|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 2 | Gas-particle concentrations and distribution of aliphatic hydrocarbons,PAHs,PCBs and PCDD/Fs in the atmosphere of Athens(Greece)显示文摘 | Mandalakis M Tsapakis M Tsoga A Stephanou E G | 2002 | Atmos Environ2002，36，： | 1 |
| 3 | Source apportionment of urban particulate aliphatic and polynuclear aromatic hydrocarbons (PAHs) using multivariate methods 显示文摘 | Kavouras I G Koutrakis P Tsapakis M | 2001 | Environmental Science and Technology2001，35，11： | 1 |
| 4 | Detection of congenital heart defects throughout pregnancy; impact of first trimester ultrasound screening for cardiac abnormalities 显示文摘 | Eleftheriades M Tsapakis E Sotiriadis A | 2012 | Matern Fetal Neonatal Meal2012，25，12： | 1 |
| 5 | Gas-particle concentrations and distribution of aliphatic hydrocarbons,PAHs,PCBs and PCDD/Fs in the atmosphere of Athens (Greece)显示文摘 | Tsapakis M Tsoga A | 2002 | Atmos Environ2002，36，25： | 1 |
| 6 | Prenatal diagnosis of fetal left ventricular non-compaction cardiomyopathy 显示文摘 | Tsapakis EG Eleftheriades M Daskalakis G | 2012 | Ultra- sound Obstet Gyneco12012，39，5： | 1 |
| 7 | Journal of Psychopharmacology显示文摘 | Wolff K Tsapakis E M Winstock A R Hartley D Holt D Forsling M L Aitchison K J | 2006 | 20(3):4002006，20，3： | 1 |
| 8 | Source apportionment of urban particulate aliphatic and polynuclear aromatic hydrocarbons (PAHs) using multivariate methods 显示文摘 | Kavouras I G Koutrakis P Tsapakis M | 2001 | Environmental science & technology2001，35，11： | 1 |
| 9 | Gas-particle concentrations and distribution of aliphatic hydrocarbons, PAHs, PCBs and PCDD/Fs in the atmosphere of Athens (Greece)显示文摘 | Mandalakis M Tsapakis M Tsoga A | 2002 | Atmos Enviyon2002，36，： | 1 |
| 10 | Gas- particle concentrations and distribution of aliphatic hydrocarbons, PAHs, PCBs andPCDD/Fs in the atmosphere of Athens (Greece) 显示文摘 | Mandalakis M Tsapakis M Tsoga A | 2002 | Atmospheric Environment2002，，36： | 1 |
| 11 | Collection of gas and particle semi-volatile organic compounds:use of an oxidant denuder to minimize polycyclic aromatic hydrocarbons degradation during high-volume air sampling显示文摘 | Tsapakis M Stephanou E G | 2003 | Atmospheric Environment2003，37，4： | 1 |
| 12 | Source apportionment of urban particulate aliphatic and polynuclear aromatic hydrocarbons (PAHs) using multivariate methods显示文摘 | KAVOURAS I G KOUTRAKIS P TSAPAKIS M | 2001 | Atmospheric Environment2001，，35： | 1 |
| 13 | Source apportionment urban particulate aliphatic and polynuclear aromatic hydrocarbons (PAHs) using multivariate methods 显示文摘 | Kavouras I G Koutrakis P Tsapakis M Lagoudaki E Stephanou E G Baer D V Oyola P | 2001 | Environ Sci Technol2001，35，11： | 1 |
| 14 | Seasonal variability in sediment profiles beneath fish farm cages in the mediterranean显示文摘 | Karakassis I Tsapakis M Hatziyanni E | 1998 | Marine ecology progress series1998，162，： | 1 |
| 15 | Impact of cage farming of fish on the seabed in three Mediterranean coastal areas显示文摘 | Karakassis I Tsapakis M Hatziyanni E | 2000 | ICES Journal of Marine Science2000，57，5： | 1 |
| 16 | Evaluation of atmospheric transport as a nonpoint source of polycyclic aromatic hydrocarbons in marine sediments of the Eastern Mediterranean显示文摘 | TSAPAKIS M STEPHANOU E G KARAKASSIS I | 2003 | Marine Chemistry2003，80，4： | 1 |
| 17 | Radiation safety in abdominal computed tomography 显示文摘 | Tsapaki V Rehani M Saini S | 2010 | Semin Ultrasound CT MR2010，31，1： | 1 |
| 18 | Gas/particle concentrations and distribution of aliphatic hydrocarbons, PAHs, PCBs and PCDD Fs in the atmosphere of Athens (Greece) 显示文摘 | Manolis M Tsapakis M Tsoga A | 2002 | Atmosphere Environment2002，36，25： | 1 |
| 19 | Source apportionment of urban particulate aliphatic and polynuclear aromatic hydrocarbons (PAHs) using multivariate methods显示文摘 | Kavouras I G Koutrakis P Tsapakis M | 2001 | Environmental Science and Technology2001，35，11： | 1 |
| 20 | Gas-particle concentrations and distribution of aliphatic hydrocarbons, PAHs,PCBs and PCDD/Fs in the atmosphere of Athens (Greece) 显示文摘 | Mandalakis M Tsapakis M Tsoga A | 2002 | Atmospheric Environment2002，36，25： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员