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| 1 | 非梗阻性无精子症患者的手术取精技术显示文摘卵细胞浆内单精子注射(ICSI)的发展开辟了辅助生殖技术的新领域,使男性不育的治疗发生了革命性的变化。除了自然的射精过程,经由生精小管获取的精子也能实现受精和妊娠。睾丸抽吸精子技术(TESA:针/细针抽吸)和睾丸切开取精术(TESE)被广泛应用于非梗阻性无精子症患者(NOA)获取精子的不育治疗当中。最理想的精子提取技术应尽可能地减少侵入性损伤和对睾丸功能的破坏,同时不影响获取足够数量的精子以行ICSI治疗。显微切割睾丸取精技术(micro—TESE)被广泛认为是有效获取NOA患者精子的最佳方法;其在手术显微镜下操作,非常容易辨认出较大的、透明度低的含有正常精曲小管的精子发生活跃区域。NOA患者行micro—TESE获取精子成功率较高,并且睾丸组织损伤最小,术后并发症发生较低。micro-TESE结合IcsI已经成为NOA患者(包括Klinefelter’s综合症患者)常规的辅助生殖方法。伴有血清卵泡刺激素(FSH)升高的NOA患者(包括KS患者)须结合精子缺乏的表型特征来评估外科取精的结果,还需分析手术获取精子的预测参数和治疗结果。最后,考虑用micro—TESE技术治疗NOA和KS患者(46XY)时的短期和长期并发症。 | Tomomoto Ishikawa | 2012 | Asian Journal of Andrology2012，14，1： | 23 |
| 2 | Assessment of availability of magnetic resonance angiography in renal arteriovenous fistula 显示文摘 | Tomomoto I Masato F Gaku K | 2004 | Urol Res2004，32，： | 1 |
| 3 | Assessment of a vailability of magenetic resonance angiography in renal arteriovenous fistula显示文摘 | TOMOMOTO I MASATO F GAK U K | | 0，，： | 1 |
| 4 | Cisplatin regulates sertoli cell expression of transferrin and interleukins 显示文摘 | KOHEI Y TOMOMOTO I YUTAKA K | 2007 | Molecular and Cellular Endocrinology2007，21，11： | 1 |
| 5 | Assessment of availability of magnetic resonance angiography in renal arteriovenous fistula显示文摘 | Tomomoto I Masato F Gaku K | 2004 | Urol Res2004，，32： | 1 |
| 6 | Assessment of gonadotropin therapy in male hypogonadotropic hypogonadism显示文摘 | Tomomoto Ishikawa Takeshi Ooba Yutaka Kondo Kohei Yamaguchi Masato Fujisawa | 2007 | Fertility and Sterility2007，，6： | 1 |
| 7 | Effect of BNT162b2 mRNA COVID-19 vaccine on sperm morphokinetics and DNA integrity: A prospective observational study in Japan显示文摘Objective:To assess whether the coronavirus disease 2019(COVID-19)mRNA vaccine affects sperm morphokinetics using a computer-assisted semen analyzer and other semen parameters using a sperm chromatin structure assay.Methods:Healthy male volunteers in two Japanese clinics between May 2021 and December 2021 were prospectively analyzed.Participants donated sperm twice,two days apart,in the following phases:before vaccination,2 weeks after the first vaccine dose,and 2,4,and 12 weeks after the second dose.Basic sperm parameters,sperm motility characteristics,and the percentage of DNA-damaged sperm were compared among the different phases.Results:Ninety-six semen samples from ten volunteers,who were vaccinated with the BNT162b2 mRNA vaccine,were evaluated.There were no significant differences between any phases in basic semen findings and parameters of the sperm chromatin structure assays.Regarding sperm motion characteristics,the average linear velocity,beat-cross frequency,and sperm motility index significantly decreased after the second vaccine dose(P=0.018,P=0.003,and P=0.027,respectively),with no significant differences between any two phases by post-hoc pairwise comparisons.Conclusions:After COVID-19 mRNA vaccination,while sperm motion characteristics might fluctuate,no apparent deterioration of basic sperm parameters or sperm DNA integrity was observed.Given the adverse effects of COVID-19 on sperm,our findings suggest that there might be no reason to refrain from vaccination for healthy individuals. | Yasuhiro Ohara Shimpei Mizuta Hidehiko Matsubayashi Tomomoto Ishikawa Tsuyoshi Takiuchi Tadashi Kimura | 2023 | Asian pacific Journal of Reproduction2023，12，2： | 0 |
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