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| 1 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 2 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 3 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 4 | Mechanisms of formation damage and permeability impairment associated with the drilling,completion and production of low API gravity oil reservoirs显示文摘 | Thomas F B Bennion D W | 1996 | SPE 303201996，，： | 1 |
| 5 | Registration of LD00- 2817P soybean germplasm line with resistance to soybean cyst nematode from PI 437654 显示文摘 | Diets B W Cary T Thomas D | 2010 | Journal of Plant Registrations2010，4，2： | 1 |
| 6 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 7 | Improving the nutritive value of full-fat rice bran for broiler chickens using a lipase-basedenzyme preparation显示文摘 | Tan S H Thomas D V Cumden B Je t al | 2000 | Asian Australasian Journal of Animal Sciences2000，13，3： | 1 |
| 8 | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase 显示文摘 | Thoma R Schulz-Gasch T D'Arcy B | 2004 | Nature2004，432，7013： | 1 |
| 9 | A phenyl-thiadiazolyli- dene-amine derivative ejects zinc from retroviral nuc-leo- capsid zinc fingers and inactivates HIV virions 显示文摘 | Thomas V Beata B Wim D | 2012 | Retro- virology2012，95，： | 1 |
| 10 | Gaussian random number generators显示文摘 | Thomas D B Luk W Leong P H W etal | 2007 | ACM Computing Surveys2007，39，4： | 1 |
| 11 | Application of heat treatment to enhance permeability in tight gas reservoirs显示文摘 | Jamaluddin A K M Bennion D B Thomas F B | 2000 | JCPT2000，39，11： | 1 |
| 12 | Reductions in the productivity of oil and low permeability gas reservoirs due to aque- ous phase trapping 显示文摘 | Bennion D B Bietz R F Thomas F B | 1994 | Journal of Crgstallization Process and Tech- nology1994，33，8： | 1 |
| 13 | Numerical study of steady turbulent flow through bifurcated nozzles in continu- ous casting显示文摘 | Najjar F Thomas B Hershey D | 1995 | Metall Mater Trans B1995，26，4： | 1 |
| 14 | Modeling chloride diffu- sion in concrete:effect of fly ash and slag显示文摘 | THOMAS M D A BAMFORTH P B | 1999 | Cement and Con- crete Research1999，29，4： | 1 |
| 15 | Modeling chloride diffusion in concrete effect of fly ash and slag 显示文摘 | Thomas M D A and Bamforth P B | 1999 | Cement and Concrete Research1999，，29： | 1 |
| 16 | Collapsing glomerulopathy associ ated with inherited mitochondriai injury显示文摘 | Barisoni L Diomedi-Camassei F Santorelli F M Caridi G Thomas D B Emma F | 2008 | Kidney Int2008，74，： | 1 |
| 17 | A trypsin-solubilized laccase from pharate pupal integument of the tobacco homworm, Manduca sexta 显示文摘 | Thomas B R Yonekura M Morgan T D | 1989 | Insect Biochem1989，19，7： | 1 |
| 18 | EPOS Primary Care Guidelines: European Position Paper on the Primary Care Diagnosis and Manage- ment of Rhinosinusitis and Nasal Polyps 2007-a summary 显示文摘 | Thomas M Yawn B Price D | 2008 | Prim Care Respir J2008，17，2： | 1 |
| 19 | The Determination of the Plate Count for Large Molecules under Reversed-Phase Gradient Conditions显示文摘 | Uwe D N Hillary B H Thomas E W | 2010 | Journal of Chromatography A2010，1217，14： | 1 |
| 20 | Successive emergence of extended-spectrum beta-lactamase-producing and carbapenemase-pro- dueing Enterobacter aerogenes isolates in a university hospital 显示文摘 | Biendo M Canarelli B Thomas D | 2008 | J Clin Microbiol2008，46，3： | 1 |
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