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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | A Generic Workflow for the Data FAIRification Process显示文摘The FAIR guiding principles aim to enhance the Findability,Accessibility,Interoperability and Reusability of digital resources such as data,for both humans and machines.The process of making data FAIR(“FAIRification”)can be described in multiple steps.In this paper,we describe a generic step-by-step FAIRification workflow to be performed in a multidisciplinary team guided by FAIR data stewards.The FAIRification workflow should be applicable to any type of data and has been developed and used for“Bring Your Own Data”(BYOD)workshops,as well as for the FAIRification of e.g.,rare diseases resources.The steps are:1)identify the FAIRification objective,2)analyze data,3)analyze metadata,4)define semantic model for data(4a)and metadata(4b),5)make data(5a)and metadata(5b)linkable,6)host FAIR data,and 7)assess FAIR data.For each step we describe how the data are processed,what expertise is required,which procedures and tools can be used,and which FAIR principles they relate to. | Annika Jacobsen Rajaram Kaliyaperumal Luiz Olavo Bonino da Silva Santos Barend Mons Erik Schultes Marco Roos Mark Thompson | 2020 | Data Intelligence2020，2，1： | 5 |
| 3 | The“A”of FAIR-As Open as Possible,as Closed as Necessary显示文摘In order to provide responsible access to health data by reconciling benefits of data sharing with privacy rights and ethical and regulatory requirements,Findable,Accessible,Interoperable and Reusable(FAIR)metadata should be developed.According to the H2020 Program Guidelines on FAIR Data,data should be'as open as possible and as closed as necessary','open'in order to foster the reusability and to accelerate research,but at the same time they should be'closed'to safeguard the privacy of the subjects.Additional provisions on the protection of natural persons with regard to the processing of personal data have been endorsed by the European General Data Protection Regulation(GDPR),Reg(EU)2016/679,that came into force in May 2018.This work aims to solve accessibility problems related to the protection of personal data in the digital era and to achieve a responsible access to and responsible use of health data.We strongly suggest associating each data set with FAIR metadata describing both the type of data collected and the accessibility conditions by considering data protection obligations and ethical and regulatory requirements.Finally,an existing FAIR infrastructure component has been used as an example to explain how FAIR metadata could facilitate data sharing while ensuring protection of individuals. | Annalisa Landi Mark Thompson Viviana Giannuzzi Fedele Bonifazi Ignasi Labastida Luiz Olavo Bonino da Silva Santos Marco Roos | 2020 | Data Intelligence2020，2，1： | 4 |
| 4 | Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor positive breast carcinoma cell line显示文摘 | Kuang WW Thompson DA Hoch RV | | 0，，： | 2 |
| 5 | Functional bowel disorders and functional abdominal pain 显示文摘 | Thompson WG Longstreth GF Drossman DA | 1999 | Gut1999，45，： | 1 |
| 6 | Functional bowel disorders and function abdominal pain 显示文摘 | Thompson WG Creed F Drossman DA | 1992 | Gastroenterol Int1992，，5： | 1 |
| 7 | Reviews of evidence re- garding interventions to increase use of child safety seats 显示文摘 | Zaza S Sleet DA Thompson RS | 2001 | Am J Prev Med2001，21，4： | 1 |
| 8 | Functional bowel disorders and functional abdominal pain显示文摘 | Thompson WG Longstreth GF Drossman DA et a l | 1999 | Gut1999，45，1： | 1 |
| 9 | Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis显示文摘 | Jones DL Thompson DA Munger K | | 0，，： | 1 |
| 10 | Transrectal biopsy of the prostate and bacteraemia显示文摘 | Thompson PM Talbot RW Packham DA | 1980 | Br J Surg1980，67，： | 1 |
| 11 | Functional bowel disorders and functional abdominal pain显示文摘 | Thompson WG Longstreth GF Drossman DA | 1999 | Gut1999，45，： | 1 |
| 12 | Functional bowel disor ders and functional abdominal pain显示文摘 | Thompson WG Longstreth GF Drossman DA | 1999 | Gut1999，45，2： | 1 |
| 13 | Functional bowel disorders and functional abdominal pain显示文摘 | Thompson WG Longstreth GF Drossman DA etal | 1999 | Gut1999，45，2： | 1 |
| 14 | Functional bowel disorders and functional abdominal pain显示文摘 | Thompson WG Longstreth GF Drossman DA | 1999 | Gut1999，45，2： | 1 |
| 15 | Functional bowel disorders and functional abdominal pain显示文摘 | Thompson WG Longstreth GF Drossman DA | 1999 | Gut1999，45，2： | 1 |
| 16 | Functional bowel disorders and function abdominal pain 显示文摘 | Thompson WG Creed F Drossman DA | 1992 | Gastroenterol Int1992，5，3： | 1 |
| 17 | Collaborative cohort study of an intervention to reduce ventilator-associated pneumonia in the intensive care unit显示文摘 | Berenholtz SM Phan JC Thompson DA | 2011 | Infect Control Hosp Epidemiol2011，32，4： | 1 |
| 18 | Case-based or non-casebased questions for teaching postgraduate physicians:a randomized crossover trial显示文摘 | Cook DA Thompson WG Thomas KG | 2009 | Acad Med2009，84，10： | 1 |
| 19 | Functional bowel disorders and functional abdominal paln显示文摘 | Thompson WG Longstreth GF Drossman DA | 1999 | Gut1999，45，： | 1 |
| 20 | Functional bowel disorders and functional abdominal pain显示文摘 | Thompson WG Longstreth GF Drossman DA | 1999 | Gut1999，45，2： | 1 |
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