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| 1 | A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response显示文摘病毒的 RNA 的识别由 cytosolic 传感器 retinoic 组织酸可诱导的基因 --(RIG-I ) 我导致表明与类型的产生达到顶点的串联的激活我干扰素(IFN ) 抗病毒的反应。对病毒的病原体的抗病毒、煽动性的回答的发作要求表明改编者, kinases 和 transcriptional 蛋白质到 mitochondrial 的调整空间与时间的招募抗病毒的发信号蛋白质(MAVS ) 。我们以前示威了 serine/threonine kinase IKKε被招募到 MAVS 后面的仙台或小囊的口炎病毒(VSV ) 感染的 C 终端区域,在 Lys500 由 MAVS 的连接 Lys63 的 polyubiquitination 调停了,导致下游的 IFN 发信号的抑制(Paz 等,摩尔房间 Biol, 2009 ) 。在这研究,我们证明 MAVS 的 C 终点在 MAVS 的 aa450-468 区域怀有一个新奇 TRAF3 有约束力的地点。一个一致交往 TRAF 主题(提姆) , 455-PEENEY-460,在这以内,地点为 TRAF3 绑定和 IFN 抗病毒的反应基因的激活被要求,而 TIM 的变化消除 TRAF3 绑定和下游的 IFN 反应。有表示 MAVS 的一个变异提姆的版本的构造的 MAVS −/− 老鼠胚胎成纤维细胞的宪法没能恢复抗病毒的反应或块 VSV 复制,而野类型的 MAVS 重新组成 VSV 复制的抗病毒的抑制。而且, IKKε 的招募;到在经由 Lys500 的 MAVS 的一个邻近的 C 终端地点(aa 468-540 ) , ubiquitination 减少了 TRAF3 绑定和蛋白质稳定性,因此贡献 IKKε调停 IFN 反应关机。这研究证明 MAVS 怀有功能的 C 终端参予 IFN 抗病毒的反应的积极、否定的规定的 TRAF3 有约束力的地点。 | Suzanne Paz Myriam Vilasco Steven J Werden Meztli Arguello Deshanthe Joseph-Pillai Tiejun Zhao Thi Lien-Anh Nguyen Qiang Sun Eliane F Meurs Rongtuan Lin John Hiscott | 2011 | Cell Research2011，21，6： | 12 |
| 2 | Effect of omega - 3 fatty acid sup- plementation on markers of platelet and endothelial function in patients with peripheral arterial disease 显示文摘 | Mackay I Ford I Thies F | 2012 | Atherosclerosis2012，221，2： | 1 |
| 3 | Dietary supplemention with gamma-linolenic acid or fish oil decrease T lymphocyte proliferation in healthy older humans显示文摘 | Thies F Nebe-von-Caron G Powell JR | 2001 | J Nutr2001，131，7： | 1 |
| 4 | Gas phase decarboxylation of carboxylic acids显示文摘 | MAIER W F ROTH W THIES I RAGDE SCHLEYER P V | 1982 | Chern Ber1982，115，2： | 1 |
| 5 | Xenobiotic biotrasformation in unicellular green algae 显示文摘 | Thies F Backhaus T Bossmann B | 1996 | Plant Physiol1996，112，： | 1 |
| 6 | A Test of Stulz's Overinvestment Hypothesis 显示文摘 | Mark K and Clifford F Thies | 1995 | Financial Review 301995，，： | 1 |
| 7 | Investigation of the MS-Al2S3 system ( M = Ca, Sr, Ba ) and luminescence properties of europium-doped thioaluminates显示文摘 | Le Thi K T Garcia A Guillen F | 1992 | Material Science and Engineering B1992，14，4： | 1 |
| 8 | Effects of water stress on the biosynthesis and degradation of polyunsaturated lipid molecular species in leaves of Vigna un- guiculata 显示文摘 | Monteiro de Paula F Thi anh thu P Zuily-Fodil Y | 1993 | Plant Physiology and Biochemistry1993，31，5： | 1 |
| 9 | Factors Determining Inpatient Satisfaction with Care显示文摘 | Nguyen Thi P L Briancon S Empereur F | 2002 | Soc Sci Med2002，54，4： | 1 |
| 10 | MALDI - TOF mass spectrometry: Obtaining reliable mass spectra for insoluble carbonaceous pitches显示文摘 | EDWARDS W F JIN L THIES M C | 2003 | Carbon2003，41，： | 1 |
| 11 | Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans显示文摘 | Thies F Powell JR | 2001 | Nutr2001，131，7： | 1 |
| 12 | Fatty acids and lymphocyte fimctions显示文摘 | Calder PC Yaqoob P Thies F | 2002 | Br J Nutr2002，87，1： | 1 |
| 13 | Determination of bisphenol A BPA by gas chromatography mass spectrometry and 1 HNMR spectroscopy during curing of epoxy amine resins 显示文摘 | Perrin F X Nguyen Thi Minh Hanh Tran Thi My Linh | 2006 | Polymer Testing2006，25，7： | 1 |
| 14 | Octree rasterization:acceleratiag high- quality out-of-core GPU volume rendering显示文摘 | Liu B C lapwor thy G ] Dong F | 2013 | Visualization and uter Grhics IE Trsactions on2013，19，10： | 1 |
| 15 | Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, dis- ease-free, middle-aged adults : a randomized controlled tria 显示文摘 | Thies F Massm~ LF Rudd A | 2012 | Am J Clin Nutr2012，95，5： | 1 |
| 16 | Double-cropping cucumbers and squash after resistant bell pepper for root-knot nematode management显示文摘 | Thies J A Davis R F Mueller J D | 2004 | Plant Dis2004，88，： | 1 |
| 17 | Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults显示文摘 | Thies F Miles E A Nebe-von-Caron G | 2001 | Lipids2001，36，11： | 1 |
| 18 | Effect of whole linseed (Linum usitatissimum) in the diet of finishing pigs on growth performance and on the quality and fatty acid composition of various tissues 显示文摘 | MATTHEWS K R HOMER D B THIES F | 2000 | British Journal of Nutrition2000，83，6： | 1 |
| 19 | Effect of whole linseed(linum usitatissimum)in the diet of finishing pigs on growth performance and on the quality and fatty acid composition of various tissues显示文摘 | Matthews K K Homer D B Thies F | 2000 | British Journal of Nutrition2000，83，： | 1 |
| 20 | Neuronal circuits of fear extinction显示文摘 | Herry C Ferraguti F Singewald N Letzkus J.J Ehrlich I & Lüthi A | | 0，，04： | 1 |
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