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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Nanofluidics in the Debye layer at hydrophilic and hydrophobic surfaces显示文摘 | Bouzigues C I Tabeling P Bocquet L | 2008 | Phys Rev Letters2008，101，11： | 1 |
| 3 | Expression profile of the sphingusine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease显示文摘 | Cordts F Pitson S Tabeling C | 2011 | Life Sci2011，89，2122： | 1 |
| 4 | diltiazem provides higher internal mammary artery flow than nitroglycerin during coronary artery bypass grafting 显示文摘 | Tabel Y Erdal C | 2004 | European Journal of Cardiothoracic Surgery2004，25，： | 1 |
| 5 | Clinical features ofchildren with Henoch-Schonlein purpura:risk factors assoc-iated with renal involvement显示文摘 | Tabel Y Inanc F C Dogan D G | | Iran J Kidney Dis0，6，4： | 1 |
| 6 | Characterization of a MEMS-fabricated mixing device 显示文摘 | LEE Y K TABELING P SHIH C | 2000 | Microelectrome- chanical Systems(MEMS)2000，，： | 1 |
| 7 | Autoantibodies to an- giotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis 显示文摘 | Kill A Tabeling C Undeutsch R | 2014 | Arthritis Res Ther2014，16，1： | 1 |
| 8 | Clinical features of children with Henoch-Schonlein purpura: risk factors associ- ated with renal involvement显示文摘 | Tabel Y Inanc F C Dogan D G | 2012 | Iranian journal of kidney dis- eases2012，6，4： | 1 |
| 9 | Clinical features of children with Henoch-Schonlein purpura:risk factors associated with renalinvolvement显示文摘 | Tabel Y Inanc F C Dogan D G | 2012 | Iran J Kidney Dis2012，6，4： | 1 |
| 10 | Slippage of water past superhy- drophobic carbon nanotube forests in microehannels显示文摘 | Joseph P Cottin-Bizonne C Benoit J -M Ybert C Journet C Tabeling P Bocquet L | 2006 | Physical Review Letters2006，97，15： | 1 |
| 11 | Obstructed breakup of slender drops in microfluidic T junction显示文摘 | Leshansky A M Afkhmi S Jullien M C Tabeling P | 2012 | Physical Review Letters2012，108，26： | 1 |
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