|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal crohn's disease显示文摘AIM To examine the relationship between elevated granulocyte-macrophage colony-stimulating factor(GMCSF) auto-antibodies(Ab) level and time to surgical recurrence after initial surgery for Crohn's disease(CD). METHODS We reviewed 412 charts from a clinical database at tertiary academic hospital. Patients included in the study had ileal or ileocolonic CD and surgical resection of small bowel or ileocecal region for management of disease. Serum samples were analyzed for serological assays including GM-CSF cytokine, GM-CSF Ab, ASCA Ig G and Ig A, and genetic markers including SNPs rs2066843, rs2066844, rs2066845, rs2076756 and rs2066847 in NOD2, rs2241880 in ATG16 L1, and rs13361189 in IRGM. Cox proportional-hazards models were used to assess the predictors of surgical recurrence.RESULTS Ninety six percent of patients underwent initial ileocecal resection(ICR) or ileal resection(IR) and subsequently 40% of patients required a second ICR/IR for CD. GMCSF Ab level was elevated at a median of 3.81 mcg/mL. Factors predicting faster time to a second surgery included elevated GM-CSF Ab [hazard ratio(HR) 3.52, 95%CI: 1.45-8.53, P = 0.005] and elevated GM-CSF cytokine(HR = 2.48, 95%CI: 1.31-4.70, P = 0.005). Factors predicting longer duration between first and second surgery included use of Immunomodulators(HR = 0.49, 95%CI: 0.31-0.77, P = 0.002), the interaction effect of low GM-CSF Ab levels and smoking(HR = 0.60, 95%CI: 0.45-0.81, P = 0.001) and the interaction effect of low GM-CSF cytokine levels and ATG16 L1(HR = 0.65, 95%CI: 0.49-0.88, P = 0.006).CONCLUSION GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive CD behavior. | Grace Gathungu Yuanhao Zhang Xinyu Tian Erin Bonkowski Leahana Rowehl Julia Krumsiek Billy Nix Claudia Chalk Bruce Trapnell Wei Zhu Rodney Newberry Lee Denson Ellen Li | 2018 | World Journal of Gastroenterology2018，24，5： | 5 |
| 2 | In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium显示文摘 | Rosenfeld MA Yoshimura K Trapnell BC | 1992 | Cell1992，68，1： | 1 |
| 3 | Ultrafast and memory- ef{cient alignment of short DNA sequences to the human ge- nome 显示文摘 | Langmead B Trapnell C Pop M | 2009 | Genome Biology2009，，： | 1 |
| 4 | Differential analysis of gene regulation at transcript resolution with RNA-seq显示文摘 | Trapnell C Hendrickson DG Sauvageau M | 2013 | Nat Biotechnol2013，31，： | 1 |
| 5 | Inhaled granulocyte/macrophage colony stimulating factor as Therapy for pulmonaryalveolar proteinosis显示文摘 | Tazawa R Trapnell BC Inoue Y | 2010 | Am J Respir Crit Care Med2010，181，12： | 1 |
| 6 | The molecular basis of pulmonary alveolarproteinosis显示文摘 | Carey B Trapnell BC | 2010 | Clin Immunol2010，135，2： | 1 |
| 7 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome 显示文摘 | Langmead B Trapnell C Pop M | 2009 | Genome Biology2009，10，3： | 1 |
| 8 | Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy显示文摘 | Mittereder N March KL Trapnell BC | 1996 | Virol1996，70，3： | 1 |
| 9 | Comparative studyof high-resolution CT findings between autoimmune andsecondary pulmonary alveolar proteinosis显示文摘 | Ishii H Trapnell BC Tazawa R | 2009 | Chest2009，136，5： | 1 |
| 10 | Characteristics of a large co- hort of patients with autoimmune pulmonary alveolar proteinosis in Ja- pan显示文摘 | Inoue Y Trapnell BC Tazawa R | 2008 | Am J Respir Crit Care Med2008，，177： | 1 |
| 11 | Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses显示文摘 | Cabili M N Trapnell C Goff L | 2011 | Genes development2011，25，18： | 1 |
| 12 | Private Self-consciousness and the Five-Factor Model of Personality: Distinguishing Rurnination from Reflection显示文摘 | Trapnell P D Campbell J D | 1999 | Journal of Personality and Social Psychology1999，，76： | 1 |
| 13 | Transcript as sembly and quantification by RNA-Seq reveals unannotated transcripts and isoIorm switching during cell differentiation 显示文摘 | Trapnell C Williams B A Pertea G | 2010 | NatBiotechnol2010，28，5： | 1 |
| 14 | Discovering splice junctions with RNA-Seq 显示文摘 | Trapnell C Pachter L Salzberg SL | 2009 | Bioinformatics2009，25，9： | 1 |
| 15 | Pulmonary alveolar proteinosis显示文摘 | Trapnell BC Whitsett JA Nakata K | 2003 | The New England Journal of Medicine2003，349，： | 1 |
| 16 | Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation显示文摘 | TRAPNELL C WILLIAMS B A PERTEA G | 2010 | Nature Biotechnology2010，28，5： | 1 |
| 17 | Identification of novel transcripts in annotated genomes using RNA-Seq 显示文摘 | Roberts A Pimentel H Trapnell C | 2011 | Bioinformatics2011，27，17： | 1 |
| 18 | Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan显示文摘 | Inoue Y Trapnell B C Tazawa R | 2008 | Am J Respir Crit Care Med2008，177，7： | 1 |
| 19 | Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolarproteinosis显示文摘 | Tazawa R Trapnell BC Inoue Y | 2010 | Am J Respir Crit Care Med2010，181，12： | 1 |
| 20 | Adenoviral Vector for Gene Transfer显示文摘 | Trapnell BC | 1993 | Adv Drug Deliv Rev1993，，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员