|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antiviral treatment of hepatitis C 显示文摘 | Toniutto P Fabris C Pirisi M | 2006 | Expert Opin Pharmacother2006，7，15： | 1 |
| 2 | Usefulness of six non-proprietary indirect markers of liver fibrosis in patients with chronic hepatitis C 显示文摘 | Fabris C Smirne C Toniutto P | 2008 | Clin Chem Lab Med2008，46，2： | 1 |
| 3 | Apolipoprotein E geno- types modulate fibrosis progression in patients with chronic hepatitis C and persistently normal transaminases 显示文摘 | Fabris C Vandelli C Toniutto P | 2011 | J Gastroenterol Hep- atol2011，26，2： | 1 |
| 4 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 5 | Evaluation of donor hepatic iron concentration as a factor of early fibrotic progression after liver transplantation 显示文摘 | Toniutto P Fabris C Bortolotti N | 2004 | J Hepatol2004，41，： | 1 |
| 6 | Antiviral treatment of hepatitis C 显示文摘 | TONIUTTO P FABRIS C PIRISI M | 2006 | Expert Opin Pharmacother2006，7，15： | 1 |
| 7 | Assessment of liver fibrosis progression in patients with chronic hepatitis C and normal alanine aminotransferase values:the role of AST to the platelet ratio index显示文摘 | Fabris C Smime C Toniutto P | 2006 | Clin Biochem2006，39，4： | 1 |
| 8 | Genetic polymorphism at the apolipoprotein E locus affects the outcome of chronic hepatitis B 显示文摘 | Toniutto P Fattovich G Fabris C | 2010 | JMedVirol2010，82，2： | 1 |
| 9 | Sex-related influence of angiotensin-converting enzyme polymorphisms on fibrosis progression due to recurrent hepatitis C after liver transplantation显示文摘 | Fabris C Toniutto P Bitetto D | 2007 | J Gastroenterol2007，42，7： | 1 |
| 10 | Antiviral treatment of hepatitis C显示文摘 | Toniutto P Fabris C Pirisi M | 2006 | Expert Opinion on Pharmacotherapy2006，7，15： | 1 |
| 11 | Evaluation of donor hepatie iron concentration as a factor of early fibrotic progression after liver transplantation显示文摘 | Fabris C Bortolotti N | 2004 | J Hepatol2004，41，2： | 1 |
| 12 | Assessment of liver fi- brosis progression in patients with chronic hepatitis C nor- mal alanine aminotransferase values:The role of AST to the platelet ratio index 显示文摘 | Fabris C Smime C Toniutto P | 2006 | Clin Biochem2006，39，： | 1 |
| 13 | Antiviral treatment of hepatitis C 显示文摘 | TONIUTTO P FABRIS C PIRISI M | 2006 | Expert Opin Pharmaeother2006，7，15： | 1 |
| 14 | Favourable outcome of adefovir-dipivoxil treatment in acute de novo hepatitis B after liver transplantation 显示文摘 | TONIUTTO P FUMO E CALDATO M | 2004 | Transplantation2004，77，3： | 1 |
| 15 | Antiviral treatment of hepatitis C显示文摘 | TONIUTTO P FABRIS C PIRISI M | 2006 | Expert Opin Pharmacother2006，7，15： | 1 |
| 16 | Favourahle outcome of adefovir-dipivoxil treatment in acute de novo hepatitis B after liver transplantation 显示文摘 | Toniutto P Fumo Caldato M | 2004 | Transplantation2004，77，： | 1 |
| 17 | Genetic polymorphisms of inflammatory cytokines and liver fibrosis progression due to recurrent hepatitis C 显示文摘 | Falleti E Fabris C Toniutto P | 2007 | J Interferon Cytokine Res2007，27，3： | 1 |
| 18 | Antiviral treatment in pa- tients with hepatitis C virus-related cirrhosis awaiting liver trans- plantation显示文摘 | Toniutto P Fabris C Bitetto D | 2008 | Ther Clin Risk Mang2008，4，3： | 1 |
| 19 | MTHFR C677T polymorp- hism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption 显示文摘 | Fabiris C Toniutto P Falleti E | 2009 | Alcohol Clin Exp Res2009，33，1： | 1 |
| 20 | Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus显示文摘 | Toniutto P Fabris C Bitetto D | | 0，，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员