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	题名	作者	年代	出处	被引量
1	Hepatocyte transplantation program:Lessons learned andfuture strategies显示文摘This review aims to share the lessons we learned over time during the setting of the hepatocyte transplantation(HT) program at the Hepatic Cell Therapy Unit at Hospital La Fe in Valencia. New sources of liver tissue for hepatocyte isolation have been explored. The hepatocyte isolation and cryopreservation procedures have been optimized and quality criteria for assessment of functionality of hepatocyte preparations and suitability for HT have been established. The results indicate that:(1) Only highly viable and functional hepatocytes allow to recover those functions lacking in the native liver;(2) Organs with steatosis(≥ 40%) and from elderly donors are declined since low hepatocyte yields, viability and cell survival after cryopreservation, are obtained;(3) Neonatal hepatocytes are cryopreserved without significant loss of viability or function representing high-quality cells to improve human HT;(4) Cryopreservation has the advantage of providing hepatocytes constantly available and of allowing the quality evaluation and suitability for transplantation; and(5) Our results from 5 adults with acute liver failure and 4 from children with inborn metabolic diseases, indicate that HT could be a veryuseful and safe cell therapy, as long as viable and metabolically functional human hepatocytes are used.	Eugenia Pareja Ibars Miriam Cortes Laia Tolosa Maria JoséGómez-Lechón Slivia López JoséVicente Castell JoséMir	2016	World Journal of Gastroenterology2016，22，2：	3
2	Dual-labeled glucose binding protein for ratiometric measurements of glucose显示文摘	GE Xudong TOLOSA L RAO Govind	2004	Anal Chem2004，76，：	1
3	IFN-γ prevents TNF-α-induced apoptosis in C2C12 myotubes through down-regulation of TNF-R2 and increased NF-κB activity显示文摘	Tolosa L Morla M Igles ias A	2005	Cellular Signalling2005，17，11：	1
4	Dual-labeled gulucose binding proterin for ratiometric measurements of glucose显示文摘	Ge X D Tolosa L Rao G	2004	Anal Chem2004，76，5：	1
5	Complementary roles of tumor necrosis factor alpha and interferon gamma in inducible microglial nitric oxide generation 显示文摘	Mir M Tolosa L Asensio V J	2008	J Neuroimmunol2008，204，12：	1
6	Genetically engineered binding proteins as biosensors for fermentation and cell culture显示文摘	Ge X Tolosa L Simpson J	2003	Biotechnol Bioeng2003，84，6：	1
7	Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs 显示文摘	Tolosa L Pinto S Donato Mr Ioz A Castell JV O'Connor JE	2012	Toxicol Sci2012，127，1：	1
8	Statistics as support tool and not as a decision tool 显示文摘	Fernandez Perez C Barreales Tolosa L Coil Tones E	2003	Arch Esp Urol2003，56，6：	1
9	Comparison of the performance of solid - phase extraction techniques in the recovering organophosphrous and organochlorine compounds from water显示文摘	Tolosa I Readman J W Mee L D	1996	Chromatogr1996，725，1：	1
10	Diagnostic validity of helical CT compared to ultrasonography in renal-ureteral colic显示文摘	Rcngifo Abbad D Rodriguez Caravaca G Barreales Tolosa L	2010	Arch Esp Urol2010，63，2：	1
11	Diagnostic validity of helical CT compared to uhrasonography in renal-ureteral colic 显示文摘	Rengifo Abbad D Rodriguez Caravaca G Barreales Tolosa L	2010	Arch Esp Urol2010，63，2：	1
12	Vascular endotheli- al growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase 显示文摘	Tolosa L Mir M Asensio V J	2008	J N eurochem2008，105，4：	1
13	Comparison of the Performance of Solid-phase Extraction Techniques in Recovering Organophosphorus and Organochlorine Compounds from Water显示文摘	Tolosa I Readman J W Mee L D	1996	J Chromatogr A1996，，725：	1
14	Comparsion of the performance of solid-phase extraction techniques in recovering organophosphrous and organochlorine compounds from water显示文摘	Tolosa I Readman J W Mee L D	1996	Chromatogaphy1996，725，1：	1
15	Genetically engineered binding proteins as biosensors for fermentation and cell culture 显示文摘	Ge X Tolosa L Simpson J	2003	Biotechnol Bioeng2003，84，6：	1
16	Vascular endothelial growth factor pro- tects spinal cord motoneurons against glutamate-induced exeitotoxicity via phosphatidylinositol 3-kinase 显示文摘	Tolosa L Mir M Asensio VJ	2008	J Neurochem2008，105，4：	1
17	Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population 显示文摘	Garcia Rodriguez LA Barreales Tolosa L	2007	Gastroenterology2007，132，2：	1
18	Upgra- ding cytochrome P450 activity in HepG2 cells co - transfected with adenoviral vectors for drug hepatotox- icity assessment 显示文摘	Tolosa L Donato M T Prrez - Cataldo G	2012	Toxicology in Vitro2012，26，8：	1
19	Consumer preferencesand willingness to pay for organic apples in Santiago MetropolitanRegion, Chile显示文摘	CERDA A A GARCIA L Y TOLOSA F J	2014	Revista de la facultad de Agronomia de la uni-versidad del zulia2014，31，2：	1
20	Combined effects of formulation and stirring on emulsion drop size in the vicinity of three - phase behavior of surfactant - oil water systems 显示文摘	TOLOSA L I FORGIARINI A MORENO P	2006	Ind Eng Chem Res2006，45，：	1

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