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| 1 | Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer显示文摘AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. | Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan | 2011 | World Journal of Gastroenterology2011，17，16： | 10 |
| 2 | Precancerous lesions of oral mucosa显示文摘Precancerous lesions of oral mucosa, known as potentially malignant disorders in recent years, are consists of a group of diseases, which should be diagnosed in the early stage. Oral leukoplakia, oral submucous fibrosis, and oral erythroplakia are the most common oral mucosal diseases that have a very high malignant transformation rate. Oral lichen planus is one of the potentially malignant disorders that may be seen in six different subtypes including papular, reticular, plaquelike, atrophic, erosive, and bullous type, clinically. Atrophic and erosive subtypes have the greater increased malignant transformation risk compared to another subtypes. Although there are various etiological studies, the etiology of almost all these diseases is not fully understood. Geographically, etiologic factors may vary.The most frequently reported possible factors are tobacco use, alcohol drinking, chewing of betel quid containing areca nut, and solar rays. Early diagnosis is very important and can be lifesaving, because in late stages, they may be progressed to severe dysplasia and even carcinoma in situ and/or squamous cell carcinoma. For most diseases, treatment results are not satisfactory in spite of miscellaneous therapies. While at the forefront of surgical intervention, topical and systemic treatment alternatives such as corticosteroids, calcineurin inhibitors, and retinoids are widely used. | Gurkan Yardimci Zekayi Kutlubay Burhan Engin Yalcin Tuzun | 2014 | World Journal of Clinical Cases2014，2，12： | 5 |
| 3 | The effect of inter-stitial air pressure gradients on the discharge rate from Bins显示文摘 | Nedderman R M Tuzun U Thorpe R B | 1983 | Powder Technology1983，，35： | 1 |
| 4 | Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D显示文摘 | MOYNE A L CLEVELAND T E TUZUN S | 2004 | FEMS Microbiol Lett2004，234，1： | 1 |
| 5 | An in vitro per- spective to cholinesterase inhibitory and antioxidant activi- ty of five Gentiana species and Gentianella caucasea 显示文摘 | Senol FS Tuzun CY Toker G | 2012 | Int J Food Sci Nutr2012，63，7： | 1 |
| 6 | Paraneoplastic anti- N-methyl D-aspartate receptor encephalitis associated with ovarian teratoma显示文摘 | Dalmau J Tuzun E Wu H Y | 2007 | Ann Neurol2007，61，1： | 1 |
| 7 | Total heart replacement using dual intracorporeal continuous-flow pumps in a chronic bovine model:a feasibility study显示文摘 | Frazier OH Tuzun E Cohn WE | | 0，，： | 1 |
| 8 | Paraneoplastic anti-N-methylD-aspartate receptor encephalitis associated with ovarian teratoma显示文摘 | Dalmau J Tuzun E Wu HY | 2007 | Ann Neurol2007，61，1： | 1 |
| 9 | Paraneoplastic anti-N-methyl- D-aspartate receptor encephalitis associated with ovarian teratoma显示文摘 | Dalmau J Tuzun E Wu HY | 2007 | Ann Neurol2007，61，1： | 1 |
| 10 | Biekerstaff's encephali- tis and Miller Fisher syndrome associated with voltage gated potassium channel and novel antineuronal antibodies显示文摘 | Tuzun E Kurtuneu M Lang B et a/ | 2010 | Eur J Neurol2010，17，0： | 1 |
| 11 | MRI findings in parosteal osteosarcoma : correlation with histopathology 显示文摘 | Donmez FY Tuzun U Basaran C | 2008 | Diagn Interv Radiol2008，14，3： | 1 |
| 12 | Stratification in poured granular heaps显示文摘 | Baxter J Tuzun U Heyes D | 1998 | Nature1998，391，8： | 1 |
| 13 | Molecular characterization and analysis of the operon encoding the antifungal lipocptidc bacillomycin D显示文摘 | Moyne A L Clevcland T E Tuzun S | 2004 | FEMS Microbiology Letter2004，234，1： | 1 |
| 14 | The dynamics of single air bubbles and alcohol drops in sunflower oil at various temperatures 显示文摘 | Duangsuwan W Tuzun U Sermon PA | 2011 | AIChE Journal2011，57，4： | 1 |
| 15 | A two-phase tabu search approach to the location muting problem显示文摘 | Tuzun D Burke L 1 | 1999 | European Journal of Operational Research1999，，116： | 1 |
| 16 | Neuronal acetylcholine receptor alpha9-subunit:a possible central nervous system autoantigen显示文摘 | Tuzun E | 2006 | Med Hypotheses2006，67，： | 1 |
| 17 | Equilibrium and kinetic studies on biosorption of Hg(Ⅱ),Cd(Ⅱ) and Pb(Ⅱ)ions onto microalgae Chlamydomonas reinhardtii显示文摘 | Tuzun I Bayramoglu G Yalcin E | 2005 | J Environ Manag2005，77，： | 1 |
| 18 | Paraneoplastic anti-N-methyl- D-aspartate receptor encephalitis associated with ovarian teratoma 显示文摘 | Dalmau J Tuzun E Wu HY | 2007 | Ann Neurol2007，61，1： | 1 |
| 19 | Effect of pin tip velocity, ball density and ball size on grinding kinetics in a stirred ball mill 显示文摘 | Tuzun M A | 1995 | lnt J Miner Process1995，43，： | 1 |
| 20 | Intramedullary spinal tuberculoma 显示文摘 | Kayaoglu C R Tuzun Y Boga Z | 2000 | Spine2000，25，17： | 1 |
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