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| 1 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 2 | IFN-γ prevents TNF-α-induced apoptosis in C2C12 myotubes through down-regulation of TNF-R2 and increased NF-κB activity显示文摘 | Tolosa L Morla M Igles ias A | 2005 | Cellular Signalling2005，17，11： | 1 |
| 3 | The clinical and pathophysio-logical relevance of REM sleep behavior disorder in neurodege-nerative diseases显示文摘 | Iranzo A Santamaria J Tolosa E | | 0，，06： | 1 |
| 4 | Insulin-deficient diabetes-induced bone microarchitecture alterations are associated with a decrease in the osteogenic potential of bone marrow progenitor cells: Preventive effects of metformin显示文摘 | María José Tolosa Sara Rocío Chuguransky Claudia Sedlinsky León Schurman Antonio Desmond McCarthy María Silvina Molinuevo Ana María Cortizo | 2013 | Diabetes Research and Clinical Practice2013，，2： | 1 |
| 5 | Muh-i element analysis of road deposited sediment in an urban drainage basin,Honolulu,Hawaii显示文摘 | SUTHERLAND R A TOLOSA C A | 2000 | Environmental Pollution2000，110，3： | 1 |
| 6 | Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study显示文摘 | Iranzo A Tolosa E Gelpi E | 2013 | Lancet Neurol2013，12，5： | 1 |
| 7 | The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases显示文摘 | Iranzo A Santamaria J Tolosa E | 2009 | Sleep Med Rev2009，13，6： | 1 |
| 8 | Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder:an observational cohort study显示文摘 | Iranzo A Tolosa E Gelpi E | | 0，，05： | 1 |
| 9 | Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats显示文摘 | Claudia Sedlinsky María Silvina Molinuevo Ana María Cortizo María José Tolosa Juan Ignacio Felice María Laura Sbaraglini Leon Schurman Antonio Desmond McCarthy | 2011 | European Journal of Pharmacology2011，，3： | 1 |
| 10 | Evaluation of neuronal loss,astrocytosis and abnormalities of cytoskeletal components of large motor neurons in the human anterior horn in aging显示文摘 | Cruz-Sánchez F F Moral A Tolosa E | | 0，，6： | 1 |
| 11 | Multi - element maalysis of road - deposited sediment in an urban drainage basin Honolulu Hawaii显示文摘 | Sutherland R A Tolosa CA | 2000 | Environmental Pollution2000，110，： | 1 |
| 12 | Character- ization of selected element concentrations and enrichment ratios in background and anthropogenic ally impacted road- side areas 显示文摘 | Sutherland R A Tolosa C A Tack F M G | 2000 | Archives of Environmental Contamination and Toxicology2000，38，4： | 1 |
| 13 | Development of photoluminescent powder coatings by UV curing process显示文摘 | ALCON N TOLOSA A RODRIGUEZ M T | 2010 | Progress in Organ c Coatings2010，68，12： | 1 |
| 14 | Chronic renal disease in pregnancy:a modem approach to predicting outcome显示文摘 | Modena A Hoffman M Tolosa JE | 2005 | Am J Obstet Gynecol2005，2，7： | 1 |
| 15 | The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases显示文摘 | Iranzo A Santamaria J Tolosa E | 2009 | Sleep Med Rev2009，13，： | 1 |
| 16 | Diagnosis and the premotor phase of Parkinson disease显示文摘 | Tolosa E Gaig C Santamaría J | 2009 | Neurology2009，72，7： | 1 |
| 17 | Bilateral subthalamic nucleus lesion reverses L-dopa-induced motor fluctuations and facilitates dyskinetic movements in hemiparkinsonian rats显示文摘 | Marin C JimOnez A Tolosa E | 2004 | Synapse2004，51，： | 1 |
| 18 | Multi-element analysis of road-deposi- ted sediment in urban drainage basin, Honolulu, Hawaii 显示文摘 | Sutherland R A Tolosa C A | 2000 | Envi- ronment Pollution2000，110，： | 1 |
| 19 | Variation in total and extractable elements with distance from roads in and urban watershed, Honolulu, Hawaii显示文摘 | Sutherland R A Tolosa C A | 2001 | Water Air Soil Pollut2001，127，： | 1 |
| 20 | Multi-element analysis of road-deposited sediment in an urban drainage basin,Honolulu,Hawaii显示文摘 | Sutherland R A Tolosa C A | 2000 | Environmental pollution2000，110，3： | 1 |
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