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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Identification and character-ization of a novel sericin gene expressed in the anterior middle silkgland of the silkworm Bombyx mori显示文摘 | Takasu Y Yamada H Tamura T | 2007 | Insect Biochem Mol Biol2007，37，11： | 1 |
| 3 | Protective effect of rif ampicin against acute liver injury induced by carbon tetrachloride in mice显示文摘 | Huang R Okuno H Takasu M | 1995 | J pn J Pharmacol1995，69，4： | 1 |
| 4 | Comprisions of efficiency of solar energy utilization and efficiency of solar energy conversion in highyielding rice canopies 显示文摘 | Yamamoto lwaya H K Takasu Y | 2003 | J Agric Meteorol2003，59，1： | 1 |
| 5 | Effects of rifampin on the glutathione depletion and cytoehrome c reduction by acetaminophen reactive metabolites in an in vitro P450 enzyme system显示文摘 | Huang R Okuno H Takasu M | 2000 | Jpn J Pharmacol2000，83，3： | 1 |
| 6 | Valvular and thoracic aortic calcium as a marker of the extent and severity of angiographic coronary artery disease显示文摘 | Yamamoto H Shavelle D Takasu J | 2003 | Am Heart J2003，146，1： | 1 |
| 7 | Preparation of ruthenic acid nanosheets and utilization of its interlayer surface for electrochemical energy storage 显示文摘 | SUGIMOTO W IWATA H YASUNAGA Y MURAKAMI Y TAKASU Y | 2003 | Angewandte Chemie: International Edition2003，42，： | 1 |
| 8 | Management of colorectal cancer in elderly patients over 80 years old显示文摘 | Lsobe H Takasu N Mizutani M | 2007 | Nippon Ronen Igakkai Zasshi2007，44，5： | 1 |
| 9 | Protective effect of rifampicin against acute liver injury induced by carbon tetrachloride in mice显示文摘 | Huang R Okuno H Takasu M | 1995 | Jpn J Pharmacol1995，69，4： | 1 |
| 10 | Withstand voltage characteristics of insulator string covered with snow or ice显示文摘 | Matsuda H Komuro H Takasu K | 1991 | IEEE Trans on Power Delivery1991，6，3： | 1 |
| 11 | Treatment of pretibial myxedema (PTM) with topical steroid ointment application with sealing cover (steroid occlusive dressing technique:steroid ODT) in Graves'patients显示文摘 | Takasu N Higa H Kinjou Y | | 0，，07： | 1 |
| 12 | Surgical treatment of liver injury with microwave tissue coagulation:an experimental study显示文摘 | Takasu A Norio H Sakamoto T | | 0，，： | 1 |
| 13 | An effective case of gemcitabine therapy with post-operative peritoneal recurrence of intrahepatic cholangiocarcinoma显示文摘 | Nakayama A Takasu K Ogiwara H | 2010 | Gan To Kagaku Ryoho2010，37，8： | 1 |
| 14 | Valvular and thoracic aortic calcium as a marker of the extent and severity of angiographic coronary artery disease显示文摘 | YAMAMOTO H SHAVELLE D TAKASU J | 2003 | Am HeartJ2003，146，1： | 1 |
| 15 | Infection with an unenveloped DNA virus(TTV) in patients with acute or chronic liver disease of unknown etiology and in those positive for hepatitis C virus RNA显示文摘 | Ikeda H Takasu M Inoue K | 1999 | J Hepatol1999，30，2： | 1 |
| 16 | Syringoma of the face trea- ted with fractional photothermolysis 显示文摘 | Akita H Takasu E Washimi Y | 2009 | J Cosmet Laser T- her2009，11，4： | 1 |
| 17 | Gabapentin produces PKA-dependent pre-synaptic inhibition of GABAergic synaptic transmission in LC neurons'following partial nerve injury in mice显示文摘 | Takasu K Ono H Tanabe M | 2008 | J Neurochem2008，105，： | 1 |
| 18 | Elastic-plastic Finite Element Analysis of Cold Ring Rolling Process 显示文摘 | Utsunomiya H Saito Y Shinoda T Takasu I | 2002 | Journal of Materials Processing Technology2002，，： | 1 |
| 19 | Infection with an unenveloped DNA virus (TTV)in patients with acute or chronic liver disease of unknown etiology and in those positive for hepatitis C virus RNA显示文摘 | Ikeda H Takasu M Inoue K | 1999 | J Hepatol1999，30，2： | 1 |
| 20 | Accelerated biodegradation of poly (vinyl alcohol) by a glycosidation of the hydroxyl groups显示文摘 | Takasu A Itou H Takada M | 2002 | Polym2002，43，： | 1 |
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