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| 1 | Carbon Nanotubes in Biology and Medicine:In vitro and in vivo Detection,Imaging and Drug Delivery显示文摘Carbon nanotubes exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few years.In this comprehensive review,we summarize the main results from our and other groups in this field and clarify that surface functionalization is critical to the behavior of carbon nanotubes in biological systems.Ultrasensitive detection of biological species with carbon nanotubes can be realized after surface passivation to inhibit the non-specific binding of biomolecules on the hydrophobic nanotube surface.Electrical nanosensors based on nanotubes provide a label-free approach to biological detection.Surface-enhanced Raman spectroscopy of carbon nanotubes opens up a method of protein microarray with detection sensitivity down to 1 fmol/L.In vitro and in vivo toxicity studies reveal that highly water soluble and serum stable nanotubes are biocompatible,nontoxic,and potentially useful for biomedical applications.In vivo biodistributions vary with the functionalization and possibly also size of nanotubes,with a tendency to accumulate in the reticuloendothelial system(RES),including the liver and spleen,after intravenous administration.If well functionalized,nanotubes may be excreted mainly through the biliary pathway in feces.Carbon nanotube-based drug delivery has shown promise in various In vitro and in vivo experiments including delivery of small interfering RNA(siRNA),paclitaxel and doxorubicin.Moreover,single-walled carbon nanotubes with various interesting intrinsic optical properties have been used as novel photoluminescence,Raman,and photoacoustic contrast agents for imaging of cells and animals.Further multidisciplinary explorations in this field may bring new opportunities in the realm of biomedicine. | Zhuang Liu Scott Tabakman Kevin Welsher Hongjie Dai | 2009 | Nano Research2009，2，2： | 50 |
| 2 | Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared显示文摘Single-walled carbon nanotubes(SWNTs)with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular specificity.Multiplexed Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of SWNTs.Ex vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor(EGFR)on LS174T colon cancer cells from cell culture to in vivo tumor growth.This is the first time five-color multiplexed molecular imaging has been performed in the near-infrared(NIR)region under a single laser excitation.Near zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low,smooth autofluorescence background of biological species. | Zhuang Liu Scott Tabakman Sarah Sherlock Xiaolin Li Zhuo Chen Kaili Jiang Shoushan Fan Hongjie Dai | 2010 | Nano Research2010，3，3： | 11 |
| 3 | Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence显示文摘 | Bo Zhang Jordan Price Guosong Hong Scott M. Tabakman Hailiang Wang Justin A. Jarrell Ju Feng Paul J. Utz Hongjie Dai | 2013 | Nano Research2013，6，2： | 2 |
| 4 | Interactions between the cells of the immune and nervous system : neurotrophins as neuroprotection mediators in CNS injury显示文摘 | Tabakman R Lecht S Sephanova S | 2004 | Prog Brain Res2004，146，： | 1 |
| 5 | Atomic Layer Deposi- tion of Metal Oxides on Pristine and Functionalized Gra- phene 显示文摘 | WANG X TABAKMAN S M DAI H | 2008 | Journal of the American Chemical Society2008，130，26： | 1 |
| 6 | Interactions between the cells of the immune and nervous system:neurotrophinsas neuroprotection mediators in CNS injury显示文摘 | TABAKMAN R LECHT S SEPHANOVA S | 2004 | Prog Brain Res2004，146，3： | 1 |
| 7 | Neuroprotective effects of camosine and homocamosine on pheochromocytoma PC12 cells exposed to ischemia 显示文摘 | Tabakman R Lazarovici P Kohen R | 2002 | J Neurosci Res2002，68，： | 1 |
| 8 | Interractions between the cells of the immune and nervous system: heurotrophins as neuroprotection mediators in CNS injury显示文摘 | Tabakman R Lecht S Sephanova S | 2004 | Prog Brain Res2004，146，23： | 1 |
| 9 | Neuroprotective and neurotoxic effects of monoamine oxidase B inhibitors and derived metabolites under ischemia in PC12 cells显示文摘 | Abu Raya S Tabakman R Blaugrund E | 2002 | Eur J Pharmacol2002，434，： | 1 |
| 10 | Separation of nanoparticles in a density gradient:FeCo@C and gold nanocrystals显示文摘 | Sun X M Tabakman S M Seo W S | 2008 | Angewandte Chemie International Edition2008，48，： | 1 |
| 11 | Apoptotic characteristics of cell death and the neuroprotective effect of homocarnosine on pheochromocy-toma PC12 cells exposed to ischemia显示文摘 | Tabakman R Jiang H Levine RA | | 0，，04： | 1 |
| 12 | PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation显示文摘 | PRENCIPE G TABAKMAN SM WELSHER K | 2009 | J Am Chem Soe2009，131，13： | 1 |
| 13 | Interac- tions between the cells of the immune and nervous system neurotrophins as neuroprotection mediators in CNS injury显示文摘 | TABAKMAN R LECHT S SEPHANOVA S | 2004 | Progress in Brain Research2004，146，： | 1 |
| 14 | Neuroprotective and neurotoxic effects of monoamine oxidase B inhibitors and derived metabolites under ischemia in PC12 cells显示文摘 | Abu Raya S Tabakman R Blaugrund E | 2002 | Eur J Pharmacol2002，434，： | 1 |
| 15 | Atomic Layer Deposition of Metal Oxides on Pristine and Funetio- nalized Graphene显示文摘 | WANG Xin-ran TABAKMAN S M DAI Hong-jie | 2008 | Journal of the American Chemical Society2008，30，： | 1 |
| 16 | Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia 显示文摘 | Tabakman R Lazarovici P Kohen R | 2002 | J Neurosci Res2002，68，4： | 1 |
| 17 | Apoptotic characteristics of cell death and the neuroprotective effect of homocarnosine on pheochromocytoma PC12 cells exposed to ischemia显示文摘 | Tabakman R Jiang H Levine RA | | 0，，04： | 1 |
| 18 | Neuroprotective and neurotoxic effects of monoamine oxidase B inhibitors and derived metabolites underischemia in PC12 cells显示文摘 | Aburaya S Tabakman R Blaugrund E | 2002 | Eur J Pharmacol2002，434，3： | 1 |
| 19 | Ultras- mall reduced graphene oxide with high near-infrared ab- sorbance for photothermal therapy显示文摘 | Robinson J T Tabakman S M Liang Y Y | 2011 | Journal of the A- merican Chemical Society2011，133，17： | 1 |
| 20 | Neuroprotection by monoamine oxidase B inhibitors:a therapeutic strategy for Parkinson's disease显示文摘 | Lecht S Lazarovici P | 2004 | Bio Essays2004，26，1： | 1 |
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