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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Over-expression of the MTA1 gene in gastrointestinal carcinomas:correlation with invasion and metastasis 显示文摘 | Toh Y Oki E Oda S | 1997 | Int J Cancer1997，74，4： | 1 |
| 3 | Overexpression of the mtalgene in gastrointestina lcarcinomas:correlation with invasion and metastasis显示文摘 | Toh Y Oki E Oda S | 1997 | Int J Cancer1997，74，4： | 1 |
| 4 | Analysis of the complete sequence of the novel metastasis associated candidate gene, mtal, differentially expressed in mammary adenocarcinoma and breast cancer cell lines显示文摘 | Pencil SD Nicolson GL | 1995 | Gene1995，159，1： | 1 |
| 5 | Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation显示文摘 | NICOLSON G L NAWA A TOH Y | 2003 | Clin Exp Metastasis2003，20，： | 1 |
| 6 | Fabrication and characterization of anatase/rutile-TiO2 thin films by magnetron sputtering:a review显示文摘 | TANEMURA S MIAOA L WUNDERLICH W TANEMURA MASAKI MORI Y TOH S KANEKO K | 2005 | Science and Technology of Advanced Materials2005，，6： | 1 |
| 7 | The role of the MTA family and their encoded proteins in human cancets:molecular functions and clinical implica- tions 显示文摘 | Toh Y Nicolson G L | 2010 | Clin Exp Metastasis2010，26，3： | 1 |
| 8 | Candidate metastasis associ- ated genes of the rat 13762NF mammary adenocarcinoma 显示文摘 | Pencil SD Toh Y Nicolson GL | 1993 | Breast Cancer Res Treat1993，25，2： | 1 |
| 9 | High organic loading influences the physical characteristics of aerobic granules显示文摘 | Moy B Y P Tay J H Toh S K | 2002 | Letters in Applied Microbiology2002，34，： | 1 |
| 10 | Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinoma显示文摘 | Toh Y Ohga T Endo K | 2004 | Int J Cancer2004，110，： | 1 |
| 11 | A novel candidate metastasisassociated gene, total, differentially expressed in highly metastatic mammary adenocarcinoma cell lines, cDNA cloning, expression,and protein analyses显示文摘 | Toh Y Pencil SD Nicolson GL | 1994 | J Biol Chem1994，269，22： | 1 |
| 12 | A novel candidate metasta- sis- associate gene, mtal, differentially expressed in highly metastatic mammary adenocarcinoma cell lines 显示文摘 | Toh Y Pencil S D Nicolson GL | 1994 | Biol Chem1994，269，22： | 1 |
| 13 | Noblp is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saecha- romyces cerevisiae显示文摘 | Tone Y Toh EA | 2002 | Genes Dev2002，16，24： | 1 |
| 14 | Candidate metastasis-associated genes of the rat 13762NF mammary adenocarcinoma显示文摘 | PENCIL SD TOH Y NICOLSON GL | 1993 | Breast Cancer Res Treat1993，25，2： | 1 |
| 15 | Expression of mitogen-activated protein kinase phosphatase 1,a negative regulator of the mitogen-activated protein kinases,in rheumatoid arthritis up-regulation by interleukin-1 beta and glucocorticoids显示文摘 | Toh ML Yang Y Leech M | 2004 | Arthritis Rheum2004，50，10： | 1 |
| 16 | Overexpression of the MTA1 gene in gastrointestinal carcinomas: corre lation with invasion and metastasis显示文摘 | TOH Y OKI E ODA S | 1997 | Int J Cancer1997，74，： | 1 |
| 17 | High organic loadinginfluences the physical characteristics of aerobic sludge granules显示文摘 | Moy B Y P Tang J H Toh S K | 2002 | Letters Applied Microbiology2002，34，6： | 1 |
| 18 | Candidate metastasis-associated genes of the rat 13762NF mammary adenocarcinoma显示文摘 | Pencil SD Toh Y Nicolson GL | 1993 | Breast Cancer Res Treat1993，25，2： | 1 |
| 19 | TCP-BuS:Improving TCP performance in wireless Ad Hoc networks显示文摘 | Kim D Toh C K Choi Y | 2001 | Journal of Communications and Networks2001，3，2： | 1 |
| 20 | Analysis of the complete se- quence of the novel metastasis- associated candidate gene, rata l, differentially expressed in mammary adenocarcinoma and breast cancer cell lines 显示文摘 | Toh Y Oki E Oda S | 1995 | Gene1995，159，1： | 1 |
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