2004,34,7:1
4Thyroid incidentalomas: management ap- proaches to nonpalpable nodules discovered incidentally on thy- roid imaging显示文摘Tan GH Gharib H 1997Ann Intern Med1997,126,3:1
5Free flap transplantation combined with skin grafting and vacuum sealing drainage for repair of circumferential or sub-circumferential soft tissue wounds of the lower leg显示文摘Li RG Ren GH Tan XJ 2013Med Sci Monit2013,19,:1
6Synthesis and characterization of transparent hydrophobic solgel hard coatings显示文摘WU LYL TAN GH ZENG XT 2006Journal of solgel Science and Technology2006,38,1:1
7The controlled differentiation of human neural stem cells into TH2 immunoreactive (ir) neurons in vitro 显示文摘Jin GH Tan XF Tian ML 2005Neurosci Lett2005,386,1:1
8Effects of Brn-4 on the neuronal differen- tiation of neural stem ceils derived from rat midbrain显示文摘Tan XF Qin JB Jin GH 2010Cell Biol Int2010,34,9:1
9Clinical characteristics of triple-negative breast cancer:experience in an Asian developing country显示文摘Tan GH Taib NA Choo WY 2009Asian Pac J Cancer Prev2009,10,3:1
10Saxagliptin added to asubmaximal dose of sulphonylurea improves glycaemic control com-pared with uptitration of sulphonylurea in patients with type 2 dia-betes:a randomised controlled trial显示文摘Chacra AR Tan GH Apanovitch A 2009Clin Pract2009,63,9:1
11Free flap transplantation combined withskin grafting and vacuum sealing drainage for repair of circumferential orsub-circumferential soft-tissue wounds of the lower leg 显示文摘Li RG Ren GH Tan XJ 2013Med SciMonit2013,19,:1
12Safety and effi- cacy of saxagliptin in combination with submaximal sulphony- lurea versus up-titrated sulphonylurea over 76 weeks显示文摘Chacra AR Tan GH Ravichandran S 2011Ia- betes and Vascular Disease Research2011,8,2:1
13Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial 显示文摘Chacra AR Tan GH Apanovitch A 2009Int J Clin Pract2009,63,9:1
14Smoking in China: findings of the 1996 National Prevalence Survey 显示文摘Yang GH Fan LX Tan J 1999JAMA1999,282,13:1
15Multiple-organ effect of normobaric hyperoxia in neonatal rats显示文摘TORBATI D TAN GH SMITH S 2006J Crit Care2006,21,1:1
16Thyroid incidentalomas: management approaches to nonpa|pable nodules discovered incidentally on thyroid imaging显示文摘Tan GH Gharib H 1997Ann Intern Med1997,126,3:1
17Active immunotherapy of tumors with a recombinant xenogeneic endoglin as a model antigen显示文摘TAN GH WEI YQ LING TIAN L 2004Eur J Immunol2004,34,7:1
18Saxagliptinadded to a submaximal dose of sulphonylurea improvesglycaemic control compared with uptitration of sulphony-lurea in patients with type 2 diabetes : A randomised con-trolled trial 显示文摘Chacra AR Tan GH Apanovitch A 2009International Journal of Clinical Practice2009,63,9:1
19Free flap transplantation combined with skin grafting and vacuum sealing drainage for repair of circumferential or sub-circumferential soft-tissue wounds of the lower leg显示文摘Li RG Ren GH Tan X J 2013Med Sci Monit2013,19,:1
20Thyroid incidentalomas: management approaches to non-palpable nodules discovered incidentally on thyroid imaging显示文摘Tan GH Gharib H 1997Ann Intel Med1997,126,3:1
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