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| 1 | Modern approach to cholecysto-choledocholithiasis显示文摘Gallstones and common bile duct calculi are found to be associated in 8%-20% of patients, leading to possible life-threatening complications, such as acute biliary pancreatitis, jaundice and cholangitis. The gold standard of care for gallbladder calculi and isolated common bile duct stones is represented by laparoscopic cholecystectomy and endoscopic retrograde cholangiopancreatography, respectively, while a debate still exists regarding how to treat the two diseases at the same time. Many therapeutic options are also available when the two conditions are associated, including many different types of treatment, which local professionals often administer. The need to limit maximum discomfort and risks for the patients, combined with the economic pressure of reducing costs and utilizing resources, favors single-step procedures. However, a multitude of data fail to strongly demonstrate the superiority of any technique(including a two or multi-step approach), while rigorous clinical trials that include so many different types of treatment are still lacking, and it is most likely unrealistic to conduct them in the future. Therefore, the choice of the best management is often led by the local presence of professional expertise and resources, rather than by a real superiority of one strategy over another. | Lapo Bencini Cinzia Tommasi Roberto Manetti Marco Farsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 28 |
| 2 | H pylori status and angiogenesis factors in human gastric carcinoma显示文摘AIM: To investigate H pylori expression in gastric cancer patients in relation to primary tumor angiogenic markers, such as microvessel density (MVD), thymidine phospho- rylase (TP), vascular endothelial growth factor receptor-1 (VEGF-R1), p53 and circulating VEGF levels. METHODS: Angiogenic markers were analyzed immu- nohistochemically in 56 primary gastric cancers. H pylori cytotoxin (vacA) and the cytotoxin-associated gene (cagA) amplification were evaluated using PCR assay. Serum H pylori IgG antibodies and serum/plasma circulating VEGF levels were detected in 39 and 38 patients by ELI- SA, respectively. RESULTS: A total of 69% of patients were positive for circulating IgG antibodies against H pylori. cagA-positive H pylori strains were found in 41% of gastric patients. vacA was found in 50% of patients; s1 strains were more highly expressed among vacA-positive patients. The presence of the s1 strain was signifi cantly associ- ated with cagA (P = 0.0001). MVD was signifi cantly cor- related with both tumor VEGF expression (r = 0.361, P = 0.009) and serum VEGF levels (r = -0.347, P = 0.041).Conversely, neither VEGF-R1 expression nor MVD was related to p53 expression. However, H pylori was not related to any angiogenic markers except for the plasma VEGF level (P = 0.026). CONCLUSION: H pylori antigen is related to higher plasma VEGF levels, but not to angiogenic character- istics. It can be hypothesized that the toxic effects of H pylori on angiogenesis occurs in early preclinical dis- ease phase or in long-lasting aggressive infections, but only when high H pylori IgG levels are persistent. | Anita Mangia Annalisa Chiriatti Girolamo Ranieri Ines Abbate Maria Coviello Giovanni Simone Francesco Alfredo Zito Severino Montemurro Antonello Rucci Alfredo Di Leo Stefania Tommasi Pasquale Berloco Jian Ming Xu Angelo Paradiso | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 3 | Epigenetics of human melanoma: promises and challenges显示文摘黑瘤是有升起的发生和死亡率的皮肤癌症的最致命的形式。