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| 1 | Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease显示文摘AIM To determine how the auto-antibodies(Abs) profiles overlap in chronic hepatitis C infection(CHC) and autoimmune hepatitis(AIH) and correlate to liver disease.METHODS Levels of antinuclear Ab, smooth muscle antibody(SMA) and liver/kidney microsomal-1(LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays. RESULTS We found that AIH patients had more severe liver disease as determined by elevation of total Ig G, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies(auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total Ig G. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with AIH. CONCLUSION Auto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other. | Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 2 | Bioavailability assessment of salbutamol sulfate suppositories in human volunteers显示文摘 | Taha El Zaghhml AA Samy AM | 2004 | Int J Pharm2004，279，2： | 1 |
| 3 | Changes in differential renal function after pyeloplasty in children显示文摘 | Harraz AM Helmy T Taha DE | 2013 | J Urol2013，190，4： | 1 |
| 4 | Berberine potently in hibits protein tyrosine phosphatase 1B: Investigation by doc- king simulation and experimental validation显示文摘 | Bustanji Y Taha MO Yousef AM | | Enzyme Inhib Med Chem0，21，2： | 1 |
| 5 | Ropivacaine in ultrasound-guidedfemoral nerve block : what is the minimal effective anaesthetic con-centration ( EC90) ? 显示文摘 | Taha AM Abd-Elmaksoud AM | 2014 | Anaesthesia2014，69，7： | 1 |
| 6 | Laboratory induced resistance to praziquantel in experimental schistosomiasis 显示文摘 | Ismail MM Taha SA Farghaly AM at al | 1994 | J Egypt Soc Parasitol1994，24，3： | 1 |
| 7 | Prognostic value of serum vascular endothelial growth factor in Egyptian females with metastatic triple negative breast cancer显示文摘 | Taha FM Zeeneldin AA Helal AM | 2009 | Clin Biochem2009，42，1314： | 1 |
| 8 | Effect of smok- ing on sperm vitality, DNA integrity, seminal oxidative stress,zinc in fertile men显示文摘 | Taha EA Ez-Aldin AM Sayed SK | 2012 | Uology2012，80，4： | 1 |
| 9 | Long-term outcomes of isolated liver transplantation for short bowel syndrome and intestinal failure-associated liver disease显示文摘 | Taha AM Sharif K Johnson T | 2012 | J Pediatr Gastroenterol Nutr2012，54，4： | 1 |
| 10 | Prognostic value of serumvascular endothelial growth factor in Egyptian females with meta-static triple negative breast cancer显示文摘 | Taha FM Zeeneldin AA Helal AM | 2009 | Clin Biochem2009，42，1314： | 1 |
| 11 | ^13C-NMR spectroscopy of tropane alkaloids显示文摘 | Taha AM Racker G | 1978 | J of Pharm Sci1978，67，6： | 1 |
| 12 | Berberine potendy inhibitsprotein tyrosine phosphatase IB: investigation by docking simulation andexperimental validation 显示文摘 | Bustanji Y Taha MO Yousef AM | 2006 | J Enzyme Inhib Med Chem2006，21，2： | 1 |
| 13 | Effect of smoking on sperm vitality,DNA integrity,seminal oxidative stress,zinc in fertile men显示文摘 | Taha EA Ez-Aldin AM Sayed SK | 2012 | Urology2012，80，4： | 1 |
| 14 | Some experimental data on workability of aluminum particulate-reinforced metal-matrix composites 显示文摘 | TAHA M A EL-MAHALLAWY NA EL-SABBAGH AM | 2008 | Journal of Materials Processing Technology2008，202，38： | 1 |
| 15 | Effect of smoking on sperm vitality, DNA integrity, seminal oxidative stress, zinc in fertile men 显示文摘 | Taha EA Ez-Aldin AM Sayed SK | 2012 | U rol2012，80，4： | 1 |
| 16 | Laboratory induced resistance to praziquantel in experimental schistosomiasis 显示文摘 | Ismail MM Taha SA Farghaly AM | 1994 | Egypt Soc Parasitol1994，24，： | 1 |
| 17 | Effect of chemicaladditives on flow characteristics of coal slurries显示文摘 | Mosa E S Saleh AM Taha T A | 2008 | Physicochemical Problems of Mineral Processing2008，，42： | 1 |
| 18 | Brief reports: ultrasound-gulded obturator nerve block: a proximal interfascial technique显示文摘 | Taha AM | 2012 | Anesth Analg2012，114，1： | 1 |
| 19 | Long-term outcomes of iso- lated liver transplantation for short bowel syndrome and intestinal failure-associated liver disease 显示文摘 | Taha AM Sharif K Johnson T | 2012 | J Pediatr Gastroenterol Nutr2012，54，4： | 1 |
| 20 | Changes in Differential Renal Function after Pyeloplasty in Children 显示文摘 | Harraz AM Helmy T Taha DE | 2013 | J Uro12013，190，4： | 1 |
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