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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Simple hematological predictors of AF recurrence in patients undergoing atrial fibrillation ablation显示文摘Backgound Red cell distribution width(RDW) and neutrophil-to-lymphocyte ratio(NLR) are simple hematologic indices that have been used to predict adverse outcomes in different clinical settings. The aim of our study is to determine whether RDW and NLR can predict atrial fibrillation(AF) recurrence in patients undergoing AF ablation. Methods Consecutive patients, without known hematological disorders, who underwent AF catheter ablation between January 2014 and April 2017 were enrolled into this study. Blood samples were taken one day before and five hours after the ablation procedure. Results A total of 346 patients(224 males(65%), mean age: 59 ± 11 years old) were included. After a mean follow up of 26.2 ± 12.1 months, 80(23.1%) patients experienced late AF recurrence(defined as any recurrence after the blanking period of three months), while 97(28%) patients experienced early AF recurrence during the blanking period. Univariate analysis showed that early arrhythmia recurrence, type of AF and NLR after the procedure were significantly associated with late AF recurrence, while early arrhythmia recurrence and NLR remained significant in multivariate analysis. RDW was not associated with late AF recurrence. None of the parameters above predicted early arrhythmia recurrence. Conclusions Simple and inexpensive hematological indices such as NLR should be evaluated for their ability to predict AF recurrence in patients undergoing catheter ablation in larger prospective studies. | George Bazoukis Konstantinos P Letsas Konstantinos Vlachos Athanasios Saplaouras Dimitrios Asvestas Konstantinos Tyrovolas Aikaterini Rokiza Eirini Pagkalidou Gary Tse Stavros Stavrakis Antonios Sideris Michael Efremidis | 2019 | Journal of Geriatric Cardiology2019，16，9： | 4 |
| 3 | An improved Hilbert Huang transform and its application in vibration signal analysis显示文摘 | PengZ K Tse P W Chu F L | 2005 | Journal of Sound and Vibration2005，286，12： | 1 |
| 4 | An improved HilbertHuang transform and its application in vibration signal analysis显示文摘 | PENG Z K TSE P W CHUA F L | 2005 | Journal of Sound and Vibration2005，186，2： | 1 |
| 5 | An innovative design for using flexible printed coils for magnetostrictive-based longitudinal guided wave sensors in steel strand inspection显示文摘 | Tse P W Liu X C Liu Z H Wu B He C F Wang XJ | 2011 | Smart Materials and Structures2011，20，05： | 1 |
| 6 | Machine fault diagnosis through an effective exact wavelet analysis 显示文摘 | Tse P W Yang W X Tam H Y | 2004 | Journal of Sound and Vibration2004，277，45： | 1 |
| 7 | Mergers and investments in cost reduction with private information revisted 显示文摘 | Tse M K S | 1997 | International Journal of Industrial Organization1997，15，： | 1 |
| 8 | A comparison study of improved Hilbert Huang transform and wavelet transform: application to fault diagnosis for rolling bear ing显示文摘 | Peng Z Tse P Chu F | 2005 | Mechanical Systems and Signal Processing2005，19，5： | 1 |
| 9 | Models of consumer satisfaction formation: An extension 显示文摘 | Tse D K Wilton P C | 1988 | Journal of Marketing Research1988，，： | 1 |
| 10 | Economic perspectives of aerodynamic treatments of square tall buildings显示文摘 | Tse K T Hitchcock P A Kwok K C S | 2009 | Journal of Wind Engineering and Industrial Aerodynamics2009，97，910： | 1 |
| 11 | Faulty bearing signal recovery from large noise using a hybrid method based on spectral kurtosis and ensemble empirical mode de- composition显示文摘 | Guo W Tse P W Djordjevich A | 2012 | Measurement2012，45，5： | 1 |
| 12 | Application of mother wavelet functions for automatic gear and bearing fault diagnosis显示文摘 | Rafiee J Rafiee M A Tse P W | 2010 | Expert Systems with Applications2010，37，6： | 1 |
| 13 | Hooking the reader:A corpus study of evaluative that in abstracts显示文摘 | HYLAND K TSE P | 2005 | English for Specific Purposes2005，，2： | 1 |
| 14 | Opportunistic beamfor- ming using dumb antennas显示文摘 | VISWANATH P TSE D N C LAROIA R | 2002 | IEEE Trans on Information Theo- ry2002，48，6： | 1 |
| 15 | Opportunistic beamforming using dumb antennas显示文摘 | VISWANATH P TSE D N C LAROIA R | 2002 | Information Theory IEEE Transactions on2002，48，6： | 1 |
| 16 | Prevention of atrial fibrillation recurrence by statin therapy in patients with lone atrial fibrillation after successful cardioversion显示文摘 | Siu C W Lau C P Tse H F | 2003 | Am J Cardiol2003，92，11： | 1 |
| 17 | Wavelet analysis and its envelope detection for rolling element bearing fault diagnosis-their affectivities and flexibilities显示文摘 | TSE P W PENG Y H YAM R | 2001 | Journal of Vibration and Acoustics2001，，3： | 1 |
| 18 | Predicting protein druggability显示文摘 | Hajduk P J Huth J R Tse C | 2005 | Drug Discovery Today2005，10，2324： | 1 |
| 19 | Faulty bearing signal recovery from large noise using a hybrid method based on spectral kurtosis and ensemble empirical mode decomposition显示文摘 | Guo W Tse P W Djordjevich A | 2012 | Measurement2012，45，： | 1 |
| 20 | Use of autocorrelation of wavelet coefficients for fault diagnosis 显示文摘 | Rafiee J TSE P W | 2009 | Mechanical Systems and Signal Processing2009，23，5： | 1 |
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