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| 1 | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide显示文摘Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 4 |
| 2 | Phenotypic instability and rapid gene silencing in newly formed Arabidopsis alloteraploids显示文摘 | Comai L Tyagi A P Winter K Holmes-Davis R Reynolds S H Stevens Y Byers B | 2000 | Plant Cell2000，12，9： | 2 |
| 3 | Assessment of the efficiency of various gene promoters via biolistics in leaf and regenerating seed callus of millets,Eleusine coracana and Echinochloa crusgalli显示文摘 | GUPTA P RAGHUVANSHI S TYAGI A K | 2001 | Plant Biotechnol2001，18，： | 1 |
| 4 | Proteomic investigation on chron- ic bladder irritation in the rat 显示文摘 | Tyagi P Chen X Hayashi Y | 2008 | Urology2008，71，3： | 1 |
| 5 | Bevacizumab,when added to paclitaxel/carboplatin,prolongs survival in previously untreated petients with advanced non-small cell lung cancer:preliminary results from the ECOG 4599 trial显示文摘 | Tyagi P | 2005 | Clin Lung Cancer2005，6，2： | 1 |
| 6 | SCS-CN-basedmodeling of sediment yield显示文摘 | Mishra S K Tyagi J V Singh V P | 2006 | Hydrol2006，324，14： | 1 |
| 7 | The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases 显示文摘 | Tyagi S Gupta P Saini AS | 2011 | Adv Pharm Technol Res2011，2，4： | 1 |
| 8 | Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells显示文摘 | TYAGI A K AGARWAL C SINGH R P | 2003 | Biochem Biophys Res Comm2003，312，4： | 1 |
| 9 | Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus role of insulin and C-peptide显示文摘 | Bratcher A P Rodriguez W E Tyagi S C | 2005 | Cell Biochem2005，96，6： | 1 |
| 10 | Quaternary Pyridinium Salts: a review显示文摘 | Madaan P Tyagi VK | 2008 | Journal of Oleo Science2008，57，4： | 1 |
| 11 | Di 2-ethylhexylphtalate in the aquatic and terrestrial environment: a critical review 显示文摘 | Magdouli S Daghrir R Brar S K Drogui P Tyagi R D | 2013 | Journal of Environmental Management2013，127，： | 1 |
| 12 | Silibinin acti- vates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cipl/p21 in apoptosis induction in bladder tran- sitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2显示文摘 | TYAGI A SINGH R P AGARWAL C | 2006 | Carcinogenesis2006，27，11： | 1 |
| 13 | Recent advances in intravesical drug/gene delivery显示文摘 | Tyagi P Wu PC Chancellor M | 2006 | Mol Pharm2006，3，4： | 1 |
| 14 | Influence of choroidal neovascula-rization and biodegradable polymeric particle size on trans- scleral sustained delivery of triamcinolone acetanide 显示文摘 | Kadam RS Tyagi P Edelhanser HF | 2012 | Ira J Pharm2012，434，12： | 1 |
| 15 | Di-and tetranuclear ruthenium(Ⅱ)and/or osmium(Ⅱ)complexes of polypyridyl ligands bridged by a fully conjugated aromatic spacer:synthesis,characterization,and electrochemical and photophysical studies 显示文摘 | BILAKHIYA A K TYAGI B PAUL P | 2002 | Inorg Chem2002，41，15： | 1 |
| 16 | Assessment ofgroundwater contamination from fertilizers in the Delhi area based on ^18 O, NO3 and K^+ composition 显示文摘 | Datta P S Deb D L Tyagi S K | 1997 | Journal of Contaminant Hydrology1997，，27： | 1 |
| 17 | Vatalanib (PTK787/ZK 222584) in combination with FOLFOX4 versus FOLFOX4 alone as first-line treatment for colorectal cancer: preliminary results from the CONFIRM-1 trial 显示文摘 | TYAGI P | 2005 | Clin Colorectal Cancer2005，5，1： | 1 |
| 18 | Management of difficult airway in intratracheal tumor surgery显示文摘 | Goyal A Tyagi I Tewari P | 2005 | BMC Ear Nose Throat Disord2005，7，5： | 1 |
| 19 | SCS-CN-based Modeling of Sediment Yield 显示文摘 | Mishra S K Tyagi J V Singh V P | 2006 | Journal of Hydrology2006，324，： | 1 |
| 20 | Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis显示文摘 | Tyagi P Tyagi V Yoshimura N | 2009 | J Inflamm(Lond)2009，6，： | 1 |
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