尽管早阶段的黑瘤是高度可医好的,先进阶段的黑瘤对治疗倔强。这象需要一样强调预防和早察觉的重要性改进人的黑瘤的治疗和预知。人的黑瘤罐头帮助的开始和前进的阐明的位于这疾病的预防,诊断,治疗,和预后下面机制为识别干预的潜在的目标。异常 DNA methylation 和 histone 修正是 carcinogenesis 的建立最好的 epigenetic 机制。epigenetic 的出现通过途径为关于人的黑瘤的基本、翻译的研究为一条有希望的大街提供的 pharmacologic/genetic 在癌症和他们的可逆性的临床的诊断以前变化。候选人基因或染色体宽的异常 DNA methylation 和 histone 修正在人的黑瘤肿瘤纸巾和房间线被观察了,并且相关到细胞、功能的特征或这恶意的 clinicopathological 特征。现在的评论与人的黑瘤相关在异常 DNA methylation 和 histone 修正上总结出版研究。代表性的研究被加亮在研究的这些 epigenetic 领域里提出知识,在 knowledgebase 的差距,和未来方向的当前的状态。epigenetic 治疗的例子在 vitro,和挑战申请了人的黑瘤它的在里面为稳固的肿瘤的临床的治疗的 vivo 申请被讨论。 | Ahmad Besaratinia Stella Tommasi | 2014 | Journal of Molecular Cell Biology2014，8，5： | 2 |
| 4 | Granulocyle/macrophage colonystimulating factor treatment of human chronic ulcers promotes angiogenesis associated with de novo vascular endothelial growth factor transcription in the ulcer bed显示文摘 | Cianfarani F Tommasi R Failla CM | 2006 | Br J Dcrmatol2006，154，1： | 1 |
| 5 | Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A)in malignant cutaneous melanoma显示文摘 | Spugnardi M Tommasi S Dammann R | | Cancer Res0，63，7： | 1 |
| 6 | Antioxidant principles from Bauhinia tarapotensis显示文摘 | BRACA A DE TOMMASI N DI BARI L | 2001 | j Nat Prod2001，，64： | 1 |
| 7 | The antioxidant systems vis-a-vis reactive oxygen species during plant-pathogen inter action显示文摘 | De Gara L de Pinto M C Tommasi F | 2003 | Plant Physiology and Biochemistry2003，41，10： | 1 |
| 8 | Central neurocytoma:two case reports and review of the literature显示文摘 | Tommasi A D'Urso P Tommasi C | 2006 | Neurosurg Rev2006，29，6： | 1 |
| 9 | Antioxidant principles from Bauhinia terapotensis显示文摘 | Braca A Tommasi N D Bari L D | 2001 | Journal Of Natural Products2001，64，： | 1 |
| 10 | A dynamic wind farm aggregate model for the simulation of power fluctuations due to wind turbulence显示文摘 | Tommasi L D Gibescu M Brand A J | 2010 | Journal of Computational Science2010，1，2： | 1 |
| 11 | On K-diegnosiability of Petri nets via integer linear programming显示文摘 | Basile F Chiacchio P De Tommasi G | 2012 | Automatics2012，，48： | 1 |
| 12 | Granulocyte/macrophage colony-stimu-lating factor treatment of human chromic ulcers promotes angiogenesis associated with de novo vascular endothelial growth faeeor transcription in the ulcer bed显示文摘 | Cianfarani F Tommasi R Failla CM | 2006 | Br J Dermatol2006，154，1： | 1 |
| 13 | RASSF proteins显示文摘 | Pfeifer G P Dammann R Tommasi S | 2010 | Curr Biol2010，20，8： | 1 |
| 14 | Antioxidant principles from Bauhinia terapotensis显示文摘 | BRACA A TOMMASI N D DIBARIL L | | 0，，： | 1 |
| 15 | The dark side of the moon: The PI3K/PTEN/AKT pathway in colorectal carcinoma 显示文摘 | Silvestfis N Tommasi S Petfiella D | 2009 | Oncol2009，77，1： | 1 |
| 16 | Triterpenoids saponins from Pteleopsis suberosa stem bark 显示文摘 | Leo M D Tommasi N D Sanogo R | 2006 | Phytochemistry2006，67，： | 1 |
| 17 | In vitro propagation of Ginkgo biloba by using various bud cultures显示文摘 | F Tommasi F ScaramuZzi | 2004 | Biologia plantarum2004，48，2： | 1 |
| 18 | Control of microtubule stability by the RASSF1A tumor suppressor显示文摘 | Liu L Tommasi S Lee DH | 2003 | Oncogene2003，22，50： | 1 |
| 19 | Modem approach to cho- lecysto-choledocholithiasis 显示文摘 | Bencini L Tommasi C Manetti R | 2014 | World J Gastrointest Endosc2014，6，2： | 1 |
| 20 | RASSF3 and NORE1:identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1显示文摘 | Tommasi S Dammann R Jin SG | 2002 | Oncogene2002，21，17： | 1 |
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