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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Dust-storm source areas determined by the total ozone monitoring spectrometer and surface observations显示文摘 | Washington R Todd M Middleton N J | 2003 | Annals of the Association of American Geographers2003，93，2： | 1 |
| 3 | Relationship between wear rate,surface pullout and microstructure during abrasive wear of alumina and alumina/SiC nanocomposites显示文摘 | MERINO J O L TODD R I | 2005 | Acta Materialia2005，53，12： | 1 |
| 4 | Performance characteristics for the quantitation of plasma HIV-1 RNA using branched DNA signal amplification technology 显示文摘 | Todd J Pachl C White R | 1995 | J Acquir Immune Defic Syndr Hum Retrovirol1995，10，2： | 1 |
| 5 | Selective electrodeposition of metal from simulated waste solutions 显示文摘 | Armstrong R D Todd M Atkinson J W | 1996 | Applied Electrochem1996，26，： | 1 |
| 6 | Transgenic soybeans expressing siRNAs specific to a major sperm protein gene suppress Heterodera glycines reproduction 显示文摘 | Steeves R M Todd T C Essig J S | 2006 | Functional Plant Biology2006，33，： | 1 |
| 7 | The antifouling activity of natural and synthetic phenolic acid sulphate eaters显示文摘 | Todd J T Zimmerman R C Crews P | 1993 | Phytochemistry1993，34，2： | 1 |
| 8 | Cesium sorption from concentrated acidic tank wastes using ammonium mo- lybdophosphate-polyacrylonitrile composite sorbents显示文摘 | Todd T A Mann N R Traner T J | 2002 | J Radioanal Nucl Chem2002，254，1： | 1 |
| 9 | Tin-transition metal-carbon systems for lithium-ion battery negative electrodes显示文摘 | Todd A D W Mar R E Dahn J R | 2007 | Journal of the Electrochemical Society2007，154，6： | 1 |
| 10 | Developmental changes in aural acoustic admittance measurements显示文摘 | De Chicchis AR Todd NW Nozza R J | 2000 | J Am Acad Audiol2000，11，： | 1 |
| 11 | The development, testing, and application of a numerical simulator for predicting miscible flood performance显示文摘 | Todd M R Longstaff W J | 1972 | Journal of Petroleum Technology1972，24，7： | 1 |
| 12 | Using the Monte Carlo-Library Least-Squares (MCLLS) approach for the invivo XRF measurement of lead in bone显示文摘 | Guo W J Gardner R P Todd A C | 2004 | Nuclear Instruments and Methods in Physics Research A2004，516，23： | 1 |
| 13 | Back to Our Beginning: Information Utilization, Bertram Brookes and the Fundamental Equation of Information Science显示文摘 | TODD R J | 1999 | Information Processing and Management1999，35，6： | 1 |
| 14 | Evaluation of candidate vaccine approaches for mers-cov显示文摘 | Wang L Shi W Joyce M G Modjarrad K Zhang Y Leung K Lees C R Zhou T Yassine H M KanekiyoM Yang Z Y Chen X Becker M M Freeman M Vogel L Johnson J C Olinger G Todd J P Bagci U Solomon J Mollura D J Hensley L Jahrling P Deni- son M R Rao S S Subbarao K Kwong P D Mascola J R Kong W P Graham B S | 2015 | Nat Commun2015，6，： | 1 |
| 15 | Combinatorial study of tin-transition metal alloys as negative electrodes for lithiumion batteries显示文摘 | Todd A D W Mar R E Dahn J R | 2006 | J Electrochem Soc2006，153，10： | 1 |
| 16 | Methods for increased accuracy in numerical reservoir simulators显示文摘 | M R Todd P M O'dell G J Hirasaki | 1972 | Soc Petrol Engry J1972，，12： | 1 |
| 17 | On the nesterov-todd direction in semidefinite programming显示文摘 | Todd M J Toh K C Tutuncu R H | 1998 | SIAM J Optim1998，8，： | 1 |
| 18 | Deleted in oral cancer-1 (doc-1),a novel oral tumor suppressor gene显示文摘 | TODD R MCBRIDE J TSUJI T | 1995 | FASEB J1995，9，： | 1 |
| 19 | Deleted in oral cancer-1 (doc-1), a novel oral tumor suppressor gene显示文摘 | Todd R McBride J Tsuji T | 1995 | FASEB J1995，9，13： | 1 |
| 20 | Increased Sensi- tivity of the Rapid Hydrophobic Grid Membrane Filter Enzyme- Labeled Antibody Procedure for Eschcrichia coli O157 Detection in Foods and Bovine Feces显示文摘 | Szabo R A Todd E C D Mackenzie J M | 1990 | Applied and Environmental Mi- crobiology1990，56，11： | 1 |
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